[1]王一茜,张少康,赵德安.中性粒细胞胞外陷阱在风湿免疫性疾病中的作用研究进展[J].新乡医学院学报,2023,40(7):696-700.[doi:10.7683/xxyxyxb.2023.07.018]
　WANG Yiqian,ZHANG Shaokang,ZHAO Dean.Research progress on the role of neutrophil extracellular traps in rheumatic immune disease[J].Journal of Xinxiang Medical University,2023,40(7):696-700.[doi:10.7683/xxyxyxb.2023.07.018]
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中性粒细胞胞外陷阱在风湿免疫性疾病中的作用研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
40卷
期数:
2023年7
页码:
696-700
栏目:
综述
出版日期:
2023-07-05

文章信息/Info

Title:
Research progress on the role of neutrophil extracellular traps in rheumatic immune disease
作者:
王一茜1; 张少康2; 赵德安1
（1.新乡医学院第一附属医院儿科，河南　卫辉　453100；2.郑州市第一人民医院神经内科，河南　郑州　450004）
Author(s):
WANG Yiqian1; ZHANG Shaokang2; ZHAO Dean1
（1.Department of Pediatrics,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,Henan Province,China;2.Department of Neurology,the First People′s Hospital of Zhengzhou,Zhengzhou 450004,Henan Province,China）
关键词:
中性粒细胞胞外陷阱; 中性粒细胞; 风湿免疫性疾病; 血管炎
Keywords:
neutrophil extracellular traps; neutrophil; rheumatic immune disease; vasculitis
分类号:
R593.2
DOI:
10.7683/xxyxyxb.2023.07.018
文献标志码:
A
摘要:
中性粒细胞胞外陷阱（NETs）作为中性粒细胞所释放出的一种网状组织，在炎症反应中充当先天防御宿主的角色，能够诱导捕获并杀灭微生物；NETs可参与多种疾病的发生，具有双向免疫调节作用。NETs生成过剩或机体清除减少可导致系统性红斑狼疮、类风湿性关节炎、抗中性粒细胞胞质抗体相关性血管炎及川崎病等免疫性疾病。NETs可能成为风湿免疫性疾病诊断和治疗中新的靶点。
Abstract:
Neutrophil extracellular traps（NETs） as a kind of network tissue released by neutrophil granulocytes,play a role of innate host defense in inflammatory response,and which can induce the capture and killing of microorganisms.NETs can participate in the occurrence of a variety of diseases and has bidirectional immunomodulatory effect.Excessive generation or reduced clearance of NETs in the body can lead to immune diseases such as systemic lupus erythematosus,rheumatoid arthritis,anti-neutrophil cytoplasmic antibody associated vasculitis,and Kawasaki disease.NETs may become a new target in the diagnosis and treatment of rheumatic immune diseases.

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更新日期/Last Update: 2023-07-05