[1]樊松强.前列舒通胶囊与非那雄胺片联合经尿道前列腺等离子双极电切术治疗良性前列腺增生症疗效观察[J].新乡医学院学报,2023,40(4):353-356.[doi:10.7683/xxyxyxb.2023.04.010]
　FAN Songqiang.Effect of Qianlie Shutong capsule and finasteride tablets combined with transurethral bipolar plasma kinetic prostatectomy in the treatment of benign prostatic hyperplasia[J].Journal of Xinxiang Medical University,2023,40(4):353-356.[doi:10.7683/xxyxyxb.2023.04.010]
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前列舒通胶囊与非那雄胺片联合经尿道前列腺等离子双极电切术治疗良性前列腺增生症疗效观察
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
40卷
期数:
2023年4
页码:
353-356
栏目:
临床研究
出版日期:
2023-04-05

文章信息/Info

Title:
Effect of Qianlie Shutong capsule and finasteride tablets combined with transurethral bipolar plasma kinetic prostatectomy in the treatment of benign prostatic hyperplasia
作者:
樊松强
（漯河市第二人民医院泌尿外科，河南　漯河　462000）
Author(s):
FAN Songqiang
(Department of Urology Surgery,Luohe Second People′s Hospital,Luohe 462000,Henan Province,China)
关键词:
良性前列腺增生症; 前列舒通胶囊; 非那雄胺; 经尿道前列腺等离子双极电切术
Keywords:
benign prostatic hyperplasia; Qianlie Shutong capsule; finasteride; transurethral bipolar plasma kinetic prostatectomy
分类号:
R697+.33
DOI:
10.7683/xxyxyxb.2023.04.010
文献标志码:
A
摘要:
目的探讨前列舒通胶囊、非那雄胺片联合经尿道前列腺等离子双极电切术（TUPKP）治疗良性前列腺增生症（BPH）的临床效果。方法选择2019年1月至2022年6月漯河市第二人民医院收治的60例BPH患者为研究对象，根据治疗方法将患者分为观察组和对照组，每组30例。所有患者均行TUPKP治疗。观察组患者术前2周给予前列舒通胶囊和非那雄胺片，术后第2天继续口服前列舒通胶囊4周，非那雄胺片2周；对照组患者术前2周口服非那雄胺片，术后第2天继续口服非那雄胺片2周。对2组患者的手术时间、切除前列腺组织质量、术中出血量、术中冲洗量、术后冲洗量、术后冲洗时间、最大尿流率（Qmax）、膀胱残余尿（PVR）、国际前列腺症状评分（IPSS）、生活质量（QOL）评分进行比较。结果2组患者的手术时间、切除前列腺组织质量比较差异无统计学意义（P>0.05）；观察组患者的术中出血量、术中冲洗量、术后冲洗量显著少于对照组，术后冲洗时间显著短于对照组（P<0.05）。治疗前2组患者Qmax、PVR比较差异无统计学意义（P>0.05）；2组患者治疗后Qmax显著升高，PVR显著减少（P<0.05）；治疗后，观察组患者Qmax显著高于对照组，PVR显著少于对照组（P<0.05）。治疗前2组患者IPSS、QOL评分比较差异无统计学意义（P>0.05）；2组患者治疗后IPSS、QOL评分显著低于治疗前（P<0.05）；治疗后，观察组患者IPSS评分、QOL评分显著低于对照组（P<0.05）。结论BPH患者TUPKP手术前后联合应用前列舒通胶囊和非那雄胺可显著减少术中出血量、冲洗量和术后PVR，提高术后Qmax，改善患者生活质量。
Abstract:
ObjectiveTo investigate the clinical effect of Qianlie Shutong capsule and finasteride tablets combined with transurethral bipolar plasma kinetic prostatectomy (TUPKP) in the treatment of benign prostatic hyperplasia (BPH).MethodsSixty patients with BPH admitted to Luohe Second People′s Hospital from January 2019 to June 2022 were selected as the study subjects,and the patients were divided into observation group and control group according to the treatment methods,with 30 patients in each group.All patients were treated with TUPKP.The patients in the observation group were treated with Qianlie Shutong capsule and finasteride tablets for two weeks before operation,and continued to take Qianlie Shutong capsule for four weeks and finasteride tablets for two weeks from the second day after operation.The patients in the control group were treated with finasteride tablets for two weeks before operation and continued to take finasteride tablets for two weeks from the second day after operation.The operation time,the mass of excised prostate tissues,intraoperative bleeding,intraoperative flushing fluid volume,postoperative flushing fluid volume,postoperative flushing time,maximum urine flow rate (Qmax),postvoid residual urine (PVR),international prostate symptom score (IPSS) and quality of life (QOL) score of patients were compared between the two groups.ResultsThere was no significant difference in the operation time and the mass of excised prostate tissues of patients between the two groups (P>0.05).The intraoperative bleeding volume,intraoperative and postope-rative flushing fluid volume of patients in the observation group were significantly less than those in the control group,and the postoperative flushing time of patients in the observation group was significantly shorter than that in the control group (P<0.05).There was no significant difference in the Qmax and PVR of patients between the two groups before treatment (P>0.05).The Qmax increased and the PVR decreased significantly after treatment in the two groups (P<0.05).After treatment,the Qmax of patients in the observation group was significantly higher than that in the control group,the PVR was significantly lower than that in the control group (P<0.05).There was no significant difference in the IPSS and QOL score of patients between the two groups before treatment (P>0.05).The IPSS and QOL score of patients in the two groups after treatment were significantly lower than those before treatment (P<0.05).The IPSS and QOL score of patients in the observation group were significantly lower than those in the control group after treatment (P<0.05).ConclusionThe combination of Qianlie Shutong capsule and finasteride before and after TUPKP can significantly reduce intraoperative bleeding,flushing fluid volume and postoperative PVR,increase postoperative Qmax,and improve QOL of patients with BPH.

参考文献/References:

［1］　绍文光，王建忠，姜雷.前列舒通联合非那雄胺对良性前列腺增生术后患者血管内皮生长因子、热休克蛋白、前列腺特异性抗原及性激素的影响分析［J］.中国性科学，2022，31（5）：37-41.
SHAO W G,WANG J Z,JIANG L.Effect of Qianlieshutong combined with finasteride on VEGF，HSP，PSA and sex hormone in patients with benign prostatic hyperplasia after operation［J］.Chin J Human Sexual,2022,31(5):37-41.
［2］　郑萍.前列舒通胶囊联合TURP治疗良性前列腺增生的效果观察［J］.天津药学，2022，34（6）：47-50.
ZHENG P.Effect of Qianlieshutong capsule combined with TURP on benign prostatic hyperplasia［J］.Tianjin Pharm,2022,34(6):47-50.
［3］　刘夏光.非那雄胺联合经尿道前列腺等离子电切术治疗前列腺增生患者的临床效果［J］.智慧健康，2022，8（32）：88-91.
LIU X G.Clinical effect of finasteride combined with transurethral plasma resection of prostate in the treatment of patients with benign prostatic hyperplasia［J］.Smart Healthc,2022,8(32):88-91.
［4］　ANGRIMANI D S R,SILCERSTRINI G R,BRITO M M,et al.Effects of benign prostatic hyperplasia and finasteride therapy on prostatic blood flow in dogs［J］.Theriogenology,2018,114:103-108.
［5］　KAPLAN S A.Development of a doxazosin and finasteride transdermal system for combination therapy of benign prostatic hyperplasia［J］.J Urol,2015,193(2):731-732.
［6］　沈建良，马小英，朱彩英，等.术前服用非那雄胺对前列腺电切术后出血的影响研究［J］.国际泌尿系统杂志，2020，40（6）：1048-1051.
SHEN J L,MA X Y,ZHU C Y,et al.Effect of finasteride on bleeding after prostatectomy［J］.Int J Urol Nephrol,2020,40(6):1048-1051.
［7］　LIMA C B,ANGRIMANI D S R,FLORES R B,et al.Endocrine,prostatic vascular,and proapoptotic changes in drogs with benign prostatic hyperplasia treated medically or surgically［J］.Domest Anim Endocrinol,2021,75:106601.
［8］　孙佰玲，何婷，倪建鑫.不同剂量非那雄胺对经尿道前列腺汽化电切术患者尿道功能与性功能的影响［J］.实用医院临床杂志，2021,18（6）：29-32.
SUN B L,HE T，NI J X.The effects of different doses of finasteride on urethral function and sexual function of patients undergoing transurethral vaporization of prostate［J］.PJCM,2021,18(6):29-32.
［9］　张志杰.前列疏通胶囊联合盐酸坦索罗辛胶囊治疗经尿道前列腺切除术后患者的效果及对炎性因子水平的影响［J］.中国中医结合外科杂志，2021，27（3）：447-450.
ZHANG Z J.Effect of Qianlie Shutong capsule combined with tamsulosin hydrochloride capsule on the level of inflammatory factors in patients after TURP［J］.Chin J Surg Integr Tradit Western Med,2021,7(3):447-450.
［10］　屈涛，张华，陈建设.前列疏通胶囊联合前列康灌肠对湿热瘀阻型Ш型慢性前列腺炎患者的临床疗效［J］.中成药，2020,42（5）：1199-1203.
QU T,ZHANG H,CHEN J S.Clinical effects of Qianlie Shutong capsules combined with Qianliekang decoction enema on patients with type Ⅲ chronic prostatitis due to damp-heat and blood-stasis accumulation［J］.Chin Tradit Pat Med,2020,42(5):1199-1203.
［11］　任钧国，王建业，李军梅，等.前列舒通胶囊对前列腺增生抑制作用的机制探讨［J］世界中医，2013,8（12）：70-72.
REN J G,WANG J Y,LI J M,et al.Study on the inhibitory mechanism of Qianlie Shutongcapsule on prostatic hyperplasia［J］.World Chin Med,2013,8(12):70-72.
［12］　操作亮，章传华，黄遂斌，等.前列疏通联合盐酸罗辛治疗慢性前列腺炎疗效评价及血清PSA、NGF、TGF-β的影响［J］.中华中医药学刊，2019，37（8）：1981-1985.
CAO Z L,ZHANG C H,HUANG S B,et al.Study on effect alprostol combined with tamsulosin hydrochloride in treatment chronic prostatitis and its effect on PSA,NGF and TGF-β in serum［J］.Chin Arch Tradit Chin Med,2019,37(8):1981-1985.
［13］　刘倩，红华，杨敬春，等.前列腺良恶性病变超声造影参数与VEGF、TGF-β1相关性的初步研究［J］.中国医疗设备，2019，34（4）：95-99.
LIU Q,HONG H,YANG J C,et al.Preliminary study on the relationship between the parameters of contrast-enhanced ultrasound and VEGF & TGF-β1 in benign and malignant lesions of prostate［J］.Chin Med Device,2019,34(4):95-99.
［14］　伍星海.探究前列腺疏通胶囊联合非那雄胺治疗良性前列腺增生症的临床疗效［J］.中国冶金工业医学杂志，2019，36（2）：156-157.
WU X H.Clinical efficacy of prostate dredging capsule combined with finasteride in the treatment of benign prostatic hyperplasia［J］.Chin Med J Metall Indus,2019,36(2):156-157.
［15］　周树明，郭青良，秦奋.前列舒通胶囊联合盐酸坦索罗辛缓释胶囊治疗前列腺增生术后临床研究［J］.新中医，2023，55（2）：95-99.
ZHOU S M,GUO Q L,QIN F.Clinical study on Qianlie Shutong capsules combined with tamsulosin hydrochloride sustained-release capsules for patients after surgery for prostatic hyperplasia［J］.New Chin Med,2023,55(2):95-99.

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更新日期/Last Update: 2023-04-05