参考文献/References:
［1］ COHEN A J,BRAUER M,BURNETT R,et al.Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution:an analysis of data from the Global Burden of Diseases Study 2015［J］.Lancet,2017,389(10082):1907-1918.
［2］ 索丹凤,曾三武.空气细颗粒物PM2.5对人体各系统危害的研究［J］.医学信息,2019,32(18):32-34.
［3］ 王平利,戴春雷,张成江.城市大气中颗粒物的研究现状及健康效应［J］.中国环境监测,2005,21(1):83-87.
［4］ MIYATA R,EEDEN S F V.The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particu-late matter［J］.Toxicol Appl Pharmacol,2011,257(2):209-226.
［5］ KELLY F J,FUSSELL J C.Size,source and chemical composition as determinants of toxicity attributable to ambient particulate matter［J］.Atmos Environ,2012,60:504-526.
［6］ PRAMITHA E,HARYANTO B.Effect of exposure to 2.5 μm indoor particulate matter on adult lung function in Jakarta［J］.Osong Public Health Res Perspect,2019,10(2):51-55.
［7］ GUARNIERI M,BALMES J R.Outdoor air pollution and asthma［J］.Lancet,2014,383(9928):1581-1592.
［8］ GARSHICK E.Effects of short- and long-term exposures to ambient air pollution on COPD［J］.Eur Res J,2014,44(3):558-561.
［9］ LOOMIS D,GROSSE Y,LAUBY-SECRETAN B,et al.The carcinogenicity of outdoor air pollution［J］.Lancet Oncol,2013,14(13):1262-1263.
［10］ LIU M,XUE X,ZHOU B,et al.Population susceptibility diffe-rences and effects of air pollution on cardiovascular mortality:epidemiological evidence from a time-series study［J］.Environ Sci Pollut Res Int,2019,26(16):15943-15952.
［11］ ARAUJIO J A,NEL A E.Particulate matter and atherosclerosis:role of particle size,composition and oxidative stress［J］.Part Fibre Toxicol,2009,6:24.DOI:10.1186/1743-8977-6-24.
［12］ KEEBAUGH A J,SIOUTAS C,PAKBIN P,et al.Is atherosclero-tic disease associated with organic components of ambient fine particles［J］.Sci Total Environ,2015,533:69-75.
［13］ GUXENS M,LUBCZYNSKA M J,MUETZEL R L,et al.Air pollution exposure during fetal life,brain morphology,and cognitive function in school-age children［J］.Biol Psychiatry，2018,84(4):295-303.
［14］ AGHAEI M,JANJANI H,YOUSEFIAN F,et al.Association between ambient gaseous and particulate air pollutants and attention deficit hyperactivity disorder (ADHD) in children;a systematic review［J］.Environ Res,2019,173:135-156.
［15］ CHEN X,LIU J,ZHOU J,et al.Urban particulate matter (PM) suppresses airway antibacterial defence［J］.Respir Res,2018,19(1):5.
［16］ MELODY S M,FORD J,WILLS K,et al.Maternal exposure to short-to medium-term outdoor air pollution and obstetric and neonatal outcomes:a systematic review［J］.Environ Pollut,2019,244:915-925.
［17］ KIM K J,SHIN J,CHOI J.Cancer risk from exposure to particulate matter and ozone according to obesity and health-related behaviors:a nationwide population-based cross-sectional study［J］.Cancer Epidemiol Biomarkers Prev,2019,28(2):357-362.
［18］ 陈志永,陈小岳,董慧斌,等.常州市大气细颗粒物对老年人死亡影响的时间序列研究［J］.现代预防医学,2019,46(7):1181-1185.
［19］ BELL M L,EBISU K,LEADERER B P,et al.Associations of PM2.5 constituents and sources with hospital admissions:analysis of four counties in Connecticut and Massachusetts (USA) for persons ≥ 65 years of age［J］.Environ Health Perspect,2014,122(2):138-144.
［20］ HEMMINGSEN J G,RISSLER J,LYKKESFELDT J,et al.Controlled exposure to particulate matter from urban street air is associated with decreased vasodilation and heart rate variability in overweight and older adults［J］.Part Fibre Toxicol,2015,12:6.DOI:10.1186/s12989-015-0081-9.
［21］ SARNAT S E,COULL B A,SCHWARTZ J,et al.Factors affec-ting the association between ambient concentrations and personal exposures to particles and gases［J］.Environ Health Perspect,2006,114(5):649-654.
［22］ SHIMA M.Health effects of air pollution:a historical review and present status［J］.Nihon Eiseigaku Zasshi,2017,72(3):159-165.
［23］ SCHULTZ E S,LITONJUA A A,MELEN E.Effects of long-term exposure to traffic-related air pollution on lung function in children［J］.Curr Allergy Asthma Rep,2017,17(6):41.
［24］ CHAN J K,KODANI S D,CHARRIER J G,et al.Age-specific effects on rat lung glutathione and antioxidant enzymes after inhaling ultrafine soot［J］.Am J Respir Cell Mol Biol，2013,48(1):114-124.
［25］ 余艺文,王传鹏,韩耀风,等.中国非吸烟女性肺癌危险因素的Meta分析［J］.中华流行病学杂志,2016,37(2):268-272.
［26］ 程娟.大气颗粒物污染对城区居民呼吸系统健康效应的研究［D］.武汉：华中科技大学，2016.
［27］ SU C,BREITNER S,SCHNEIDER A,et al.Short-term effects of fine particulate air pollution on cardiovascular hospital emergency room visits:a time-series study in Beijing,China［J］.Int Arch Occup Environ Health,2016,89(4):641-657.
［28］ COLAIS P,FAUSTINI A,STAFOGGIA M,et al.Particulate air pollution and hospital admissions for cardiac diseases in potentially sensitive subgroups［J］.Epidemiology,2012,23(3):473-481.
［29］ YANG I A,FONG K M,ZIMMERMAN P V,et al.Genetic susceptibility to the respiratory effects of air pollution［J］.Thorax,2008,63(6):555-563.
［30］ ADIBHESAMI G,SHAHSAVARI G R,AMIRI A,et al.Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms and lung cancer risk among a select group of Iranian people［J］.Asian Pac J Cancer Prev,2018,19(10):2921-2927.
［31］ LIANG S,WEI X,GONG C,et al.Significant association between asthma risk and the GSTM1 and GSTT1 deletion polymorphisms:an updated meta-analysis of case-control studies［J］.Respirology,2013,18(5):774-783.
［32］ BOWATTE G,LODGE C J,LOWE A J,et al.Do variants in GSTs modify the association between traffic air pollution and asthma in adolescence［J］.Int J Mol Sci,2016,17(4):485.
［33］ LI Y F,TSENG P J,LIN C C,et al.NAD(P)H:quinone oxidoreductase 1,glutathione S-transferase M1,environmental tobacco smoke exposure,and childhood asthma［J］.Mutat Res,2009,678(1):53-58.
［34］ LEVINSSON A,OLIN A C,MODIG L,et al.Interaction effects of long-term air pollution exposure and variants in the GSTP1,GSTT1 and GSTCD genes on risk of acute myocardial infarction and hypertension:a case-control study［J］.PLoS One,2014,9(6):e99043.
［35］ JI H,KHURANA HERSHEY G K.Genetic and epigenetic influence on the response to environmental particulate matter［J］.J Allergy Clin Immunol,2012,129(1):33-41.
［36］ LAWAL A,ZHANG M,DITTMAR M,et al.Heme oxygenase-1 protects endothelial cells from the toxicity of air pollutant chemicals［J］.Toxicol Appl Pharmacol,2015,284(3):281-291.
［37］ BARRIER M,BEGORRE M A,BAUDRIMONT I,et al.Involvement of heme oxygenase-1 in particulate matter-induced impairment of NO-dependent relaxation in rat intralobar pulmonary arteries［J］.Toxicol In Vitro,2016,32:205-211.
［38］ XU X,YAVAR Z,VERDIN M,et al.Effect of early particulate air pollution exposure on obesity in mice:role of p47phox［J］.Arterioscler Thromb Vasc Biol,2010,30(12):2518-2527.
［39］ WEICHENTHAL S,HOPPIN J A,REEVES F.Obesity and the cardiovascular health effects of fine particulate air pollution［J］.Obesity (Silver Spring),2014,22(7):1580-1589.
［40］ MACCHI C,FERRI N,FAVERO C,et al.Long-term exposure to air pollution raises circulating levels of proprotein convertase subtilisin/kexin type 9 in obese individuals［J］.Eur J Prev Cardiol,2019,26(6):578-588.
［41］ POTT J,SCHLEGEL V,TEREN A,et al.Genetic pegulation of PCSK9 (proprotein convertase subtilisin/kexin type 9) plasma levels and its impact on atherosclerotic vascular disease phenotypes［J］.Circ Genom Precis Med,2018,11(5):e001992.
［42］ SPOSATO B,SCALESE M,MIGLIORINI M G,et al.Obesity can influence children′s and adolescents′ airway hyperresponsiveness differently［J］.Multidiscip Respir Med,2013,8(1):60.
［43］ CLARK C,SBIHI H,TAMBURUC L,et al.Association of long-term exposure to transportation noise and traffic-related air pollution with the incidence of diabetes:a prospective cohort study［J］.Environ Health Perspect,2017,125(8):087025.
［44］ KHAFAIE M A,SALVI S S,YAJNIK C S,et al.Air pollution and respiratory health among diabetic and non-diabetic subjects in Pune,India-results from the Wellcome Trust Genetic Study［J］.Environ Sci Pollut Res Int,2017,24(18):15538-15546.
［45］ AKBARZADEH M A,KHAHESHI I,SHARIFI A,et al.The association between exposure to air pollutants including PM10,PM2.5,ozone,carbon monoxide,sulfur dioxide,and nitrogen dioxide concentration and the relative risk of developing STEMI:a case-crossover design［J］.Environ Res,2018,161:299-303.
［46］ PAN K,JIANG S,DU X,et al.AMPK activation attenuates inflammatory response to reduce ambient PM2.5-induced metabolic disorders in healthy and diabetic mice［J］.Ecotoxicol Environ Saf,2019,179:290-300.
［47］ YAN Y H,C-K CHOU C,WANG J S,et al.Subchronic effects of inhaled ambient particulate matter on glucose homeostasis and target organ damage in a type 1 diabetic rat model［J］.Toxicol Appl Pharmacol,2014,281(2):211-220.