[1]李广鹏,秦　蕾,吴　畏,等.生长抑素联合阿托伐他汀治疗急性胰腺炎疗效观察[J].新乡医学院学报,2022,39(9):855-858.[doi:10.7683/xxyxyxb.2022.09.012]
　LI Guangpeng,QIN Lei,WU Wei,et al.Efficacy of somatostatin combined with atorvastatin in the treatment of acute pancreatitis[J].Journal of Xinxiang Medical University,2022,39(9):855-858.[doi:10.7683/xxyxyxb.2022.09.012]
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生长抑素联合阿托伐他汀治疗急性胰腺炎疗效观察
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
39
期数:
2022年9
页码:
855-858
栏目:
临床研究
出版日期:
2022-09-05

文章信息/Info

Title:
Efficacy of somatostatin combined with atorvastatin in the treatment of acute pancreatitis
作者:
李广鹏1; 秦　蕾2; 吴　畏1; 石金河1; 杨飞云1
（1.新乡医学院第一附属医院急诊科，河南　卫辉　453100；2.新乡医学院第一附属医院消化内二科，河南　卫辉　453100）
Author(s):
LI Guangpeng1; QIN Lei2; WU Wei1; SHI Jinhe1; YANG Feiyun1
(1.Department of Emergency,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,Henan Province,China;2.The Second Department of Gastroenterology,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,Henan Province,China)
关键词:
急性胰腺炎; 生长抑素; 阿托伐他汀; 胰腺功能
Keywords:
acute pancreatitis; somatostatin; atorvastatin; pancreas function
分类号:
R451
DOI:
10.7683/xxyxyxb.2022.09.012
文献标志码:
A
摘要:
目的　探讨生长抑素联合阿托伐他汀治疗急性胰腺炎患者的效果及对胰腺功能的影响。方法　选择2019年1月至2020年12月新乡医学院第一附属医院收治的90例急性胰腺炎患者为研究对象，按照随机数字表法将患者分为对照组和观察组，每组45例。2组患者均接受禁饮禁食、胃肠减压、补充水电解质、维持酸碱平衡及抗感染等常规治疗，对照组患者在常规治疗基础上给予3 mg生长抑素静脉泵注，每日1次；观察组患者在对照组治疗基础上口服阿托伐他汀20 mg，每日1次。2组患者均治疗1周。比较2组患者的临床疗效以及胰腺组织血流量(BF)、血容量(BV)和毛细血管表面通透性(PS)等胰腺功能指标和并发症发生率。结果　对照组和观察组患者治疗有效率分别为77.8%（35/45）、91.1%（41/45）；观察组患者治疗有效率显著高于对照组(χ2=4.232，P<0.05)。治疗前，2组患者胰腺组织BF、BV、PS比较差异无统计学意义(P>0.05)；治疗后，2组患者胰腺组织BF和BV显著高于治疗前，PS显著低于治疗前(P<0.05)；治疗后，观察组患者胰腺组织BF和BV高于对照组，PS低于对照组(P<0.05)。对照组和观察组患者并发症发生率分别为17.8%（8/45）、4.4%（3/45）；观察组患者并发症发生率显著低于对照组(χ2=4.050，P<0.05)。结论　生长抑素联合阿托伐他汀治疗急性胰腺炎的临床效果显著,可显著改善患者的胰腺功能，并减少并发症发生。
Abstract:
Objective　To investigate the effect of somatostatin combined with atorvastatin in the treatment of acute pancreatitis (AP) and its effect on pancreatic function.Methods　A total of 90 patients with AP admitted to the First Affiliated Hospital of Xinxiang Medical University from January 2019 to December 2020 were selected as the research subjects,and they were divided into the control group and the observation group according to the random number table method,with 45 cases in each group.The patients in the two groups received routine treatment including fasting,gastrointestinal decompression,water and electrolyte supplementation,acid-base balance maintenance and anti-infection,etc.;on the basis of routine treatment,the patients in the control group were given intravenous injection of 3 mg somatostatin,once a day;on the basis of the treatment of the control group,the patients in the observation group were given 20 mg atorvastatin orally,once a day.The patients in the two groups were treated for 1 week.The clinical effect,pancreatic function including pancreatic tissue blood flow(BF),blood volume(BV) and capillary surface permeability(PS)and the incidence of complications of patients between the two groups were compared.Results　The effective rate of patients in the control group and the observation group was 77.8% (35/45),91.1% (41/45),respectively;the effective rate of patients in the observation group was significantly higher than those in the control group（χ2=4.232,P<0.05).Before treatment,there was no significant difference in BF,BV and PS of patients between the two groups (P>0.05);after treatment,the BF and BV in pancreatic tissue of patients in the two groups were significantly higher than those before treatment,and the PS was significantly lower than that before treatment (P<0.05);after treatment,BF and BV in pancreatic tissue of patients in the observation group were significantly higher than those in the control group,and PS was significantly lower than that in the control group (P<0.05).The incidence of complications of patients in the control group and observation group was 17.8% (8/45),4.4% (3/45),respectively;the incidence of complications of patients in the observation group was significantly lower than that in the control group（χ2=4.050,P<0.05).Conclusion　Somatostatin combined with atorvastatin has a significant clinical effect in the treatment of AP,which can improve the pancreatic function and reduce the complications of patients.

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更新日期/Last Update: 2022-09-05