[1]周琼琼,薛秀珍.纤维蛋白原样蛋白2和肿瘤坏死因子-α在子痫前期发生发展中的作用研究进展[J].新乡医学院学报,2023,40(4):392-396.[doi:10.7683/xxyxyxb.2023.04.018]
　ZHOU Qiongqiong,XUE Xiuzhen.Research progress of the role of fibrinogen-like protein 2 and tumor necrosis factor-α in the occurrence and development of preeclampsia[J].Journal of Xinxiang Medical University,2023,40(4):392-396.[doi:10.7683/xxyxyxb.2023.04.018]
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纤维蛋白原样蛋白2和肿瘤坏死因子-α在子痫前期发生发展中的作用研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
40卷
期数:
2023年4
页码:
392-396
栏目:
综述
出版日期:
2023-04-05

文章信息/Info

Title:
Research progress of the role of fibrinogen-like protein 2 and tumor necrosis factor-α in the occurrence and development of preeclampsia
作者:
周琼琼1; 薛秀珍2
(1.河南科技大学临床医学院,河南　洛阳　471000;2.河南科技大学第一附属医院妇产科，河南　洛阳　471000)
Author(s):
ZHOU Qiongqiong1; XUE Xiuzhen2
(1.College of Clinical Medicine,Henan University of Science and Technology,Luoyang 471000,Henan Province，China;2.Department of Obstetrics and Gynecology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan Province,China)
关键词:
子痫前期; 纤维蛋白原样蛋白2; 肿瘤坏死因子-α
Keywords:
preeclampsia; fibrinogen-like protein 2; tumor necrosis factor-α
分类号:
R651
DOI:
10.7683/xxyxyxb.2023.04.018
文献标志码:
A
摘要:
子痫前期是一种妊娠期特有疾病，其病因和发病机制尚未明确。近年来随着研究的深入发现，免疫炎症在子痫前期中发挥重要作用。学者们逐渐认识到纤维蛋白原样蛋白2(FGL2)和肿瘤坏死因子-α（TNF-α）参与了免疫炎症过度激活导致的子痫前期。FGL2在子痫前期胎盘组织中发挥抗炎作用，通过抑制自身免疫及免疫排斥，保持免疫耐受。TNF-α通过促进滋养细胞凋亡、炎症反应激活及内皮细胞的损伤等机制，促进子痫前期的发生。本文就FGL2和TNF-α在子痫前期发生发展中的作用进行综述，为探讨其在子痫前期筛查和诊断中作为生物标志物的潜在用途提供新思路。
Abstract:
Preeclampsia is a special disease during pregnancy,and its etiology and pathogenesis are not yet clear.In recent years,with the deepening of research,immune inflammation plays an important role in preeclampsia.Scholars have gradually realized that fibrinogen-like protein 2 (FGL2) and tumor necrosis factor-α （TNF-α）involved in preeclampsia caused by excessive activation of immune inflammation.FGL2 plays an anti-inflammatory role in the placenta of preeclampsia and maintains immune tolerance.TNF-α can promote the occurrence of preeclampsia by promoting trophoblast apoptosis,inflammatory reaction activation and endothelial cell damage.This paper reviews the roles of FGL2 and TNF-α in the occurrence and development of preeclampsia,and provide new ideas for exploring their potential use as biomarkers in the screening and diagnosis of preeclampsia.

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更新日期/Last Update: 2023-04-05