[1]朱春玲.低分子肝素钙联合双嘧达莫治疗下肢骨折患者术后下肢深静脉血栓的疗效[J].新乡医学院学报,2016,33(1):064-66.[doi:10.7683/xxyxyxb.2016.01.019]
　ZHU Chun-ling.Effect of low molecular heparin calcium combined with dipyridamole on deep vein thrombosis of lower limb in patients with fracture of lower limb after operation[J].Journal of Xinxiang Medical University,2016,33(1):064-66.[doi:10.7683/xxyxyxb.2016.01.019]
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低分子肝素钙联合双嘧达莫治疗下肢骨折患者术后下肢深静脉血栓的疗效
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年1
页码:
064-66
栏目:
临床研究
出版日期:
2016-01-05

文章信息/Info

Title:
Effect of low molecular heparin calcium combined with dipyridamole on deep vein thrombosis of lower limb in patients with fracture of lower limb after operation
作者:
朱春玲
（咸宁市中心医院药剂科，湖北　咸宁　437100）
Author(s):
ZHU Chun-ling
(Department of Pharmaceutics，the Central Hospital of Xianning City，Xianning 437100，Hubei Province，China)
关键词:
低分子肝素钙; 双嘧达莫; 下肢骨折; 深静脉血栓
Keywords:
low molecular weight heparin; dipyridamole; fracture of lower limb; deep vein thrombosis
分类号:
R619+.2
DOI:
10.7683/xxyxyxb.2016.01.019
文献标志码:
A
摘要:
目的　探讨低分子肝素钙联合双嘧达莫治疗下肢骨折患者术后下肢深静脉血栓（DVT）的临床效果。方法　84例下肢骨折术后DVT患者根据治疗方法分为观察组及对照组，每组42例，对照组患者给予双嘧达莫治疗，观察组患者给予低分子肝素钙联合双嘧达莫治疗，2组疗程均为7 d。对2组患者血浆D-二聚体（D-D）和纤维蛋白原（FIB）水平、全血黏度及不良反应发生率进行比较。结果　观察组和对照组患者治疗总有效率分别为95.24%（40/42）和76.19%（32/42），观察组患者治疗总有效率显著高于对照组（P<0.05）；观察组和对照组患者不良反应发生率分别为16.67％（7/42）和11.90％（5/42），2组患者不良反应发生率比较差异无统计学意义（P>0.05）。治疗前2组患者血浆D-D、FIB水平及全血黏度比较差异均无统计学意义（P>0.05）。2组患者治疗3、7 d时血浆D-D、FIB水平及全血黏度均显著低于治疗前（P<0.05）；2组患者治疗7 d时血浆D-D、FIB水平及全血黏度均显著低于治疗3 d时（P<0.05）。观察组患者治疗3、7 d时血浆D-D、FIB水平及全血黏度均显著低于对照组（P<0.05）。结论　低分子肝素钙联合双嘧达莫能有效降低下肢骨折术后DVT患者血浆D-D、FIB水平及全血黏度，提高DVT治疗效果，且安全可靠。
Abstract:
Objective　To investigate the effect of low molecular heparin calcium combined with dipyridamole on deep vein thrombosis(DVT) of lower limb in patients with fracture of lower limb after operation.Methods　A total of 84 patients with fracture and DVT of lower limb were divided into observation group and control group according to therapeutic method after operation，with 42 cases in each group.The patients in control group were treated with dipyridamole，the patients in observation group were treated with low molecular heparin calcium and dipyridamole.The patients in the two groups were treated for seven days.The levels of plasma D-dimer(D-D)，fibrinogen(FIB)，whole blood viscosity and the incidence of adverse reaction were compared between the two groups.Results　The total effective rate in observation group and control group was 95.24%(40/42) and 76.19%(32/42) respectively，the total effective rate in observation group was significantly higher than that in control group(P<0.05).The incidence of adverse reaction in observation group and control group was 16.67%(7/42) and 11.90%(5/42) respectively，there was no significant difference between the two groups(P>0.05).There was no significant difference in plasma D-D，FIB levels and whole blood viscosity between the two groups before treatment(P>0.05).The levels of plasma D-D，FIB and whole blood viscosity after treatment for 3 and 7 days were significantly lower than those before treatment in the two groups(P<0.05).The levels of plasma D-D，FIB and whole blood viscosity after treatment for 7 days were significantly lower than those after treatment for 3 days in the two groups(P<0.05).The levels of plasma D-D，FIB and whole blood viscosity in observation group were significantly lower than those in control group after treatment for 3 and 7 days(P<0.05).Conclusion　Low molecular heparin calcium combined with dipyridamole for treating DVT of lower limb can effectively decrease the levels of plasma D-D，FIB and whole blood viscosity and improve the treatment effect，which is safe and reliable.

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更新日期/Last Update: 2016-01-05