[1]朱佳丽,鲁素彩.小檗碱治疗溃疡性结肠炎研究进展[J].新乡医学院学报,2022,39(2):187-191.[doi:10.7683/xxyxyxb.2022.02.018]
　ZHU Jiali,LU Sucai.Research progress of berberine in the treatment of ulcerative colitis[J].Journal of Xinxiang Medical University,2022,39(2):187-191.[doi:10.7683/xxyxyxb.2022.02.018]
点击复制

小檗碱治疗溃疡性结肠炎研究进展
分享到：

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
39
期数:
2022年2
页码:
187-191
栏目:
综述
出版日期:
2022-02-05

文章信息/Info

Title:
Research progress of berberine in the treatment of ulcerative colitis
作者:
朱佳丽; 鲁素彩
(河北大学附属医院消化科，河北　保定　071000)
Author(s):
ZHU Jiali; LU Sucai
（Department of Gastroenterology，Affiliated Hospital of Hebei University,Baoding 071000,Hebei Province，China）
关键词:
小檗碱; 溃疡性结肠炎; 肠道菌群; 肠黏膜屏障
Keywords:
berberine; ulcerative colitis; intestinal microflora; intestinal mucosal barrier
分类号:
R574.62
DOI:
10.7683/xxyxyxb.2022.02.018
文献标志码:
A
摘要:
溃疡性结肠炎（UC）是一种原因不明的慢性结肠炎症，其病变主要局限于结肠的黏膜层和黏膜下层。目前，UC的病因尚不完全明确，多数学者认为其发病与遗传、免疫、环境、微生物有关，尚无特效的治疗方法。小檗碱是从中药黄连中提取的主要成分，可用于抗炎、抗微生物、抗肿瘤、降血压、降血糖、降血脂等治疗。研究发现，小檗碱对UC有明确疗效，其作用机制包括抗炎、调节肠道菌群、修复肠黏膜屏障、调节免疫反应等多种途径，但各方面研究尚不完善。本文就小檗碱治疗UC的作用及机制的研究进展加以综述。
Abstract:
Ulcerative colitis (UC) is a chronic colon inflammation of unknown cause，whose lesions are mainly confined to the mucosal and submucosal layers of the colon.At present，the etiology of UC is not completely clear，and most scholars believe that its pathogenesis is related to genetics，immunity，environment and microorganisms，and there is no specific treatment method.Berberine is the main component extracted from Coptis chinensis，which can be used for anti-inflammatory，anti-microbial，anti-tumor，blood pressure reduction，blood sugar reduction blood lipid reduction and other treatments.At present,the study has found that berberine has a clear curative effect on UC,and its action mechanism includes anti-inflammatory，regulating intestinal flora，repairing intestinal mucosal barrier，regulating immune response，and so on，but the research in various aspects is not perfect.This paper reviews the research progress of the effect and mechanism of berberine in the treatment of UC.

参考文献/References:

［1］　梁笑楠,尹凤荣,张晓岚.炎症性肠病诊断与治疗的共识意见(2018年,北京)溃疡性结肠炎部分解读［J］.临床荟萃,2018,33(11):987-990.
LIANG X N,YIN F R,ZHANG X L.Interpretation of the consensus on diagnosis and management of inflammatory bowel disease(Beijing,2018) from the perspective of diagnosis of ulcerative colitis［J］.Clin Focus,2018,33(11):987-990.
［2］　WANG X Y,XIAO S Y,JIANG Z W,et al.An ultrathin 2D Yb(III) metal-organic frameworks with strong electrochemiluminescence as a “on-off-on” platform for detection of picric acid and berberine chloride form［J］.Talanta,2021,234:122625.
［3］　于浩,杜建玲.小檗碱的药理作用及机制的研究现状［J］.中国现代应用药学,2020,37(4):501-507.
YU H,DU J L.Research progress on pharmacological effect and mechanism action of berberine［J］.Chin J Mod Appl Pharm,2020,37(4):501-507.
［4］　杜小东，罗利飞．溃疡性结肠炎患者肠道菌群和肠黏膜屏障的变化及益生菌的干预作用［J］.中国微生态学杂志，2019，31(2):193-196．
DU X D,LUO L F.Changes in intestinal flora and intestinal mucosal barrier of patients with ulcerative colitis and the effect of probiotics intervention［J］.Chin J Microecol,2019,31(2):193-196.
［5］　TANG Q,CANG S,JIAO J,et al.Integrated study of metabolomics and gut metabolic activity from ulcerative colitis to colorectal cancer:the combined action of disordered gut microbiota and linoleic acid metabolic pathway might fuel cancer［J］.J Chromatogr A,2020,1629:461503.
［6］　崔海宏,陈村龙,王继德,等.双歧杆菌影响溃疡性结肠炎患者肠黏膜的研究［J］.中华内科杂志,2003,42(8):29-32.
CUI H H,CHEN C L,WANG J D,et al.The effects of bifidobacterium on the intestinal mucosa of the patients with ulcerative colitis［J］.Chin J Intern Med,2003,42(8):29-32.
［7］　林云钗,彭峰,周强,等.2型糖尿病患者肠道菌群变化与胰腺内分泌激素的相关性［J］.中华高血压杂志,2020,28(12):1157-1162.
LIN Y C,PENG F ZHOU Q,et al.Association of intestinal flora and pancreatic endocrine secretion in patients with type 2 diabetes［J］.Chin J Hypertens,2020,28(12):1157-1162.
［8］　熊红萍,徐静,周强,等.小檗碱对口服降糖药糖尿病患者的胃肠激素及肠道菌群的影响［J］.中医药学报,2019,47(1):64-68.
XIONG H P,XU J,ZHOU Q,et al.Effect of berberine on gastrointestinal hormones and intestinal flora in DM patients intervened by antidiabetic agents［J］.Acta Chin Med Pharm,2019,47(1):64-68.
［9］　林媛,司书毅,蒋建东.小檗碱的抗菌作用［J］.药学学报,2018,53(2):163-168.
LIN Y,SI S Y,JIANG J D.Antibacterial activity of berberine［J］.Acta Pharm Sin,2018,53(2):163-168.
［10］　ZHANG Y,WANG J,HOU D,et al.To assess the effective and safety of berberine hydrochloride in ulcerative colitis:a protocol for systematic review and meta-analysis［J］.Medicine,2020,99(49):e23482.
［11］　ZHAI L X,HUANG T,XIAO H T，et al.Berberine suppresses colonic inflammation in dextran sulfate sodium-induced murine colitis through inhibition of cytosolic phospholipase A2 activity［J］.Front Pharmacol,2020,11:576496.
［12］　LI C,AI G,WANG F,et al.Oxyberberine,a novel gut microbiota-mediated metabolite of berberine,possesses superior anti-colitis effect:impact on intestinal epithelial barrier,gut microbiota profile and TLR4-MyD88-NF-κB pathway［J］.Pharmacol Res,2020,152:104603.
［13］　HU J C E,WEIB F,BOJARSKI C,et al.Expression of tricellular tight junction proteins and the paracellular macromolecule barrier are recovered in remission of ulcerative colitis［J］.BMC Gastroenterol,2021,21(1):141.
［14］　沈雁,李思,钟继红,等.小檗碱对溃疡性结肠炎小鼠结肠组织紧密连接蛋白claudin-1表达的影响［J］.预防医学,2017,29(11):1098-1103.
SHEN Y,LI S,ZHONG J H,et al.Effects of berberine extracted from Chinese Goldthread Rhizome on the expression of claudin-1 in ulcerative colitis mice［J］.Prev Med,2017,29(11):1098-1103.
［15］　REN M T,GU M L,ZHOU X X,et al.Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis［J］.World J Gastroenterol,2019,25(38):5800-5813.
［16］　SHEN Y,LIU Y C,WANG Z L,et al.Effect of berberine from Coptis chinensis on apoptosis of intestinal epithelial cells in a mouse model of ulcerative colitis:role of endoplasmic reticulum stress［J］.Evid Based Complement Alternat Med,2020,2020:3784671.
［17］　沈雁,吕宾.甘草酸苷调控内质网应激caspase-12凋亡信号通路缓解溃疡性结肠炎结肠炎性反应的研究［J］.中华中医药杂志,2020,35(8):3872-3877.
SHEN Y,LYU B.Study of glycyrrhizin regulating caspase-12 apoptosis signaling pathway of endoplasmic reticulum stress to alleviate the colonic inflammatory response in ulcerative colitis［J］.Chin J Tradit Chin Med Pharm,2020,35(8):3872-3877.
［18］　ZHANG B,SU X Y,XIE Z Y,et al.Inositol-requiring kinase 1 regulates apoptosis via inducing endoplasmic reticulum stress in colitis epithelial cells［J］.Dig Dis Sci,2020,66(9):3015-3025.
［19］　THAPA B,PAK S,KWON H J,et al.Decursinol angelate ameliorates dextran sodium sulfate-induced colitis by modulating type 17 helper T cell responses［J］.Biomol Ther(Seoul),2019,27(5):466-473.
［20］　唐庆,范恒,张丽娟,等.小檗碱对结肠炎小鼠Th17/Treg细胞分化及IL-35的影响［J］.现代中西医结合杂志,2019,28(1):1-5.
TANG Q,FAN H,ZHANG L J,et al.Effect of berberine on Th17/Treg cell differentiation and IL-35 in experimental colitis mice［J］.Modern J Integr Tradit Chin West Med,2019,28(1):1-5.
［21］　SHIRAZI K M,KHAYATI S,BINAZIR B M,et al.Relationship between microalbuminuria and disease activity in patients with ulcerative colitis［J］.Middle East J Dig Dis,2020,12(1):34-38.
［22］　钱卫珍,张卫峰.参苓白术散联合美沙拉嗪对溃疡性结肠炎儿童和青少年炎症因子与免疫功能的影响［J］.医药导报,2019,38(5):584-588.
QIAN W Z,ZHANG W F.Effect of Shenlingbaizhu Powder combined with Mesalazin on inflammatory factors and immune function in children and adolescents with ulcerative colitis［J］.Herald Med,2019,38(5):584-588.
［23］　徐晓帆.小檗碱对葡聚糖硫酸钠诱导的小鼠肠炎的治疗效果与机制［D］.武汉：华中农业大学,2021.
XU X F.Therapeutic effect and mechanism of berberine on dextran sodium sulfate-induced intestinal inflammation in mice［D］.Wuhan:Huazhong Agricultural University,2021.
［24］　张仁霞，傅永锦，梁基智，等.小檗碱治疗大鼠免疫复合性溃疡性结肠炎及下调炎性细胞因子作用［J］.临床医学工程，2014,21（11）：1406-1409.
ZHANG R X,FU Y J,LIANG J Z,et al.Studies of berberine on therapeutic effect and inhibiting expression of cytokines in rats with ulcerative colitis induced by immune complex-combined TNBS/ethanol［J］.Clin Med Eng,2014,21(11):1406-1409.
［25］　LI Y H,XIAO H T,HU D D,et al.Berberine ameliorates chronic relapsing dextran sulfate sodium-induced colitis in C57BL/6 mice by suppressing Th17 responses［J］.Pharmacol Res,2016,110:227-239.
［26］　陈坚,刘杰.小檗碱的临床新用途及其作用机制研究进展［J］.上海医药,2016,37(3):26-30.
CHEN J,LIU J.The novel applications and pharmological advances of berberine［J］.Shanghai Med Pharm J,2016,37(3):26-30.
［27］　台卫平,罗和生.短链脂肪酸在溃疡性结肠炎病因及治疗中的作用［J］.世界华人消化杂志,2000,8(1):96-97.
TAI W P,LUO H S.Role of short-chain fatty acids in etiology and treatment of ulcerative colitis［J］.World J Chin Digest,2000,8(1):96-97.
［28］　HARIG J M,SOERGEL K H,BARRY J A,et al.Transport of propionate by human ileal brush-border membrane vesicles［J］.Am J Physiol,1991,260(5 Pt 1):G776-G782.
［29］　马雯钰.小檗碱与运动通过SCFAs和免疫调节通路协同抑制乳腺癌生长机制研究［D］.重庆：西南大学,2020.
MA W Y.Berberine and regular exercise synergetically inhibit the progression of breast cancer by mediating short chain fatty acids and immune regulation［D］.Chongqing:Southwestern University,2020.
［30］　何馨怡,帅世全,党万太,等.小檗碱调控炎症的研究进展［J］.西部医学,2018,30(11):1714-1717.
HE X Y,SHUAI S Q,DANG W T,et al.Research progress of berberine in the regulation of inflammation［J］.Med J West China,2018,30(11):1714-1717.
［31］　KOTANI A,MIYAGUCHI Y,KOHAMA M,et al.Determination of short-chain fatty acids in rat and human feces by high-perfor-mance liquid chromatography with electrochemical detection［J］.Anal Sci,2009,25(8):1007-1011.
［32］　SABATINO A D,SANTILLI F,GUERCI M,et al.Oxidative stress and thromboxane-dependent platelet activation in inflammatory bowel disease:effects of anti-TNF-α treatment［J］.Thromb Haemost,2016,116(3):486-495.
［33］　LIU Y,WANG X Y,YANG X,et al.Lung and intestine:a specific link in an ulcerative colitis rat model［J］.Gastroenterol Res Pract,2013,2013:124530.
［34］　CARTY E,MACEY M,MCCARTNEY S A,et al.Ridogrel,a dual thromboxane synthase inhibitor and receptor antagonist:anti-inflammatory profile in inflammatory bowel disease［J］.Aliment Pharmacol Ther,2000,14(6):807-817.
［35］　PANDEY M K,SUNG B,KUNNUMAKKARA A B,et al.Berbeine modifies cysteine 179 of IKappaBalpha kinase,suppresses nuclear factor-kappaB-regulated antiapoptotic gene products,and potentiates apoptosis［J］.Cancer Res,2008,68(13):5370-5379.
［36］　HONG T，YANG Z,LV C F,et al.Suppressive effect of berberine on experimental dextran sulfate sodium-induced colitis［J］.Immunopharmacol Immunotoxicol,2012,34(3):391-397.
［37］　HAO X,YAO A,GONG J,et al.Berberine ameliorates proinflammatory cytokine-induced endoplasmic reticulum stress in human intestinal epithelial cells in vitro［J］.Inflammation,2012,35(3):841-849.
［38］　ZHU X Y,ZHANG C L,LIN Y K,et al.Ferruginol alleviates inflammation in dextran sulfate sodium-induced colitis in mice through inhibiting COX-2,MMP-9 and NF-κB signaling［J］.Asian Pac J Tropi Biomed,2020,10(7):308-315.
［39］　KIMURA Y.Preventive effects of Mallotus japonicus cortex extracts on dextran sulfate sodium-induced ulcerative colitis in C57 BL/6J mice［J］.Natur Prod J,2020,10(2):177-185.
［40］　杜鹏程,韩璠,谷九莲.溃疡性结肠炎患者血清单核细胞趋化蛋白-1、高迁移率族蛋白B1、肿瘤坏死因子-α、白细胞介素-6和白细胞介素-10水平与肠道菌群的相关性［J］.新乡医学院学报,2021,38(4):370-373.
DU P C,HAN F,GU J L.Correlation of serum monocyte chemotaxis protein-1,high-mobility family protein B1,tumor necrosis factor-α,interleukin-6,and interleukin-10 levels in patients with ulcerative colitis［J］.J Xinxiang Med Univ,2021,38(4):370-373.
［41］　WANG Q C,LIU W X,YUE Y,et al.Proteoglycan from Bacillus sp. BS11 inhibits the inflammatory response by suppressing the MAPK and NF-κB pathways in lipopolysaccharide-induced RAW264.7 macrophages［J］.Mar Drugs,2020,18(12):585.

相似文献/References:

[1]侯再恩.肠炎平治疗溃疡性结肠炎58例[J].新乡医学院学报,2003,20(05):376.
[2]侯再恩.肠炎平治疗溃疡性结肠炎58 例[J].新乡医学院学报,2003,20(05):376.
[3]张小毅,刘瑞丽,韩效林,等.愈疡液治疗大鼠溃疡性结肠炎的实验研究[J].新乡医学院学报,2003,20(01):021.
[4]张小毅,刘瑞丽,韩效林,等.愈疡液治疗大鼠溃疡性结肠炎的实验研究[J].新乡医学院学报,2003,20(01):021.
[5]陈凤玲,杨志红,王宣春,等.小檗碱增加亲脂素在巨噬细胞的表达[J].新乡医学院学报,2007,24(06):544.
[6]柯贤胜.美沙拉嗪对溃疡性结肠炎患者血清白细胞介素-6、白细胞介素-8及肿瘤坏死因子-α的影响 [J].新乡医学院学报,2012,29(12):950.
[7]张　伟,杨银利,张　林,等.青柏溃结汤灌肠对溃疡性结肠炎大肠湿热证患者结肠黏膜愈合及血清炎性因子水平的影响[J].新乡医学院学报,2018,35(6):474.[doi:10.7683/xxyxyxb.2018.06.006]
　ZHANG Wei,YANG Yin-li,ZHANG Lin,et al.Effect of Qingbaikuijietang enema on colonic mucosa healing and serum inflammatory factors in patients with ulcerative colitis and large intestine damp-heat syndrome[J].Journal of Xinxiang Medical University,2018,35(2):474.[doi:10.7683/xxyxyxb.2018.06.006]
[8]杜鹏程,韩　璠,谷九莲.溃疡性结肠炎患者血清单核细胞趋化蛋白-1、高迁移率族蛋白B1、肿瘤坏死因子-α、白细胞介素-6和白细胞介素-10水平与肠道菌群的相关性[J].新乡医学院学报,2021,38(4):370.[doi:10.7683/xxyxyxb.2021.04.016]
　DU Pengcheng,HAN Fan,GU Jiulian.Correlation between serum monocyte chemoattractant protein-1,high mobility group protein B1,tumor necrosis factor-α,interleukin-6,interleukin-10 levels and intestinal flora in patients with ulcera-tive colitis[J].Journal of Xinxiang Medical University,2021,38(2):370.[doi:10.7683/xxyxyxb.2021.04.016]
[9]于佳卉,毛光兰,王庆志,等.沉默信号调节蛋白6在溃疡性结肠炎小鼠结肠组织中的表达及意义[J].新乡医学院学报,2021,38(9):806.[doi:10.7683/xxyxyxb.2021.09.002]
　YU Jiahui,MAO Guanglan,WANG Qingzhi,et al.Expression and role of silent information regulator 6 in colon tissues of mice with ulcerative colitis[J].Journal of Xinxiang Medical University,2021,38(2):806.[doi:10.7683/xxyxyxb.2021.09.002]
[10]孙红玲,吴　娇.小檗碱的药理作用研究进展[J].新乡医学院学报,2020,37(1):091.[doi:10.7683/xxyxyxb.2020.01.022]

更新日期/Last Update: 2022-02-05