[1]霍晓燕,王　芳.重组人血管内皮抑制素、顺铂和氟尿嘧啶联合治疗对宫颈癌患者血清肿瘤标志物及microRNA-24和microRNA-155水平的影响[J].新乡医学院学报,2021,38(5):431-435.[doi:10.7683/xxyxyxb.2021.05.007]
　HUO Xiaoyan,WANG Fang.Effect of combination therapy of recombinant human endostatin,cisplatin and fluorouracil on the levels of serum tumor markers,microRNA-24 and microRNA-155 of patients with cervical cancer[J].Journal of Xinxiang Medical University,2021,38(5):431-435.[doi:10.7683/xxyxyxb.2021.05.007]
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重组人血管内皮抑制素、顺铂和氟尿嘧啶联合治疗对宫颈癌患者血清肿瘤标志物及microRNA-24和microRNA-155水平的影响
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
38
期数:
2021年5
页码:
431-435
栏目:
临床研究
出版日期:
2021-05-05

文章信息/Info

Title:
Effect of combination therapy of recombinant human endostatin,cisplatin and fluorouracil on the levels of serum tumor markers,microRNA-24 and microRNA-155 of patients with cervical cancer
作者:
霍晓燕1; 王　芳2
（1.邯郸市第一医院妇产科，河北　邯郸　056002；2.河北大学附属医院妇产科，河北　保定　071000）
Author(s):
HUO Xiaoyan1; WANG Fang2
(1.Department of Obstetrics and Gynecology,the First Hospital of Handan City,Handan 056002,Hebei Province,China2.Department of Obstetrics and Gynecology,the Affiliated Hospital of Hebei University,Baoding 071000,Hebei Province,China)
关键词:
宫颈癌; 重组人血管内皮抑制素; 顺铂; 氟尿嘧啶; 肿瘤标志物; microRNA-24; microRNA-155
Keywords:
cervical cancerrecombinant human endostatincisplatinfluorouraciltumor markermicroRNA-24microRNA-155
分类号:
R730
DOI:
10.7683/xxyxyxb.2021.05.007
文献标志码:
A
摘要:
目的　探讨重组人血管内皮抑制素、顺铂和氟尿嘧啶联合治疗对宫颈癌患者血清肿瘤标志物及microRNA-24（miR-24）和 microRNA-155（miR-155）水平的影响。方法　选择2017年1月至2019年1月邯郸市第一医院收治的106例宫颈癌患者为研究对象，按照治疗方法分为观察组和对照组，每组53例。2组患者均给予放射治疗和顺铂、氟尿嘧啶化学治疗，在此基础上，观察组患者给予重组人血管内皮抑制素治疗。对2组患者治疗前后血清基质金属蛋白酶-9（MMP-9）、血管内皮生长因子（VEGF）、癌胚抗原相关细胞黏附分子6（CEACAM6）、鳞状细胞癌抗原（SCCA）、糖链抗原15-3（CA15-3）、糖链抗原19-9（CA19-9）、糖链抗原125（CA125）、miR-24、miR-155水平进行比较，治疗期间观察患者不良反应发生情况，治疗后评估患者临床疗效。结果　治疗前2组患者血清SCCA、CA15-3、CA19-9、CA125、MMP-9、VEGF、CEACAM6水平比较差异无统计学意义（P＞0.05）；2组患者治疗后血清SCCA、CA15-3、CA19-9、CA125、MMP-9、VEGF、CEACAM6水平显著低于治疗前（P＜0.05）；治疗后，观察组患者血清SCCA、CA15-3、CA19-9、CA125、MMP-9、VEGF、CEACAM6水平显著低于对照组（P＜0.05）。治疗前2组患者血清中miR-24、miR-155相对表达量比较差异无统计学意义（P＞0.05）；与治疗前比较，治疗后2组患者血清中miR-24相对表达量升高，血清中miR-155相对表达量降低（P＜0.05）；治疗后，观察组患者血清中miR-24相对表达量显著高于对照组，血清中miR-155相对表达量显著低于对照组（P＜0.05）。观察组患者肿瘤缓解率为52.83%（28/53），肿瘤控制率为83.02%（44/53）；对照组患者肿瘤缓解率为32.07%（17/53），肿瘤控制率为73.58%（39/53）；观察组患者肿瘤缓解率显著高于对照组（χ2=4.673,P＜0.05），2组患者肿瘤控制率比较差异无统计学意义（χ2=1.388,P＞0.05）。2组患者呕吐恶心、血小板减少、肝功能损伤、肾功能损伤及骨髓抑制发生率比较差异无统计学意义（P＞0.05）。结论　顺铂、氟尿嘧啶和重组人血管内皮抑制素联合治疗可有效降低宫颈癌患者血清肿瘤标志物水平，抑制肿瘤生长，提高治疗效果，其机制可能与重组人血管内皮抑制素调节血清MMP-9、VEGF、CEACAM6、miR-24和miR-155水平有关。
Abstract:
Objective　To investigate the effect of combination therapy of recombinant human endostatin,cisplatin and fluorouracil on the levels of serum tumor markers,microRNA-24(miR-24) and microRNA-155(miR-155) in patients with cervical cancer.Methods　　A total of 106 patients with cervical cancer admitted to the First Hospital of Handan City from January 2017 to January 2019 were selected as the research subjects,and the patients were divided into the observation group and the control group according to the treatment method,with 53 cases in each group.The patients in the two groups were given radiotherapy and chemotherapy of cisplatin and fluorouracil,on this basis,the patients in the observation group were given recombinant human endostatin treatment.The levels of serum matrix metalloproteinase-9 (MMP-9),vascular endothelial growth factor (VEGF),carcinoembryonic antigen related cell adhesion molecule 6 (CEACAM6),squamous cell carcinoma antigen (SCCA),carbohydrate antigen 15-3 (CA15-3),carbohydrate antigen 19-9 (CA19-9),carbohydrate antigen 125 (CA125),miR-24 and miR-155 were compared between the two groups before and after treatment.The adverse reactions were observed during the treatment,and the clinical efficacy was evaluated after treatment.Results　There was no significant difference in serum SCCA,CA15-3,CA19-9,CA125,MMP-9,VEGF and CEACAM6 levels between the two groups before treatment (P>0.05).The levels of serum SCCA,CA15-3,CA19-9,CA125,MMP-9,VEGF and CEACAM6 after treatment were significantly lower than those before treatment in the two groups (P＜0.05).The levels of serum SCCA,CA15-3,CA19-9,CA125,MMP-9,VEGF and CEACAM6 in the observation group were significantly lower than those in the control group after treatment (P＜0.05).There was no significant difference in the relative expression of serum miR-24 and miR-155 between the two groups before treatment (P>0.05).Compared with the pretreatment,the relative expression of serum miR-24 increased and the relative expression of miR-155 decreased after treatment in the two groups (P＜0.05).After treatment,the relative expression of serum miR-24 in the observation group was significantly higher than that in the control group,and the relative expression of serum miR-155 in the observation group was significantly lower than that in the control group (P＜0.05).The tumor remission rate was 52.83% (28/53),and the tumor control rate was 83.02% (44/53) in the observation group;the tumor remission rate was 32.07% (17/53),and the tumor control rate was 73.58% (39/53) in the control group.The tumor remission rate in the observation group was significantly higher than that in the control group (χ2=4.673,P＜0.05),but there was no significant difference in the tumor control rate between the two groups (χ2=1.388，P>0.05).Conclusion　The combination therapy of cisplatin,fluorouracil and recombinant human endostatin can effectively reduce the serum tumor marker levels,inhibit tumor growth and improve the therapeutic effect of patients with cervical cancer.The mechanism may be related to the regulation of serum MMP-9,VEGF,CEACAM6,miR-24 and miR-155 levels by recombinant human endostatin.

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更新日期/Last Update: 2021-05-05