[1]费鹏鸽,李智花,李文强,等.事件相关电位P300对脑卒中后抑郁患者认知功能障碍的评估价值[J].新乡医学院学报,2022,39(6):523-527.[doi:10.7683/xxyxyxb.2022.06.005]
　FEI Pengge,LI Zhihua,LI Wenqiang,et al.Value of event-related potential P300 in evaluating cognitive dysfunction of patients with post-stroke depression[J].Journal of Xinxiang Medical University,2022,39(6):523-527.[doi:10.7683/xxyxyxb.2022.06.005]
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事件相关电位P300对脑卒中后抑郁患者认知功能障碍的评估价值
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
39
期数:
2022年6
页码:
523-527
栏目:
临床研究
出版日期:
2022-06-05

文章信息/Info

Title:
Value of event-related potential P300 in evaluating cognitive dysfunction of patients with post-stroke depression
作者:
费鹏鸽1; 李智花2; 李文强3; 穆俊林4; 宋景贵1
(1.新乡医学院第二附属医院神经内科，河南　新乡　453002；2.新乡市第一人民医院神经内科，河南　新乡　453000；3.河南省生物精神病学重点实验室，河南　新乡　453002；4.新乡医学院第二附属医院神经电生理科，河南　新乡　453002）
Author(s):
FEI Pengge1; LI Zhihua2; LI Wenqiang3; MU Junlin4; SONG Jinggui1
(1.Department of Neurology,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan Province,China;2.Department of Neurology,the First People′s Hospital of Xinxiang City,Xinxiang 453000,Henan Province,China;3.The Key Laboratory of Biological Psychiatry of Henan Province,Xinxiang 453002,Henan Province,China;4.Department of Neuroelectrophysiology,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan Province,China)
关键词:
缺血性脑卒中; 卒中后抑郁; 事件相关电位P300; 认知功能障碍
Keywords:
ischemic stroke; post-stroke depression; event-related potential P300; cognitive dysfunction
分类号:
R743
DOI:
10.7683/xxyxyxb.2022.06.005
文献标志码:
A
摘要:
目的　探讨事件相关电位P300对脑卒中后抑郁（PSD）患者认知功能障碍的评估价值。方法　选择2017年1月至2018年5月新乡医学院第二附属医院收治的124例缺血性脑卒中患者为研究对象。采用24项汉密尔顿抑郁量表（HAMD-24）对患者进行评估，根据HAMD-24评分将患者分为PSD组（n=63，HAMD-24评分>20分）和脑卒中组（n=61，HAMD-24评分<8分）；选择同期本院体检健康者61例为健康对照组。采用丹迪Keypoint4 诱发电位仪检测3组受试者事件相关电位P300的潜伏期及波幅。结果　治疗前、治疗14 d后，PSD组和脑卒中组患者的P300潜伏期显著长于健康对照组，PSD组患者的P300潜伏期显著长于脑卒中组（P<0.05）；PSD组和脑卒中组患者治疗14 d后的P300潜伏期显著短于治疗前（P<0.05）。治疗前、治疗14 d后，PSD组和脑卒中组患者P300波幅显著低于健康对照组，PSD组患者P300波幅显著低于脑卒中组（P<0.05）；PSD组和脑卒中组患者治疗14 d后的P300波幅显著高于治疗前（P<0.05）。治疗前，PSD组患者P300检测异常率为85.7%（54/63），脑卒中组患者P300检测异常率68.9%（42/61）；PSD组患者治疗前P300检测异常率显著高于脑卒中组（χ2=5.040，P<0.05）；治疗14 d后，PSD组患者P300检测异常率为77.8%（49/63），脑卒中组患者P300检测异常率为60.7%（37/61）；PSD组患者治疗14 d后P300检测异常率显著高于脑卒中组（χ2=4.275，P<0.05）；治疗14 d后，2组患者P300检测异常率与治疗前比较差异均无统计学意义（χ2=1.330、0.581,P>0.05）。结论　事件相关电位P300可作为PSD患者筛查早期认知功能障碍的辅助指标。
Abstract:
Objective　To investigate the value of event-related potential P300 in evaluating cognitive dysfunction of patients with post-stroke depression (PSD).Methods　A total of 124 patients with ischemic stroke admitted to the Second Affiliated Hospital of Xinxiang Medical University from January 2017 to May 2018 were selected as the study subjects.The patients were assessed with 24 item Hamilton depression scale (HAMD-24),and they were divided into PSD group (n=63,HAMD-24 score>20) and stroke group (n=61,HAMD-24 score<8) according to the HAMD-24 score;and 61 healthy subjects in our hospital in the same period were selected as the healthy control group.The latency and amplitude of event-related potential P300 of the subjects in the three groups were detected by using the Dandi Keypoint4 induced potentiometer.Results　Before and after 14 days of treatment,the latency of P300 of patients in the PSD group and stroke group was significantly longer than that in the healthy control group,and the latency of P300 of patients in the PSD group was significantly longer than that in the stroke group (P<0.05).The latency of P300 of patients in the PSD group and stroke group after 14 days of treatment was significantly shorter than that before treatment (P<0.05).Before and after 14 days of treatment,the amplitude of P300 of patients in the PSD group and stroke group was significantly lower than that in the healthy control group,and the amplitude of P300 of patients in the PSD group was significantly lower than that in the stroke group (P<0.05).The amplitude of P300 of patients in the PSD group and stroke group after 14 days of treatment was significantly higher than that before treatment (P<0.05).Before treatment,the abnormal rate of P300 of patients in the PSD group was 85.7% (54/63),and the abnormal rate of P300 of patients in the stroke group was 68.9% (42/61);the abnormal rate of P300 of patients in the PSD group was significantly higher than that in the stroke group (χ2=5.040,P<0.05).After 14 days of treatment,the abnormal rate of P300 of patients in the PSD group was 77.8% (49/63) and the abnormal rate of P300 of patients in stroke group was 60.7% (37/61);the abnormal rate of P300 of patients in the PSD group was significantly higher than that in the stroke group after 14 days of treatment (χ2= 4.275,P<0.05);after 14 days of treatment,there was no statistical difference in abnormal rate of P300 of patients compared with that before treatment in the two groups (χ2=1.330,0.581;P>0.05).Conclusion　Event-related potential P300 can be used as an auxiliary indicator for screening early cognitive dysfunction in PSD patients.

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更新日期/Last Update: 2022-06-05