[1]唐灿伟,陈清江,陈菲,等.基于数据库分析脂肪非典型钙黏蛋白1在肝细胞癌中的表达及其临床意义[J].新乡医学院学报,2020,37(10):925-929.[doi:10.7683/xxyxyxb.2020.10.006]
　TANG Canwei,CHEN Qingjiang,CHEN Fei,et al.Expression and clinical significance of adipose atypical cadherin 1 in hepatocellular carcinoma based on database[J].Journal of Xinxiang Medical University,2020,37(10):925-929.[doi:10.7683/xxyxyxb.2020.10.006]
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基于数据库分析脂肪非典型钙黏蛋白1在肝细胞癌中的表达及其临床意义
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
37
期数:
2020年10
页码:
925-929
栏目:
临床研究
出版日期:
2020-10-05

文章信息/Info

Title:
Expression and clinical significance of adipose atypical cadherin 1 in hepatocellular carcinoma based on database
作者:
唐灿伟1; 陈清江2; 陈菲3; 张旭东4; 陈国荣1; 杨万秋1; 王进隆1; 薛伍君1; 吴晓爽1; 吴少璇4; 尹美凤4; 胡俊霞4; 王欣4; 候户婷4; 钱思宇4
(1.新乡医学院第三附属医院肿瘤科，河南　新乡　453003；2.新乡医学院，河南　新乡　453003；3.南昌大学玛丽女王学院，江西　南昌　330000；4.郑州大学第一附属医院肿瘤科，河南 　郑州　450052）
Author(s):
TANG Canwei1; CHEN Qingjiang2; CHEN Fei3; ZHANG Xudong1; CHEN Guorong1; YANG Wanqiu1; WANG Jinlong1; XUE Wujun1; WU Xiaoshuang1; WU Shaoxuan4; YIN Meifeng4; HU Junxia4; WANG Xin4; HOU Huting4; QIAN Siyu4
(1.Department of Oncology,the Third Affiliated Hospital of Xinxiang Medical University，Xinxiang 453003,Henan Province,China;2.Xinxiang Medical University，Xinxiang 453003,Henan Province，China;3.Queen Mary College of Nanchang University,Nanchang 330000,Jiangxi Province,China;4.Department of Oncology,the First Affiliated Hospital of Zhengzhou University，Zhengzhou 450052,Henan Province，China)
关键词:
肝细胞癌; 脂肪非典型钙黏蛋白1; 基因; 预后
Keywords:
hepatocellular carcinoma; adipose atypical cadherin 1; gene; prognosis
分类号:
R735.7
DOI:
10.7683/xxyxyxb.2020.10.006
文献标志码:
A
摘要:
目的　基于Oncomine数据库和基因表达谱数据动态分析（GEPIA）数据库数据挖掘，探讨脂肪非典型钙黏蛋白1（FAT1）在肝细胞癌（HCC）中的表达水平。方法　从Oncomine数据库筛选关于不同类型肿瘤中FAT1表达的研究数据，对关于HCC多组研究数据集进行荟萃分析，分析FAT1在不同数据集中的表达情况；从GEPIA数据库下载关于HCC组织FAT1表达的研究数据，以及HCC预后和基因分析信息，分析HCC组织与正常肝组织中FAT1的差异表达，Log-rank检验分析FAT1 mRNA与HCC患者生存期的相关性；应用STRING数据库分析FAT1相互作用的蛋白网络。结果　Oncomine数据库共收录463项关于FAT1在不同类型肿瘤的研究，有统计学意义35项，其中FAT1表达水平明显增高28项，FAT1表达水平明显降低7项。涉及HCC共5项研究，其中包括5个数据集、769个样本，5项研究中FAT1均呈高表达。FAT1在HCC组织中的表达水平显著高于正常组织（P<0.05）。从GEPIA数据库筛选419例样本，其中HCC组织369例，正常肝组织50例，在HCC组织中FAT1表达水平显著高于正常组织（P<0.05）。HCC患者FAT1表达水平与总生存率和无病生存率无相关性（P>0.05）。与FAT1相互作用的蛋白有过氧化物酶体增殖物激活受体A重组蛋白、V-REL网状内皮增生病毒癌基因同源物A重组蛋白、特异性蛋白1、JUN、核因子-κB抑制剂α、原癌基因蛋白、肿瘤坏死因子、类视黄醇X受体A、一氧化氮合酶、COUP转录因子1等。结论　FAT1在HCC组织中呈高表达，但其表达水平与HCC患者的预后无相关性。
Abstract:
Objective　To explore the expression of adipose atypical cadherin 1(FAT1) in hepatocellular carcinoma (HCC) by analyzing the relevant data from the Oncomine database and Gene Expression Profiling Interactive Analysis(GEPIA) database.Methods　The research data on the expression of FAT1 in different type of cancer were screened from the Oncomine database，and the expression of FAT1 in different data sets was analyzed by the meta-analysis of multiple research data sets on HCC.The study data about the expression of FAT1 in HCC tissues and the information of prognosis and gene analysis of HCC from the GEPIA database were downloaded，the differential expression of FAT1 between HCC tissues and normal liver tissues was analyzed，and the relationship between FAT1 mRNA and HCC patients′ survival was analyzed by using Log-rank test;the protein network interacting with FAT1 were analyzed through the STRING database.Results　A total of 463 studies about FAT1 in different types of cancer were collected form the Oncomine database，of which 35 projects had statistical significance，including 28 projects with significantly increased expression of FAT1 and 7 projects with significantly decreased expression of FAT1.There was 5 projects of HCC studies，including 5 data sets and 769 samples,and the FAT1 expression were all higher in the 5 projects.The expression levels of FAT1 in HCC tissue were significantly higher than that in normal tissue (P<0.05).Four hundreds and nineteen samples were selected from the GEPIA database，including 369 cases of HCC and 50 cases of normal liver tissue,and the expression of FAT1 in HCC tissue was significantly higher than that in normal tissue (P<0.05).There was no correlation of FAT1 with the overall survival rate and disease-free survival rate in HCC patients (P>0.05).The proteins interacting with FAT1 included recombinant peroxisome proliferator activated receptor Alpha,recombinant V-REL reticuloendotheliosis viral oncogene homolog A，specific protein 1,JUN，NF-kappa-B inhibitor alpha，proto-oncogene protein，tumor necrosis factor，retinoid X receptor alpha，nitric oxide synthase，COUP transcription factor 1,and so on.Conclusion　The expression of FAT1 increased in HCC tissues，and it is not correlated with the prognosis of patients with HCC.

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更新日期/Last Update: 2022-03-15