[1]管丽红,贾紫森,林俊堂.规律成簇间隔短回文重复-相关核酸内切酶9技术在基因组编辑和基因转录调控中的应用[J].新乡医学院学报,2021,(1):001-5.[doi:10.7683/xxyxyxb.2021.01.001]
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规律成簇间隔短回文重复-相关核酸内切酶9技术在基因组编辑和基因转录调控中的应用
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
期数:
2021年1
页码:
001-5
栏目:
专家论坛
出版日期:
2021-01-05

文章信息/Info

作者:
管丽红12贾紫森12林俊堂123
(1.新乡医学院生命科学技术学院,河南省干细胞医学国际联合实验室,河南省干细胞与生物治疗技术研究中心,河南 新乡 453003;2.河南省医用组织再生重点实验室,河南 新乡 453003;3.新乡医学院医学工程学院,河南 新乡 453003)
关键词:
CRISPR-Cas9技术基因敲除基因治疗CRISPR干扰CRISPR激活
分类号:
Q789
DOI:
10.7683/xxyxyxb.2021.01.001
文献标志码:
A
摘要:
规律成簇间隔短回文重复(CRISPR)及CRISPR相关核酸内切酶(Cas)系统是古生菌和细菌中一类重要的获得性免疫系统,可有效抵御噬菌体等外源遗传物质的侵袭、感染。近年来,CRISPR-Cas9系统被发展为一种由RNA指导核酸内切酶的基因编辑技术。本文就该技术在基因组编辑及基因转录调控中的应用进行综述。

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更新日期/Last Update: 2021-01-05