[1]王丽,赵朵朵.硝苯地平和低分子肝素钙联合治疗对早发型重度子痫前期患者氧化应激、血压及母婴结局的影响[J].新乡医学院学报,2023,40(3):249-252.[doi:10.7683/xxyxyxb.2023.03.010]
　WANG Li,ZHAO Duoduo.Effect of nifedipine combined with low molecular weight heparin calcium on oxidative stress,blood pressure and maternal and infant outcome in patients with early-onset severe preeclampsia[J].Journal of Xinxiang Medical University,2023,40(3):249-252.[doi:10.7683/xxyxyxb.2023.03.010]
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硝苯地平和低分子肝素钙联合治疗对早发型重度子痫前期患者氧化应激、血压及母婴结局的影响
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
40卷
期数:
2023年3期
页码:
249-252
栏目:
临床研究
出版日期:
2023-03-05

文章信息/Info

Title:
Effect of nifedipine combined with low molecular weight heparin calcium on oxidative stress,blood pressure and maternal and infant outcome in patients with early-onset severe preeclampsia
作者:
王丽; 赵朵朵
（三门峡市中心医院产科，河南　三门峡　472000）
Author(s):
WANG Li; ZHAO Duoduo
(Department of Obstetrics,Sanmenxia Central Hospital,Sanmenxia 472000,Henan Province,China)
关键词:
早发型重度子痫前期; 低分子肝素钙; 硝苯地平; 超氧化物歧化酶; 谷胱甘肽过氧化物酶; 血压; 母婴结局
Keywords:
early-onset severe preeclampsia; low molecular weight heparin calcium; nifedipine; superoxide dismutase; glutathione peroxidase; blood pressure; maternal and infant outcome
分类号:
R714.245
DOI:
10.7683/xxyxyxb.2023.03.010
文献标志码:
A
摘要:
目的探讨硝苯地平和低分子肝素钙联合治疗对早发型重度子痫前期（EOSP）患者氧化应激、血压及母婴结局的影响。
方法选择2020年1月至2022年1月三门峡市中心医院产科二病区收治的160例EOSP患者为研究对象，根据治疗方法将患者分为观察组和对照组，每组80例。2组患者均给予硫酸镁解痉、纠正低蛋白血症、持续低流量吸氧、加强营养等常规对症支持治疗。在常规治疗基础上，对照组患者给予硝苯地平治疗，观察组患者给予硝苯地平和低分子肝素钙联合治疗，2组患者均治疗1周。治疗后评估2组患者的临床疗效；分别于治疗前后采用黄嘌呤氧化酶法检测血清超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）活性，采用硫代巴比妥酸法检测血清丙二醛（MDA）、脂质过氧化物（LPO）水平，使用血压检测仪测定2组患者的收缩压（SBP）和舒张压（DBP）；治疗后对所有患者进行随访，记录2组患者不良妊娠结局的发生情况。
结果观察组和对照组患者治疗总有效率分别为 92.50%（74/80）、81.25%（65/80），观察组患者治疗总有效率显著高于对照组（χ2=4.440，P<0.05）。治疗前2组患者血清SOD、GSH-Px、MDA、LPO水平比较差异无统计学意义（P>0.05）；2组患者治疗后的血清SOD、GSH-Px水平显著高于治疗前，血清MDA、LPO水平显著低于治疗前（P<0.05）；治疗后，观察组患者血清SOD、GSH-Px水平显著高于对照组，血清MDA、LPO水平显著低于对照组（P<0.05）。治疗前2组患者的SBP、DBP比较差异无统计学意义（P>0.05），2组患者治疗后的SBP、DBP显著低于治疗前（P<0.05）；治疗后，观察组患者的SBP、DBP显著低于对照组（P<0.05）。观察组和对照组不良妊娠结局发生率分别为6.25%（5/80）、18.75%（15/80），观察组不良妊娠结局发生率显著低于对照组（χ2=5.714，P<"0.05）。
结论硝苯地平和低分子肝素钙联合治疗可以有效改善EOSP患者的氧化应激状态，控制血压，降低不良妊娠结局发生率。
Abstract:
ObjectiveTo investigate the effect of nifedipine combined with low molecular weight heparin calcium on oxidative stress,blood pressure and maternal and infant outcome in patients with early-onset severe preeclampsia (EOSP).MethodsA total of 160 EOSP patients admitted to the Second Obstetrical Ward of Sanmenxia Central Hospital from January 2020 to January 2022 were selected as the study subjects,and the patients were divided into observation group and control group according to the treatment methods,with 80 patients in each group.The patients in the both groups were treated with routine symptomatic support treatment suchas magnesium sulfate for spasmolysis,correcting hypoproteinemia,continuous low flow oxygen" inhalation,enhancing nutrition,and so on.On the basis of routine treatment,the patients in the control group were treated with nifedipine,while the patients in the observation group were treated with nifedipine and low molecular weight heparin calcium.The patients in the both groups were treated for one week.The clinical efficacy of patients in the two groups was evaluated after treatment.The activities of serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured by xanthine oxidase method,the levels of serum malondialdehyde (MDA) and lipid peroxide (LPO) were measuredby thiobarbituric acid method,and the systolic blood pressure (SBP) and diastolic blood pressure (DBP) of patients in the two groups were measured by sphygmomanometer before and after treatment.All patients were followed up after treatment to record the occurrence of adverse pregnancy outcomes.ResultsThe total effective rate of patients in the observation group and the control group was 92.50% (74/80) and 81.25% (65/80),respectively.The total effective rate of patients in the observation group was significantly higher than that in the control group(χ2=4.440,P<0.05).There was no significant difference in serum SOD,GSH-Px,MDA and LPO levels between the two groups before treatment (P>0.05).Compared with before treatment,the levels of serum SOD and GSH-Px of patients in the two groups were significantly increased after treatment,while the levels of serum MDA and LPO were significantly decreased (P<0.05).After treatment,the levels of serum SOD and GSH-Px of patients in the observation group were significantly higher than those in the control group,and the levels of serum MDA and LPO were significantly lower than those in the control group (P<0.05).There was no significant difference in SBP and DBP of patients between the two groups before treatment (P>0.05).The SBP and DBP of patients in the two groups after treatment were significantly lower than those before treatment (P<0.05).After treatment,the SBP and DBP of patients in the observation group were significantly lower than those in the control group (P<0.05).The incidence of adverse pregnancy outcomes of patients in the observation group and the control group was 6.25% (5/80) and 18.75% (15/80),respectively.The incidence of adverse pregnancy outcomes of patients in the observation group was significantly lower than that in the control group(χ2=5.714,P<0.05).ConclusionThe combined treatment of nifedipine and low molecular weight heparin calcium can effectively improve the oxidative stress state,control blood pressure,and reduce the incidence of adverse pregnancy outcomes in patients with EOSP.

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更新日期/Last Update: 2023-03-05