[1]陈　婷,周永学,王　渊,等.肠道菌群调节治疗阿尔茨海默病研究进展[J].新乡医学院学报,2022,39(4):387-391.[doi:10.7683/xxyxyxb.2022.04.018]
　CHEN Ting,ZHOU Yongxue,WANG Yuan,et al.Research progress of regulating intestinal flora in the treatment of Alzheimer′s disease[J].Journal of Xinxiang Medical University,2022,39(4):387-391.[doi:10.7683/xxyxyxb.2022.04.018]
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肠道菌群调节治疗阿尔茨海默病研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
39
期数:
2022年4
页码:
387-391
栏目:
综述
出版日期:
2022-04-05

文章信息/Info

Title:
Research progress of regulating intestinal flora in the treatment of Alzheimer′s disease
作者:
陈　婷1; 2; 周永学1; 2; 王　渊3; 闫曙光1; 2; 李京涛4; 魏海梁5
(1.陕西中医药大学基础医学院胃肠病教研室，陕西　咸阳　712046；2.陕西省胃肠病证方药重点研究室，陕西　咸阳　712046；3.陕西中医药大学针灸学院，陕西　咸阳　712046；4.陕西中医药大学附属医院肝病科，陕西　咸阳　712046；5.陕西中医药大学附属医院普外科,陕西　咸阳　712046）
Author(s):
CHEN Ting1; 2; ZHOU Yongxue1; 2; WANG Yuan3; YAN Shuguang1; 2; LI Jingtao4; WEI Hailiang5
(1.Department of Gastroenterology,Basic Medical College,Shaanxi University of Traditional Chinese Medicine;2.Key Laboratory of Prescriptions and Drugs for Gastrointestinal Diseases in Shaanxi Province;3.College of Acupuncture and Moxibustion,Shaanxi University of Traditional Chinese Medicine;4.Department of Hepatology,the Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine;5.Department of General Surgery,the Affiliated Hospital of Shaanxi University of TCM)
关键词:
阿尔茨海默病; 肠道菌群; 潜在疗法
Keywords:
Alzheimer′s disease; intestinal flora; potential therapy
分类号:
R742
DOI:
10.7683/xxyxyxb.2022.04.018
文献标志码:
A
摘要:
阿尔茨海默病(AD)是一种常见的以短期和长期记忆丧失、决策能力受损、健忘和认知障碍为特征的与年龄高度相关且呈进行性改变的神经退行性疾病。AD的发病和治疗机制尚未完全明确。近年研究发现，肠道菌群与宿主的行为和认知功能密切相关，而肠道菌群多样性失衡可诱发神经系统疾病；因此，调节肠道菌群可能成为干预AD发病与进展的新靶点。本文从肠道菌群的定义及其作用、肠道菌群与AD的关系、通过不同治疗方法调节肠道菌群干预AD的研究进展等方面进行综述。
Abstract:
Alzheimer′s disease(AD) is one of the most common neurodegenerative diseases with highly age-related and progressive changes,it is characterized by short-term and long-term memory loss,impaired decision-making ability,amnesia and cognitive impairment.The pathogenesis and treatment mechanism of AD have not been fully clarified.Recent research found that the intestinal flora is closely related to the behavior and cognitive function of the host,and the imbalance of intestinal flora diversity can induce nervous system diseases.Therefore,regulation of intestinal flora may be a new target for interventing the pathogenesis and progression of AD.This paper reviews the definition and function of intestinal flora,the relationship between the intestinal flora and AD,intervention of AD by regulating intestinal flora through different treatment methods.

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更新日期/Last Update: 2022-04-05