[1]王 亚,王二辉,刘庆真,等.臭氧诱发神经系统损伤研究进展[J].新乡医学院学报,2020,37(11):1097-1100.[doi:10.7683/xxyxyxb.2020.11.021.]
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臭氧诱发神经系统损伤研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
37
期数:
2020年11
页码:
1097-1100
栏目:
综述
出版日期:
2020-11-05

文章信息/Info

作者:
王 亚王二辉刘庆真吴卫东
(新乡医学院公共卫生学院,河南 新乡 453003)
关键词:
臭氧空气污染中枢神经系统炎症反应氧化应激
分类号:
R994.6
DOI:
10.7683/xxyxyxb.2020.11.021.
文献标志码:
A
摘要:
近年来,我国针对以大气细颗粒物(PM2.5)为主的雾霾污染治理已初见成效,然而二次污染物臭氧(O3)的浓度还在不断升高。O3具有强氧化性和刺激性,急、慢性O3暴露可损伤人体各系统,引起心血管系统和呼吸系统疾病发病率、住院率及病死率上升;也可直接损伤中枢神经系统,或通过呼吸和免疫系统释放有害因子,经过血液循环到达大脑,间接引起大脑神经炎症和氧化应激等反应,最终引起神经退行性病变,如阿尔茨海默症、帕金森病和老年痴呆等。O3对神经系统损伤的机制尚未完全阐明,推测与血脑屏障通透性改变、神经炎症、氧化应激、病理性蛋白聚集和神经元异常凋亡有关。本文就近年来O3对神经系统的损伤及其机制的主要研究进展进行综述,以期为相关研究提供线索。

参考文献/References:

[1] SHAO M,ZHANG Y,ZENG L,et al.Ground-level ozone in the pearl river delta and the roles of VOC and NO(x) in its production[J].J Environ Manage,2009,90(1):512-518.
[2] LI K,JACOB D J,LIAO H,et al.Anthropogenic drivers of 2013-2017 trends in summer surface ozone in China[J].Proc Natl Acad Sci U S A,2019,116 (2):422-427.
[3] LIU Q,LIU T,CHEN Y,et al.Effects of aerosols on the surface ozone generation via a study of the interaction of ozone and its precursors during the summer in Shanghai,China[J].Sci Total Environ,2019,675:235-246.
[4] SREBOT V,GIANICOLO E A,RAINALDI G,et al.Ozone and cardiovascular injury[J].Cardiovasc Ultrasound,2009,7:30.
[5] 王璐,周新,魏永杰,等.臭氧对气道疾病的影响及机制研究进展[J].国际呼吸杂志,2018,38(5):387-391.
[6] ARJOMANDI M,WONG H,DONDE A,et al.Exposure to medium and high ambient levels of ozone causes adverse systemic infla-mmatory and cardiac autonomic effects[J].Am J Physiol Heart Circ Physiol,2015,308(12):H1499-H1509.
[7] CHEN C H,CHAN C C,CHEN B Y,et al.Effects of particulate air pollution and ozone on lung function in non-asthmatic children[J].Environ Res,2015,137:40-48.
[8] FRAMPTON M W,PIETROPAOLI A,DENTLER M,et al.Cardiovascular effects of ozone in healthy subjects with and without deletion of glutathione-S-transferase M1[J].Inhal Toxicol,2015,27(2):113-119.
[9] SERMIN G,ZEYNEP Z,FUSS S H,et al.The adverse effects of air pollution on the nervous system[J].J Toxicol,2012,2012:782462.
[10] CHEN H,GOLDBERG M S,VILLENEUVE P J.A Systematic review of the relation between long-term exposure to ambient air pollution and chronic diseases[J].Rev Environ Health,2008,23(4):243-297.
[11] OBERDRSTER G,UTELL M J.Ultrafine particles in the urban air:to the respiratory tract--and beyond[J].Environ Health Perspect,2002,110(8):A440-A441.
[12] CROZE M L,ZIMMER L,LEE H G.Ozone atmospheric pollution and alzheimer′s disease:from epidemiological facts to molecular mechanisms[J].J Alzheimers Dis,2018,62(2):503-522.
[13] KIRRANE E F,BOWMAN C,DAVIS J A,et al.Associations of ozone and PM2.5 concentrations with parkinson′s disease among participants in the agricultural health study[J].J Occup Environ Med,2015,57(5):509 -517.
[14] THOMSON E M.Air pollution,stress,and allostatic load:linking systemic and central nervous system impacts[J].J Alzheimers Dis,2019,69(Suppl 1):1-18.
[15] MARTNEZ-LAZCANO J C,GONZLEZ-GUEVARA E,DEL CARMEN RUBIO M ,et al.The effects of ozone exposure and associated injury mechanisms on the central nervous system[J].Rev Neurosci,2013,24(3):337-352.
[16] RIVAS-ARANCIBIA S,GUEVARA-GUZMN R,LO'PEZ-VIDAL Y,et al.Oxidative stress caused by ozone exposure induces loss of brain repair in the hippocampus of adult rats[J].Toxicol Sci,2010,113(1):187-197.
[17] BLOCK M L,CALDERO'N-GARCIDUEN~AS L.Air pollution:mechanisms of neuroinflammation and CNS disease[J].Trends Neurosci,2009,32(9):506-516.
[18] CALDERO'N-GARCIDUEN~AS L,LERAY E,HEYDARPOUR P,et al.Air pollution,a rising environmental risk factor for cognition,neuroinflammation and neurodegeneration:the clinical impact on children and beyond[J].Rev Neurol (Paris),2016,172(1):69-80.
[19] JUNG C R,LIN Y T,HWANG B F.Ozone,particulate matter,and newly diagnosed alzheimer′s disease:a population-based cohort study in Taiwan[J].J Alzheimers Dis,2015,44(2):573-584.
[20] CLEARY E G,CIFUENTES M,GRINSTEIN G,et al.Association of low-level ozone with cognitive decline in older adults[J].J Alzheimers Dis,2018,61(1):67-78 .
[21] CHEN H,KWONG J C,COPES R,et al.Exposure to ambient air pollution and the incidence of dementia:a population-based cohort study[J].Environ Int,2017,108:271-277.
[22] CALDERO'N-GARCIDUEN~AS L,AZZARELLI B,ACUNA H,et al.Air pollution and brain damage[J].Toxicol Pathol,2002,30(3):373-389.
[23] CALDERO'N-GARCIDUEN~AS L,REED W,MARONPOT R R,et al.Brain inflammation and Alzheimer′s-like pathology in indivi-duals exposed to severe air pollution[J].Toxicol Pathol,2004,32 (6):650-658.
[24] CALDERO'N-GARCIDUEN~AS L,KAVANAUGH M,BLOCK M,et al.Neuroinflammation,hyperphosphorylated tau,diffuse amyloid plaques,and down-regulation of the cellular prion protein in air pollution exposed children and young adults[J].J Alzheimers Dis,2012,28(1):93-107.
[25] TYLER C R,NOOR S,YOUNG T,et al.Aging exacerbates neuroinflammatory outcomes induced by acute ozone exposure[J].Toxicol Sci,2018,163(1):123-139.
[26] AKHTER H,BALLINGER C,LIU N,et al.Cyclic ozone exposure induces gender-dependent neuropathology and memory decline in an animal model of alzheimer′s disease[J].Toxicol Sci,2015,147(1):222-234 .
[27] GO'MEZ-CRISO'STOMO N P,RODRGUEZ MARTNEZ E,RIVAS-ARANCIBIA S.Oxidative stress activates the transcription factors FoxO 1a and FoxO 3a in the hippocampus of rats exposed to low doses of ozone[J].Oxid Med Cell Longev,2014,2014:805764.
[28] DORADO-MARTNEZ C,PAREDES-CARBAJAL C,MASCHER D,et al.Effects of different ozone doses on memory,motor activity and lipid peroxidation levels,in rats[J].Int J Neurosci,2001,108(3-4):149-161 .
[29] HADDAD-TO'VOLLI R,DRAGANO N R V,RAMALHO A F S,et al.Development and function of the blood-brain barrier in the context of metabolic control[J].Front Neurosci,2017,11:224.
[30] ABBOTT N J,FRIEDMAN A.Overview and introduction:the blood-brain barrier in health and disease[J].Epilepsia,2012,53 Suppl 6(6):1-6.
[31] ARJOMANDI M,WONG H,DONDE A,et al.Exposure to medium and high ambient levels of ozone causes adverse systemic inflammatory and cardiac autonomic effects[J].Am J Physiol Heart Circ Physiol,2015,308(12):H1499-H1509.
[32] RIVAS-ARANCIBIA S,VAZQUEZ-SANDOVAL R,GONZALEZ-KLADIANO D,et al.Effects of ozone exposure in rats on memory and levels of brain and pulmonary superoxide dismutase[J].Environ Res,1998,76(1):33-39.
[33] YUAN T F,GU S,SHAN C,et al.Oxidative stress and adult neurogenesis[J].Stem Cell Rev Rep,2015,11(5):706-709.
[34] GONZLEZ-GUEVARA E,MARTNEZ-LAZCANO J C,CUSTODIO V,et al.Exposure to ozone induces a systemic inflammatory response:possible source of the neurological alterations induced by this gas[J].Inhal Toxicol,2014,26(8):485-491.
[35] CUNNINGHAM C,CAMPION S,LUNNON K,et al.systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease[J].Bio Psychiatry,2009,65(4):304-312.
[36] HERNNDEZ-ZIMBRO'N L F,RIVAS-ARANCIBIA S.Oxidative stress caused by ozone exposure induces β-amyloid 1-42 overproduction and mitochondrial accumulation by activating the amyloidogenic pathway[J].Neuroscience,2015,304:340-348.
[37] HERNNDEZ-ZIMBRO'N L F,RIVAS-ARANCIBIA S.Syntaxin 5 overexpression andβ-amyloid 1-42 accumulation in endoplasmic reticulum of hippocampal cells in rat brain induced by ozone exposure[J].Biomed Res Int,2016,2016:2125643.
[38] RIVAS-ARANCIBIA S,ZIMBRO'N L F,RODRGUEZ-MARTNEZ E,et al.Oxidative stress-dependent changes in immune responses and cell death in the substantia nigra after ozone exposure in rat[J].Front Aging Neurosci,2015,7:65.
[39] GUILLOT-SESTIER M V,TOWN T.Innate immunity in Alzheimer′s disease:a complex affair[J].CNS Neurol Disord Drug Targets,2013,12(5):593-607.
[40] HICKMAN S E,ALLISON E K,KHOURY J E.Microglial dysfunction and defective β-amyloid clearance pathways in aging alzheimer′s disease mice[J].J Neurosci,2008,28(33):8354-8360
[41] ALAVI NAINI S M,SOUSSI-YANICOSTAS N.Tau hyperphosphorylation and oxidative stress,a critical vicious circle in neurodegenerative tauopathies[J].Oxid Med Cell Longev,2015,2015:151979.
[42] SULTANA R,BOYD-KIMBALL D,POON H F,et al.Oxidative modification and down-regulation of pin1 in alzheimer′s disease hippocampus:a redox proteomics analysis[J].Neurobiol Aging,2006,27(7):918-925.
[43] GLASS C K,SAIJO K,WINNER B,et al.Mechanisms underlying Inflammation in neurodegeneration[J].Cell,2010,140(6):918-934.
[44] BALLATORE C,LEE M Y,TROJANOWSKI J Q.Tau-mediated neurodegeneration in Alzheimer′s disease and related disorders[J].Nat Rev Neurosci,2007,8(9):663-672.
[45] ELMORE S.Apoptosis:a review of programmed cell death[J].Toxicol Pathol,2007,35(4):495-516.
[46] OTT M,GOGVADZE V,ORRENIUS S,et al.Mitochondria,oxidative stress and cell death[J].Apoptosis,2007,12(5):913-922.
[47] FISCHER R,MAIER O.Interrelation of oxidative stress and inflammation in neurodegenerative disease:role of TNF[J].Oxid Med Cell Longev,2015,2015:610813.
[48] KAYED R,LASAGNA-REEVES C A.Molecular mechanisms of amyloid oligomers toxicity[J].J Alzheimers Dis,2013,33 (Suppl 1):S67-S78.

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更新日期/Last Update: 2020-11-05