[1]易慧芳,白伟利.丁苯酞治疗颈内动脉系统脑分水岭梗死疗效观察[J].新乡医学院学报,2022,39(10):968-971.[doi:10.7683/xxyxyxb.2022.10.013]
　YI Huifang,BAI Weili.Effect of butylphthalide on cerebral watershed infarction of internal carotid artery system[J].Journal of Xinxiang Medical University,2022,39(10):968-971.[doi:10.7683/xxyxyxb.2022.10.013]
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丁苯酞治疗颈内动脉系统脑分水岭梗死疗效观察
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
39
期数:
2022年10
页码:
968-971
栏目:
临床研究
出版日期:
2022-10-05

文章信息/Info

Title:
Effect of butylphthalide on cerebral watershed infarction of internal carotid artery system
作者:
易慧芳1; 白伟利2
（1.河南省军区郑州第三离职干部休养所，河南　郑州　450000；2.浏阳市集里医院神经内科，湖南　浏阳　410300 ）
Author(s):
YI Huifang1; BAI Weili2
(1.The Third Retirement Center for Retired Cadres of Zhengzhou,Henan Provincial Military Command,Zhengzhou 450000,Henan Province,China;2.Department of Neurology,Jili Hospital of Liuyang City,Liuyang 410300,Hunan Province,China）
关键词:
丁苯酞; 分水岭梗死; 临床疗效; 神经功能缺损
Keywords:
butylphthalide; cerebral watershed infarction; clinical efficacy; neurological deficits
分类号:
R743.33
DOI:
10.7683/xxyxyxb.2022.10.013
文献标志码:
A
摘要:
目的　探讨丁苯酞治疗颈内动脉系统脑分水岭梗死(CWI)的临床疗效。方法　选择2021年1月至2021年12月于浏阳市集里医院住院治疗的颈内动脉系统CWI患者80例为研究对象，根据治疗方法将患者分为对照组和观察组，每组40例。2组患者均积极辅助神经康复治疗，控制血糖、高脂血症等血管病危险因素，根据病情酌情控制血压。对照组患者给予常规治疗，包括：口服硫酸氢氯吡格雷片75 mg、阿司匹林肠溶片100 mg、阿托伐他汀钙片20 mg，每日1次；静脉注射羟乙基淀粉500 mL，每日1次。在对照组患者治疗基础上，观察组患者给予丁苯酞注射液100 mL，静脉滴注，每日2次。2组患者均连续治疗14 d。分别于治疗前及治疗7、14 d后采用美国国立卫生研究院卒中量表（NIHSS）评估2组患者的脑神经功能，治疗14 d后评估2组患者的临床疗效，并计算总有效率，治疗后3个月采用改良Rankin量表(mRS)评估2组患者的预后情况。结果　治疗前2组患者的NIHSS评分比较差异无统计学意义（P>0.05）；2组患者治疗7、14 d后的NIHSS评分显著低于治疗前，治疗14 d后的NIHSS评分显著低于治疗 7 d后（P<0.05）；治疗7、14 d后，观察组患者的NIHSS评分显著低于对照组（P<0.05）。治疗14 d后，对照组和观察组患者的有效率分别为 65.0%（26/40）和90.0%（36/40），观察组患者的有效率显著高于对照组（χ2=7.168，P<0.05）。治疗后3个月，观察组患者的mRS评分显著低于对照组（P<0.05）。结论　丁苯酞治疗颈内动脉系统CWI患者临床疗效较好，可促进患者神经功能恢复，改善预后。
Abstract:
Objective　To investigate the clinical efficacy of butylphthalide in the treatment of patients with cerebral watershed infarction (CWI) of internal carotid artery system.Methods　A total of 80 patients with CWI of the internal carotid artery system who were hospitalized in Jili Hospital of Liuyang City from January 2021 to December 2021 were selected as the research subjects.According to the treatment method,the patients were divided into the control group and the observation group,with 40 cases in each group.The patients in both groups were actively assisted with neurorehabilitation therapy,controlled blood sugar,hyperlipidemia and other risk factors of vascular disease,and controlled blood pressure as appropriate according to the condition.The patients in the control group were given conventional therapy,including oral clopidogrel hydrogen sulfate tablet 75 mg,aspirin enteric-coated tablet 100 mg,atorvastatin calcium tablet 20 mg,once a day;intravenous injection of hydroxyethyl starch 500 mL,once a day.On the basis of the treatment in the control group,the patients in the observation group were given intravenous drip of butylphthalide injection,100 mL each time,twice a day.The patients in the both groups received continuous treatment for 14 days.Before treatment and after 7,14 days of treatment,the cranial nerve function of patients in the two groups was evaluated by the National Institute of Health stroke scale (NIHSS).After 14 days of treatment,the clinical efficacy of patients in the two groups was evaluated,and the total effective rate was calculated.Three months after treatment,the prognosis of patients in the two groups was evaluated by the modified Rankin scale (mRS).Results　Before treatment,there was no significant difference in the NIHSS scores of patients between the two groups (P>0.05).The NIHSS scores of patients in the two groups after 7 days and 14 days of treatment were significantly lower than those before treatment,and the NIHSS scores of patients in the two groups after 14 days of treatment were significantly lower than those after 7 days of treatment（P<0.05）.After 7 days and 14 days of treatment,the NIHSS scores of patiens in the observation group were significantly lower than those in the control group（P<0.05）.After 14 days of treatment,the effective rate of patients in the control group and the observation group was 65.0%(26/40) and 90.0%(36/40),respectively;the effective rate of patients in the observation group was significantly higher than that in the control group (χ2=7.168,P<0.05).After 3 months of treatment,the mRS score of patients in the observation group was significantly lower than that in the control group（P<0.05）.Conclusion　Butylphthalide has a good clinical effect in the treatment of CWI of internal carotid artery system,which can promote the recovery of the patient′s neurological function and improve the prognosis.

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更新日期/Last Update: 2022-10-05