[1]刘彦礼,曹毓琳,林俊堂.经血源子宫内膜干细胞生物学特性及临床应用研究进展[J].新乡医学院学报,2020,37(9):885-889.[doi:10.7683/xxyxyxb.2020.09.019]
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经血源子宫内膜干细胞生物学特性及临床应用研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
37
期数:
2020年9
页码:
885-889
栏目:
综述
出版日期:
2020-09-05

文章信息/Info

作者:
刘彦礼1; 2; 曹毓琳3; 林俊堂1
（1.新乡医学院干细胞与生物治疗技术研究中心，河南　新乡　453003；2.新乡市高新区中源干细胞研究院，河南　新乡　453003；3.北京臻溪谷医学研究中心，北京　100034）
关键词:
间充质干细胞; 经血源子宫内膜干细胞; 干细胞治疗; 临床应用
分类号:
R575
DOI:
10.7683/xxyxyxb.2020.09.019
文献标志码:
A
摘要:
尽管药物和外科手术在疾病治疗领域取得了重大进展，但对某些疾病（如糖尿病、关节炎及卵巢早衰等）临床仍然缺乏有效的改善与治疗。大量基础和临床试验研究已证实，间充质干细胞（MSCs）移植对上述难治性疾病具有良好的改善效果，从骨髓、脐带和脂肪组织中分离获得的MSCs是移植的主要候选细胞，但其来源受限。近年来，经血源子宫内膜干细胞（MenSCs）因其无创伤的样本采集方式、同一供体可多次采集、可获得大量遗传背景一致的种子细胞及自体移植等方面的优势，逐渐成为干细胞疗法中重要的细胞来源，并已在相关疾病的治疗中展示出良好的治疗效果。因此，本文在明确MenSCs生物学特性的基础上，对临床应用MenSCs改善相关疾病的研究进展进行总结，并结合现有基础及临床研究结果，对MenSCs移植后改善疾病的机制进行探讨。

参考文献/References:

［1］　SNEDDON J B，TANG Q，STOCK P，et al.Stem cell therapies for treating diabetes：progress and remaining challenges［J］.Cell Stem Cell，2018，22(6)：810-823.
［2］　SMOLEN J S，ALETAHA D，MCINNES I B.Rheumatoid arthritis［J］.Lancet，2016，388(10055)：2023-2038.
［3］　GOSWAMI D，CONWAY G S.Premature ovarian failure［J］.Hum Reprod Update，2005，11(4)：391-410.
［4］　DE LUCA M，AIUTI A，COSSU G，et al.Advances in stem cell research and therapeutic development［J］.Nat Cell Biol，2019，21(7)：801-811.
［5］　RIKHTEGAR R，PEZESHKIAN M，DOLATI S，et al.Stem cells as therapy for heart disease：iPSCs，ESCs，CSCs，and skeletal myoblasts［J］.Biomed Pharmacother，2019，109：304-313.
［6］　LI W，MA N，ONG L L，et al.Bcl-2 engineered MSCs inhibited apoptosis and improved heart function［J］.Stem Cells，2007，25(8)：2118-2127.
［7］　MUNDRA V，GERLING I C，MAHATO R I.Mesenchymal stem cell-based therapy［J］.Mol Pharm，2013，10(1)：77-89.
［8］　FU X，LIU G，HALIM A，et al.Mesenchymal stem cell migration and tissue repair［J］.Cells，2019，8(8)：784.
［9］　MENDT M，REZBANI K，SHPALL E.Mesenchymal stem cellderived exosomes for clinical use［J］.Bone Marrow Transplant，2019，54(Suppl 2)：789-792.
［10］　GARGETT C E，SCHWAB K E，DEANE J A.Endometrial stem/progenitor cells：the first 10 years［J］.Hum Reprod Update，2016，22(2)：137-163.
［11］　LIU Y，NIU R，YANG F，et al.Biological characteristics of human menstrual blood-derived endometrial stem cells［J］.J Cell Mol Med，2018，22(3)：1627-1639.
［12］　CHEN L，QU J，XIANG C.The multi-functional roles of menstrual blood-derived stem cells in regenerative medicine［J］.Stem Cell Res Ther，2019，10(1)：1.
［13］　PERON J P S，JAZEDJE T，BRANDAO W N，et al.Human endometrial-derived mesenchymal stem cells suppress inflammation in the central nervous system of EAE mice［J］.Stem Cell Rev Rep，2012，8(3)：940-952.
［14］　MURPHY M P，WANG H，PATEL A N，et al.Allogeneic endometrial regenerative cells：an"off the shelf solution" for critical limb ischemia［J］.J Transl Med，2008，6：45.
［15］　XIANG B，CHEN L，WANG X，et al.Transplantation of menstrual blood-derived mesenchymal stem cells promotes the repair of LPS-induced acute lung injury［J］.Int J Mol Sci，2017，18(4)：689.
［16］　FATHI-KAZEROONI M，TAVOOSIDANA G，TAGHIZADEH-JAHED M，et al.Comparative restoration of acute liver failure by menstrual blood stem cells compared with bone marrow stem cells in mice model［J］.Cytotherapy，2017，19(12)：1474-1490.
［17］　GARGETT C E.Uterine stem cells：what is the evidence［J］.Hum Reprod Update，2007，13(1):87-101.
［18］　CHAN R W，SCHWAB K E，GARGETT C E.Clonogenicity of human endometrial epithelial and stromal cells［J］.Biol Reprod，2004，70(6)：1738-1750.
［19］　MENG X，ICHIM T E，ZHONG J，et al.Endometrial regenerative cells：a novel stem cell population［J］.J Transl Med，2007，5(1)：57-66.
［20］　SUN Y，REN Y，YANG F，et al.High-yield isolation of menstrual blood-derived endometrial stem cells by direct red blood cell lysis treatment［J］.Biol Open，2019，8(5)：bio038885.
［21］　MASUDA H，MARUYAMA T，HIRATSU E，et al.Noninvasive and real-time assessment of reconstructed functional human endometrium in NOD/SCID/gamma c (null) immunodeficient mice［J］.PNAS，2007，104(6)：1925-1930.
［22］　MASUDA H，ANWAR S S，BUHRING H J，et al.A novel marker of human endometrial mesenchymal stem-like cells［J］.Cell Transplant，2012，21(10)：2201-2214.
［23］　LV H，HU Y，CUI Z，et al.Human menstrual blood：a renewable and sustainable source of stem cells for regenerative medicine［J］.Stem Cell Res Ther，2018，9(1)：325.
［24］　PATEL A N，PARK E，KUZMAN M，et al.Multipotent menstrual blood stromal stem cells：isolation，characterization，and differen-tiation［J］.Cell Transplant，2008，17(3)：303-311.
［25］　MASUDA H，MATSUZAKI Y，HIRATSU E，et al.Stem cell-like properties of the endometrial side population：implication in endometrial regeneration［J］.PLoS One，2010，5(4)：e10387.
［26］　ALLICKSON J G，SANCHEZ A，YEFIMENKO N，et al.Recent studies assessing the proliferative capability of a novel adult stem cell identified in menstrual blood［J］.Open Stem Cell J，2011，3(2011)：4-10.
［27］　KHANJANI S，KHANMOHAMMADI M，ZARNANI A H，et al.Comparative evaluation of differentiation potential of menstrual blood-versus bone marrow-derived stem cells into hepatocyte-like cells［J］.PloS One，2014，9(2)：e86075.
［28］　BORLONGAN C V，KANEKO Y，MAKI M，et al.Menstrual blood cells display stem cell-like phenotypic markers and exert neuroprotection following transplantation in experimental stroke［J］.Stem Cells Dev，2010，19(4)：439-452.
［29］　DARZI S，ZARNANI A H，JEDDI-TEHRANI M，et al.Osteogenic differentiation of stem cells derived from menstrual blood versus bone marrow in the presence of human platelet releasate［J］.Tissue Eng Part A，2012，18(15/16)：1720-1728.
［30］　HIDA N，NISHIYAMA N，MIYOSHI S，et al.Novel cardiac precursor-like cells from human menstrual blood-derived mesenchymal cells［J］.Stem Cells，2008，26(7):1695-1704.
［31］　CUI C H，UYAMA T，MIYADO K，et al.Menstrual blood-derived cells confer human dystrophin expression in the murine model of duchenne muscular dystrophy via cell fusion and myogenic transdifferentiation［J］.Mol Biol Cell，2007，18(5)：1586-1594.
［32］　ZHENG S X，WANG J，WANG X L，et al.Feasibility analysis of treating severe intrauterine adhesions by transplanting menstrual blood-derived stem cells［J］.Int J Mol Med，2018，41(4)：2201-2212.
［33］　BAGNO L，HATZISTERGOS K E，BALKAN W，et al.Mesenchymal stem cell-based therapy for cardiovascular disease：progress and challenges［J］.Mol Ther，2018，26(7)：1610-1623.
［34］　BOCKERIA L，BOGIN V，BOCKERIA O，et al.Endometrial regenerative cells for treatment of heart failure：a new stem cell enters the clinic［J］.J Transl Med，2013，11(5)：56.
［35］　LIU Y，NIU R，LI W，et al.Therapeutic potential of menstrual blood-derived endometrial stem cells in cardiac diseases［J］.Cell Mol Life Sci，2019，76(9):1681-1695.
［36］　RODRIGUES M C，GLOVER L E，WEINBREN N，et al.Toward personalized cell therapies：autologous menstrual blood cells for stroke［J］.J Biomed Biotechnol，2011，2011:194720.
［37］　WU X，LUO Y，CHEN J，et al.Transplantation of human menstrual blood progenitor cells improves hyperglycemia by promoting endogenous progenitor differentiation in type 1 diabetic mice［J］.Stem Cells Dev，2014，23(11)：1245-1257.
［38］　LV Y，XU X，ZHANG B，et al.Endometrial regenerative cells as a novel cell therapy attenuate experimental colitis in mice［J］.J Transl Med，2014，12(1)：344.
［39］　Ichim T E，Alexandrescu D T，SOLANO F，et al.Mesenchymal stem cells as anti-inflammatories：implications for treatment of Duchenne muscular dystrophy［J］.Cell Immunol，2010，260(2)：75-82.
［40］　ICHIM T E，SOLANO F，LARA F，et al.Combination stem cell therapy for heart failure［J］.Int Arch Med，2010，3(1)：5.
［41］　TAN J，LI P，WANG Q，et al.Autologous menstrual blood-derived stromal cells transplantation for severe Asherman′s syndrome［J］.Hum Reprod，2016，31(12)：2723-2729.
［42］　TERSOGLIO A E，TERSOGLIO S，SALATINO D R，et al.Regenerative therapy by endometrial mesenchymal stem cells in thin endometrium with repeated implantation failure:a novel strategy［J］.JBRA Assist Reprod，2020，24(2)：118-127.
［43］　ZAFARDOUST S，KAZEMNEJAD S，DARZI M，et al.Improvement of pregnancy rate and live birth rate in poor ovarian responders by intraovarian administration of autologous menstrual blood derived-mesenchymal stromal cells：phase I/II clinical trial［J］.Stem Cell Rev Rep，2020，16(4)：755-763.
［44］　BALSAM L B，WAGERS A J，CHRISTENSEN J L，et al.Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium［J］.Nature，2004，428(6983)：668.
［45］　JIANG Z，HU X，YU H.et al.Human endometrial stem cells confer enhanced myocardial salvage and regeneration by paracrine mechanisms［J］.J Cell Mol Med，2013，17(10)：1247-1260.
［46］　GOLPANIAN S，WOLF A，HATZISTERGOS K E，et al.Rebuilding the damaged heart：mesenchymal stem cells，cell-based therapy，and engineered heart tissue［J］.Physiol Rev，2016，96(3)：1127-1168.
［47］　CHEN L，XIANG B，WANG X，et al.Exosomes derived from human menstrual blood-derived stem cells alleviate fulminant hepatic failure［J］.Stem Cell Res Ther，2017，8(1)：9.
［48］　HU X，YU S P，FRASER J L，et al.Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis［J］.J Thorac Cardiovasc Surg，2008，135(4)：799-808.
［49］　YAN F，YAO Y，CHEN L，et al.Hypoxic preconditioning improves survival of cardiac progenitor cells：role of stromal cell derived factor-1α-CXCR4 axis［J］.PLoS One，2012，7(7)：e37948.
［50］　BUTLER J，EPSTEIN S E，GREENE S J，et al.Intravenous allogeneic mesenchymal stem cells for nonischemic cardiomyopathy：safety and efficacy results of a phase II-A randomized trial［J］.Circ Res，2017，120(2)：332-340.
［51］　SONG N，SCHOLTEMEIJER M，SHAH K.Mesenchymal stem cell immunomodulation：mechanisms and therapeutic potential［J］.Trends Pharmacol Sci，2020，41（9）：653-664.
［52］　GOMZIKOVA M O，JAMES V，RIZVANOV A A.Therapeutic application of mesenchymal stem cells derived extracellular vesicles for immunomodulation［J］.Front Immunol，2019，10：2663.
［53］　MAKRIGIANNAKIS A，KARAMOUTI M，DRAKAKIS P，et al.Fetomaternal immunotolerance［J］.Am J Reprod Immunol，2008，60(6)：482-496.

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更新日期/Last Update: 2020-09-05