[1]杨 鑫,杨道坤.Toll样受体在慢性乙型肝炎患者免疫损伤中的作用研究进展[J].新乡医学院学报,2022,39(4):392-395.[doi:10.7683/xxyxyxb.2022.04.019]
 YANG Xin,YANG Daokun.Research progress on the role of toll like receptor in immunological injury of patients with chronic hepatitis B[J].Journal of Xinxiang Medical University,2022,39(4):392-395.[doi:10.7683/xxyxyxb.2022.04.019]
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Toll样受体在慢性乙型肝炎患者免疫损伤中的作用研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
39
期数:
2022年4
页码:
392-395
栏目:
综述
出版日期:
2022-04-05

文章信息/Info

Title:
Research progress on the role of toll like receptor in immunological injury of patients with chronic hepatitis B
作者:
杨 鑫杨道坤
(新乡医学院第一附属医院感染科,河南 卫辉 453100)
Author(s):
YANG XinYANG Daokun
(Department of Infectious Disease,the Affiliated First Hospital of Xinxiang Medical University,Weihui 453100,Henan Province,China)
关键词:
乙型肝炎病毒免疫应答Toll样受体
Keywords:
hepatitis B virusimmune responsetoll-like receptor
分类号:
R512.6+2
DOI:
10.7683/xxyxyxb.2022.04.019
文献标志码:
A
摘要:
乙型肝炎病毒(HBV)感染是世界关注的健康问题,也是我国慢性肝病的主要病因。目前,慢性乙型肝炎(CHB)抗病毒治疗的目的是达到临床功能性治愈,但抗病毒治疗无法将共价闭合的环状DNA从肝细胞中彻底根除,而且HBV感染患者主要表现为免疫功能异常,使得患者体内病毒清除困难。Toll样受体(TLRs)与HBV感染患者的机体免疫损伤有关,TLRs通过免疫途径对HBV DNA的清除起关键作用,这为HBV感染的抗病毒免疫治疗提供了相应的理论基础。本文主要对TLRs在CHB发展及抗病毒免疫治疗中的作用进行综述,为研发更有效的抗HBV方案提供理论依据。
Abstract:
Hepatitis B virus (HBV) infection is a worldwide health problem,and it is also the main cause of chronic liver disease in China.At present,the greatest goal of antiviral treatment of chronic hepatitis B (CHB) is to achieve clinical functional cure,but antiviral treatment can′t completely eradicate covalently closed circular DNA from hepatocytes.The patients with HBV infection are mainly characterized by abnormal immune function,which makes it difficult to clear the virus in patients.Toll-like receptors (TLRs) are related to immunological injury in patients with HBV infection.TLRs play a key role in the immune clearance of HBV DNA,which provides a corresponding theoretical basis for antiviral immunotherapy of HBV infection.This paper mainly reviews the role of TLRs in the development and antiviral immunotherapy of CHB,so as to provide a theoretical basis for developing more effective antiviral treatment.

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更新日期/Last Update: 2022-04-05