[1]周翠翠,吕风华,王现伟.血清同型半胱氨酸和胱抑素C对慢性心力衰竭患者早期肾损伤的诊断价值[J].新乡医学院学报,2021,38(11):1025-1028.[doi:10.7683/xxyxyxb.2021.11.005]
　ZHOU Cuicui,LYU Fenghua,WANG Xianwei.Clinical value of serum homocysteine and cystatin C in the diagnosis of early renal injury in patients with chronic heart failure[J].Journal of Xinxiang Medical University,2021,38(11):1025-1028.[doi:10.7683/xxyxyxb.2021.11.005]
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血清同型半胱氨酸和胱抑素C对慢性心力衰竭患者早期肾损伤的诊断价值
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
38
期数:
2021年11
页码:
1025-1028
栏目:
临床研究
出版日期:
2021-11-05

文章信息/Info

Title:
Clinical value of serum homocysteine and cystatin C in the diagnosis of early renal injury in patients with chronic heart failure
作者:
周翠翠1; 吕风华1; 王现伟2
（1.新乡医学院第一附属医院心血管内科，河南　卫辉　453100；2.新乡医学院医用组织再生重点实验室，河南　新乡 453003）
Author(s):
ZHOU Cuicui1; LYU Fenghua1; WANG Xianwei2
(1.Department of Cardiology,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,Henan Province,China
2.Key Laboratory of Medical Tissue Regeneration,Xinxiang Medical University,Xinxiang 453003,Henan Province,China)
关键词:
血清同型半胱氨酸; 血清胱抑素C; 慢性心力衰竭; 早期肾损伤
Keywords:
serum homocysteineserum cystatin Cchronic heart failureearly kidney injury
分类号:
R541.6
DOI:
10.7683/xxyxyxb.2021.11.005
文献标志码:
A
摘要:
目的　探讨血清同型半胱氨酸（Hcy）、胱抑素C（Cys-C）水平在诊断慢性心力衰竭（CHF）患者早期肾损伤中的临床价值。方法　选择2018年5月至2019年12月于新乡医学院第一附属医院就诊的CHF患者98例为研究对象。根据肾小球滤过率（GFR）将患者分为CHF组(n=53)和CHF合并早期肾损伤组(n=45)；另选择同期体检健康者为健康对照组(n=66)。采用酶循环法检测所有受试者血清Hcy水平，采用胶乳增强免疫比浊法检测所有受试者血清Cys-C水平。采用受试者工作特征曲线分析Hcy、Cys-C对CHF患者早期肾损伤的诊断价值。结果　CHF合并早期肾损伤组患者血清Cys-C、Hcy水平显著高于CHF组和健康对照组（P<0.05），CHF组患者血清Cys-C、Hcy水平显著高于健康对照组（P<0.05）。Cys-C、Hcy诊断CHF患者早期肾损伤的曲线下面积分别为0.815、0.743（P<0.001），敏感度分别为68.9%、82.2%，特异度分别为86.8%、64.2%。Cys-C、Hcy诊断 CHF患者早期肾损伤的的最佳临界值分别为1.35 mg·L-1、16.88 μmol·L-1。结论　血清Cys-C、Hcy水平均可作为诊断CHF患者早期肾损伤的生物标志物。
Abstract:
Objective　To explore the clinical value of serum homocysteine (Hcy) and cystatin C (Cys-C) levels in the diagnosis of early renal injury in patients with chronic heart failure (CHF).Methods　A total of 98 CHF patients admitted to the First Affiliated Hospital of Xinxiang Medical University from May 2018 to December 2019 were selected as the research subjects.The patients were divided into CHF group (n=53) and CHF combined with early renal injury group (n=45) according to the glomerular filtration rate (GFR).In addition,healthy individuals who had physical examinations during the same period were selected as the healthy control group (n=66).The serum level of Hcy of all subjects was detected by enzyme circulation method,and the serum level of Cys-C of all subjects was detected by latex enhanced immunoturbidimetry.The diagnostic value of Hcy and Cys-C in early renal injury of patients with CHF was analyzed by receiver operating characteristic curve.Results　The serum levels of Cys-C and Hcy of patients in the CHF combined with early renal injury group were significantly higher than those in the CHF group and healthy control group (P<0.05)the serum levels of Cys-C and Hcy of patients in the CHF group were significantly higher than those in healthy control group (P<0.05).The area under the curve of Cys-C and Hcy in the diagnosis of early renal injury in CHF patients were 0.815 and 0.743 (P<0.001).The sensitivity of Cys-C and Hcy in the diagnosis of early renal injury in CHF patients were 68.9% and 82.2%,and the specificity were 86.8% and 64.2%,respectively.The optimum critical values of Cys-C and Hcy in the diagnosis of early renal injury in patients with CHF were 1.35 mg· L-1 and 16.88 μmol·L-1,respectively.Conclusion　Serum levels of Cys-C and Hcy can be used as biomarkers for the diagnosis of early renal injury in patients with CHF.

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更新日期/Last Update: 2021-11-05