[1]王　雷,刘　华.鹿瓜多肽注射液联合椎体成形术治疗老年骨质疏松性胸腰椎压缩性骨折的疗效及对患者骨代谢的影响[J].新乡医学院学报,2016,33(10):878-880.[doi:10.7683/xxyxyxb.2016.10.011]
　WANG Lei,LIU Hua.Curative efficacy of cervus&cucumis polypeptide injection combined with vertebroplasty in elderly patients osteoporotic vertebral compression fracture of thoracolumbar spine&bone metabolism effect[J].Journal of Xinxiang Medical University,2016,33(10):878-880.[doi:10.7683/xxyxyxb.2016.10.011]
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鹿瓜多肽注射液联合椎体成形术治疗老年骨质疏松性胸腰椎压缩性骨折的疗效及对患者骨代谢的影响
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年10
页码:
878-880
栏目:
临床研究
出版日期:
2016-10-05

文章信息/Info

Title:
Curative efficacy of cervus&cucumis polypeptide injection combined with vertebroplasty in elderly patients osteoporotic vertebral compression fracture of thoracolumbar spine&bone metabolism effect
作者:
王　雷; 刘　华
（陕西省中医医院骨科，陕西　西安　710003）
Author(s):
WANG Lei; LIU Hua
（Department of Orthopedics,Traditional Chinese Medicine Hospital of Shaanxi Province,Xi′an 710003,Shaanxi Province,China）
关键词:
鹿瓜多肽注射液; 椎体成形术; 老年; 骨质疏松性胸腰椎压缩性骨折; 骨代谢
Keywords:
cervus and cucumis polypeptide injection; vertebroplasty; elderly; osteoporotic vertebral compression fracture of thoracolumbar spine; bone metabolism
分类号:
R683.2
DOI:
10.7683/xxyxyxb.2016.10.011
文献标志码:
A
摘要:
目的　探讨鹿瓜多肽注射液联合椎体成形术治疗老年骨质疏松性胸腰椎压缩性骨折的疗效及对骨代谢的影响。方法　选取2014年1月至2015年2月于陕西省中医医院接受治疗的128例老年骨质疏松性胸腰椎压缩性骨折患者作为研究对象，分为对照组62例和观察组66例。对照组患者行椎体成形手术治疗，观察组患者在对照组基础上联合应用鹿瓜多肽注射液治疗。采用视觉模拟评分（VAS）评价疼痛程度。随访3个月，比较2组患者临床疗效、Cobb角、VAS评分及骨代谢指标水平。结果　2组患者均手术成功，随访3个月，无严重并发症，其中观察组患者治疗总有效率为93.9%，显著高于对照组的80.6%（P<0.05）。术后3个月，与对照组患者相比，观察组患者Cobb角减小，VAS评分降低，骨代谢指标骨碱性磷酸酶、空腹血骨钙素水平升高，人胶原交联羧基末端肽水平下降（P<0.05）。结论　鹿瓜多肽注射液联合椎体成形术治疗老年骨质疏松性胸腰椎压缩性骨折疗效可靠，能够有效恢复胸腰椎正常形态，缓解疼痛，改善骨代谢，且无严重并发症。
Abstract:
Objective　To investigate the curative efficacy of cervus and cucumis polypeptide injection combined with vertebroplasty in treatment of elderly patients with osteoporotic vertebral compression fracture of thoracolumbar spine and its effect on bone metabolism of patients.Methods　One hundred and twenty-eight elderly patients with osteoporotic vertebral compression fracture of thoracolumbar spine who received therapy in Traditional Chinese Medicine Hospital of Shaanxi Province from January 2014 to February 2015 were selected as research objects.The patients were divided into control group (n=62) and observation group (n=66).The patients in control group was treated with vertebroplasty;based on this,the patients in observation group was given cervus and cucumis polypeptide injection.The visual analogue score (VAS) was used to appraise degree of pain.After the three-month follow-up,the curative efficacy,Cobb angle,scores of VAS and indices of bone metabolism were compared between the two group.Results　All the patients underwent successful surgery with no severe complication during the three-month follow-up.The total effective rate of patients in observation group was 93.9%,which was significantly higher than that in the control group(80.6%) (P<0.05).Three months after the surgery,compared with the control group,the Cobb angle,scores of VAS and human cross-linked carboxy-terminal telopetide of collagen of patients decreased and the levels of bone alkaline phosphatase and fasting blood osteocalcin of patients increased in the observation group (P<0.05).Conclusion　Cervus and cucumis polypeptide injection combined with vertebroplasty for treatment of elderly patients with osteoporotic vertebral compression fracture of thoracolumbar spine is effective and with no severe complication.It can significantly recover thoracolumbar normal form,alleviate pain and improve bone metabolism.

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更新日期/Last Update: 2016-10-05