[1]唐满妹,严芳艺,蔡清风,等.2017-2020年赣州市手足口病流行特征分析[J].新乡医学院学报,2024,(2):158-162.[doi:10.7683/xxyxyxb.2024.02.010]
　TANG Manmei,YAN Fangyi,CAI Qingfeng,et al.Epidemiological characteristics of hand-foot-mouth disease in Ganzhou city from 2017 to 2020[J].Journal of Xinxiang Medical University,2024,(2):158-162.[doi:10.7683/xxyxyxb.2024.02.010]
点击复制

2017-2020年赣州市手足口病流行特征分析
分享到：

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
期数:
2024年2
页码:
158-162
栏目:
临床研究
出版日期:
2024-02-05

文章信息/Info

Title:
Epidemiological characteristics of hand-foot-mouth disease in Ganzhou city from 2017 to 2020
作者:
唐满妹; 严芳艺; 蔡清风; 薛花; 雷琼; 胡晓军
(赣州市疾病预防控制中心检验科，江西　赣州　341000)
Author(s):
TANG Manmei; YAN Fangyi; CAI Qingfeng; XUE Hua; LEI Qiong; HU Xiaojun
(Department of Laboratory,Ganzhou Center for Disease Control and Prevention,Ganzhou 341000,Jiangxi Province,China)
关键词:
手足口病; 流行特征; 病原学
Keywords:
hand-foot-mouth disease; epidemiological characteristics; etiology
分类号:
R725.1
DOI:
10.7683/xxyxyxb.2024.02.010
文献标志码:
A
摘要:
目的　分析赣州市手足口病（HFMD）流行病学特征。
方法　采用描述性方法对2017-2020年中国疾病预防控制信息系统子系统“传染病监测系统”报告的赣州市HFMD流行病学资料进行分析，采用实时荧光聚合酶链反应对患者咽拭子、肛拭子或疱疹液进行肠道病毒（EV）核酸检测及分型检测，比较2020年与2017-2019年手足口病流行特征。
结果　2020年赣州市HFMD发病率显著低于2017-2019年HFMD年均发病率（χ2=50.587，P<0.05）。2020年，除会昌县外，赣州市其他各县区HFMD发病率较2017-2019年HFMD年均发病率显著下降（P<0.05）。2017-2019年HFMD发病率呈明显季节性，夏秋两季高发，2017和2018年分别在6月和9月形成 2 个发病高峰，2019年在6月出现1个夏季高峰。2020年流行趋势不同，夏秋呈极低流行态势，高峰值后移至冬季。2020年男性、女性和各年龄阶段的HFMD发病率较2017-2019年HFMD年均发病率显著下降（P<0.05）；发病年龄均主要分布在1~5岁，尤其以1~3岁儿童为主，各年龄HFMD发病率比较差异有统计学意义（P<0.05）。2020年赣州市HFMD肠道病毒阳性率显著低于2017-2019年（χ2=47.273，P<0.05）。2020年1月及3至9月HFMD肠道病毒阳性率显著低于2017-2019年同时期，11、12月份HFMD肠道病毒阳性率显著高于2017-2019年同时期（P<0.05）。2017-2019年病毒株CA16呈逐年上升趋势，在2019年时CA16成为优势毒株。2018-2020年感染CA6毒株的病例比率呈上升趋势，CA6成为2020年优势毒株。
结论　赣州市手足口发病具有明显人群特征和季节性，病原谱不断变化。
Abstract:
Objective　To analyze the epidemiological characteristics of hand-foot-mouth disease (HFMD) in Ganzhou.
Methods　The epidemiological data of HFMD reported by the Infectious Disease Surveillance System,a sub-system of China Disease Prevention and Control Information System,from 2017 to 2020 were analyzed by descriptive methods.Enterovirus (EV) nucleic acid and typing detections via throat swabs,anal swabs or herpes fluid of patients was detected by real-time fluorescent polymerase chain reaction.The change in HFMD epidemic characteristics was compared between 2020 and 2017-2019.
Results　The incidence of HFMD in Ganzhou in 2020 was significantly lower than that from 2017 to 2019 (χ2=50.587,P<0.05).In 2020,the incidence of HFMD in counties and districts of Ganzhou (except Huichang County) significantly decreased compared with that in 2017-2019 (P<0.05).From 2017 to 2019,the incidence of HFMD was obviously seasonal,with a high incidence in summer and autumn,and two significant incidence peaks were formed in June and September in 2017 and 2018,respectively.In 2019,there was a summer peak in June.The epidemic trend in 2020 was different,with a very low epidemic trend in summer and autumn,and a peak in winter.The incidence of HFMD in men,women and all ages in 2020 significantly decreased compared with that in 2017-2019 (P<0.05),and the age of onset was mainly distributed in 1-5 years,especially in children aged 1 to 3 years.There was a significant difference in the incidence of HFMD among different ages (P<0.05).The positive rate of EV in Ganzhou in 2020 was lower than that from 2017 to 2019 (χ2=47.273,P<0.05).The positive rate of EV in January,March to September in 2020 was significantly lower,and the positive rate of EV in November,December 2020 was significantly higher than that in the same period in 2017 to 2019 (P<0.05).Strain CA16 showed an increasing trend year by year from 2017 to 2019,and became the dominant strain in 2019.The proportion of patients infected with CA6 strain was on the fise from 2018 to 2020,and CA6 became the dominant strain in 2020.
Conclusion　The HFMD in Ganzhou has obvious population characteristics and seasonality,and the pathogen spectrum is constantly changing.

参考文献/References:

［1］　LI X W,NI X，QIAN S Y,et al.Chinese guidelines for the diagnosis and treatment of hand,foot and mouth disease (2018 edition)［J］.World J Pediatr,2018,14(5)：437-447.
［2］　李建华，廖勇，杨健平.2008—2010年赣州市手足口病疫情分析［J］.预防医学论坛,2011,17(7):640-642．
LI J H,LIAO Y,YANG J P.Analysis of hand-foot-mouth disease outbreaks in Ganzhou,2008-2010［J］.Prev Med Trib,2011,17(7):640-642.
［3］　杨健平，廖勇，李如，等.“金字塔模式”在手足口病防治中的应用［J］.现代预防医学,2012,39(24):6477-6481.
YANG J P,LIAO Y,LI R,et al.Application of “Pyramid Model” in hand-foot-mouth disease［J］.Mod Prev Med,2012,39(24):6477-6481.
［4］　2021年赣州统计年鉴［EB/OL］.(2022-01-24)［2022-10-20］.https://www.ganzhou.gov.cn/zfxxgk/c116025/202201/326ee082adfb4289b57cc56fd2eca403.shtml.
Statistical yearbook of Ganzhou in 2021［EB/OL］.(2022-01-24)［2022-10-20］.https://www.ganzhou.gov.cn/zfxxgk/c116025/202201/326ee082adfb4289b57cc56fd2eca403.shtml
［5］　WANG J,DING S,XIE W,et al.Epidemiological and etiological characteristics of mild hand-foot -mouth disease in children under 7 years old,Nanjing,China,2010-2019［J］.Arch Public Health,2022,80(1):220.
［6］　WANG J,ZHOU J,XIE G,et al.The epidemiological and clinical characteristics of hand-foot-mouth disease in hangzhou,China,2016 to 2018［J］.Clin Pediatr (Phila),2020,59(7):656-662.
［7］　JIANG L,JIANG H,TIAN X,et al.Epidemiological characteristics of hand-foot-mouth disease in Yunnan province,China,2008-2019［J］.BMC Infect Dis,2021,21(1):751.
［8］　GENG M J,ZHANG H Y,YU L J,et al.Changes in notifiable infectious disease incidence in China during the COVID-19 pandemic［J］.Nat Commun,2021,12(1):6923.
［9］　ULLRICH A,SCHRANZ M,REXROTH U,et al.Impact of the COVID-19 pandemic and associated non-pharmaceutical interventions on other notifiable infectious diseases in Germany:an analysis of national surveillance data during week 1-2016-week 32-2020［J］.Lancet Reg Health Eur,2021,19(6):100103.
［10］　LI H,LING F,ZHANG S,et al.Comparison of 19 major infectious diseases during COVID-19 epidemic and previous years in Zhejiang,implications for prevention measures［J］.BMC Infect Dis,2022,22(1):296.
［11］　韩鹏,柳杉杉,乔晶晶,等.儿童呼吸道病毒感染的非药物干预及其影响［J］.中华实用儿科临床杂志,2022,37(6)：466-470.
HAN P，LIU S S,QIAO J J，et al.Non-pharmaceutical interventions for respiratory virus infection in children and its effect［J］.Chin J Appl Clin Pediatr,2022,37(6):466-470.
［12］　ZHUANG Z C,KOU Z Q,BAI Y J,et al.Epidemiological research on hand-foot-mouth disease in mainland China［J］.Viruses,2015,7(12):6400-6411.
［13］　方续兰,汪丙松，李振，等．2020-2021年芜湖市某三甲医院手足口病流行病学特征及病原学检测结果分析［J］.中华全科医学,2022,20(6):993-995,999.
FANG X L,WANG B S,LI Z,et al.Analysis of epidemiological characteristics and etiological detection results of hand-foot-mouth disease in a top three hospital in Wuhu city from 2020 to 2021［J］.Chin J Gen Pract,2022,20(6):993-995,999.
［14］　DAI C X,WANG Z,WANG W M,et al.Epidemics and underlying factors of multiple-peak pattern on hand,foot and mouth disease in Wenzhou,China［J］.Math Biosci Eng,2019,16(4):2168-2188.
［15］　黄建英,李静静,刘妙玲,等.新型冠状病毒肺炎疫情对儿童传染病报告影响［J］.中国公共卫生,2021,10(37):1527-1530.
HUANG J Y,LI J J,LIU M L,et al.The impact of the novel coronavirus pneumonia epidemic on the reporting of infectious diseases in children［J］.Chin Public Health,2021,10(37):1527-1530.
［16］　丁克琴,易波,陈奕,等.宁波市手足口病患者密切接触人群肠道病毒检出情况及影响因素分析［J］.中国公共卫生,2020,36(1):92-95.
DING K Q,YI B,CHEN Y,et al.Analysis of enterovirus detection and influencing factors among close contacts of hand-foot-mouth disease patients in Ningbo［J］.Chin Public Health,2020,36 (1):92-95.
［17］　LIANG Z L，MAO Q Y，WANG Y P，et al.Progress on the research and development of inactivated EV71 whole-virus vaccines［J］.Hum Vaccin Immunother,2013,9(8):1701-1705．
［18］　ZHU F C，MENG F Y，LI J X，et al． Efficacy，safety，and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China:a multicenter,randomized,double-blind,placebo controlled,phase 3 trial［J］.Lancet,2013,381(9882):2024-2032.
［19］　LI R,LIU L,MO Z,et al.An inactivated enterovirus 71 vaccine in healthy children［J］.N Engl J Med,2014,370(9):829-837．
［20］　SUN Y S,LI Y J,XIA Y,et al.Coxsackievirus A16 induced neurological disorders in young gerbils which could serve as a new animal model for vaccine evaluation［J］.Sci Rep,2020,6:34299.
［21］　CHEN C,XIA Y,ZHU S R,et al.Muscle destruction caused by coxsackievirus A10 in gerbils:construction of a novel animal model for antiviral evaluation［J］.Virus Res,2020,286(1):198067.
［22］　QIAN S,WEI Z,JIN W,et al.Efficacy of a coxsackievirus A6 vaccine candidate in an actively immunized mouse model［J］.Emerg Microb Infect,2021,10(1):763-773．

相似文献/References:

[1]黄　可.手足口病并发脑炎患儿Ｔ淋巴细胞亚群的变化[J].新乡医学院学报,2015,32(08):766.
[2]陈　芳,宋春兰,陈　梅,等.肠道病毒71型和柯萨奇病毒A组16型感染手足口病患儿血清基质金属蛋白酶-9、白细胞介素-1β、白细胞介素-10水平变化及临床意义[J].新乡医学院学报,2021,38(8):757.[doi:10.7683/xxyxyxb.2021.08.012]
　CHEN Fang,SONG Chunlan,CHEN Mei,et al.Changes of serum matrix metalloproteinase-9,interleukin-1β and interleukin-10 levels of children with hand-foot and mouth disease infected with enterovirus 71 and coxsackie virus A 16 and clinical significance[J].Journal of Xinxiang Medical University,2021,38(2):757.[doi:10.7683/xxyxyxb.2021.08.012]
[3]秦新华,王　芳,赵保玲.重组人干扰素对手足口病大鼠的治疗作用及对Toll样受体/髓样分化因子相关信号分子的影响[J].新乡医学院学报,2020,37(1):015.[doi:10.7683/xxyxyxb.2020.01.005]
　QIN Xinhua,WANG Fang,ZHAO Baoling.Therapeutic effect of recombinant human interferon on rats with hand-foot-mouth disease and its influence on toll-like receptor/myeloid differential protein-88 related signaling molecules[J].Journal of Xinxiang Medical University,2020,37(2):015.[doi:10.7683/xxyxyxb.2020.01.005]
[4]吴书惠,于莉莉.柯萨奇病毒A组6型研究进展[J].新乡医学院学报,2020,37(8):787.[doi:10.7683/xxyxyxb.2020.08.020]

更新日期/Last Update: 2024-02-05