[1]夏　雪,肖　蓓,林　辉.终末期肾脏病患者血管钙化和血清骨硬化蛋白水平分析[J].新乡医学院学报,2020,37(8):758-761.[doi:10.7683/xxyxyxb.2020.08.013]
　XIA Xue,XIAO Bei,LIN Hui.Analysis of vascular calcification and serum sclerostin level in patients with end-stage renal disease[J].Journal of Xinxiang Medical University,2020,37(8):758-761.[doi:10.7683/xxyxyxb.2020.08.013]
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终末期肾脏病患者血管钙化和血清骨硬化蛋白水平分析
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
37
期数:
2020年8
页码:
758-761
栏目:
临床研究
出版日期:
2020-08-05

文章信息/Info

Title:
Analysis of vascular calcification and serum sclerostin level in patients with end-stage renal disease
作者:
夏　雪; 肖　蓓; 林　辉
（合肥市第一人民集团医院肾内科，安徽　合肥　230061）
Author(s):
XIA Xue; XIAO Bei; LIN Hui
(Department of Nephrology,the First People′s Group Hospital of Hefei,Hefei 230061,Anhui Province,China)
关键词:
终末期肾脏病; 骨硬化蛋白; 血管钙化
Keywords:
end-stage renal disease; sclerostin; vascular calcification
分类号:
R692.5
DOI:
10.7683/xxyxyxb.2020.08.013
文献标志码:
A
摘要:
目的　探讨终末期肾脏病（ESRD）患者血清骨硬化蛋白（SOST）水平与血管钙化（VC）的相关性。方法　选择2018年1月至2019年12月合肥市第一人民集团医院收治的66例ESRD患者作为ESRD组，另选择同期66例体检健康者作为对照组；采用酶联免疫吸附试验检测2组受试者血清SOST水平，应用冠状动脉CT影像进行ESRD患者VC评分；对ESRD组和对照组受试者相关临床指标进行比较，并对不同血清SOST水平ESRD患者相关临床指标进行比较；分析ESRD患者血清SOST水平与VC积分和心脏瓣膜钙化率的相关性。结果　ESRD组患者血清SOST、全段甲状旁腺激素(iPTH）、钙（Ca）、磷（P）、Ca×P、心脏瓣膜钙化发生率显著高于对照组（P<0.05），而血清白蛋白（ALB）水平显著低于对照组（P<0.05）；对照组与ESRD组受试者血清载脂蛋白α、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、镁（Mg）水平比较差异无统计学意义（P>0.05）。66例ESRD患者中，64例（96.97%）患者发生VC，其中43例（67.19%）患者为中、重度钙化。以血清SOST水平中位数（3.00 μg·L-1）为界值将ESRD患者分为SOST<3.00 μg·L-1组和SOST≥3.00 μg·L-1组，2组患者的性别、体质量指数及血清LDL-C、HDL-C、Ca×P、载脂蛋白α水平比较差异无统计学意义（P>0.05），SOST≥3.00 μg·L-1组患者的年龄、透析龄、心脏瓣膜钙化率、VC积分及血清ALB、iPTH、Ca、P、Mg水平显著高于SOST<3.00 μg·L-1组（P<0.05）。Spearman秩相关分析显示，ESRD患者血清SOST水平与VC积分和心脏瓣膜钙化率呈正相关（r=0.291、0.519，P<0.05）。结论　ESRD患者血清SOST水平升高，且血清SOST水平与ESRD患者心脏瓣膜钙化发生率及VC积分呈正相关。血清SOST有望成为反映ESRD患者骨转化水平和VC程度的新指标。
Abstract:
Objective　To investigate the correlation between serum sclerostin (SOST) and vascular calcification (VC) in patients with end-stage renal disease (ESRD).Methods　A total of 66 patients with ESRD in Hefei First People′s Group Hospital from January 2018 to December 2019 were selected as the ESRD group,and 66 healthy people were selected as the control group.The level of serum SOST was detected by enzyme-linked immunosorbent assay,and the VC score of ESRD patients was evaluated by CT images of coronary artery.The clinical indexes of the subjects in the ESRD group and the control group were compared,and the clinical indexes of the ESRD patients with different levels of serum SOST were compared.The correlation between serum SOST level and VC score and cardiac valvular calcification rate in ESRD patients was analyzed.Results　The levels of serum SOST,intact parathyroid hormone (iPTH),calcium (Ca),phosphorus (P),Ca×P and the rate of cardiac valvular calcification in the ESRD group were significantly higher than those in the control group (P<0.05);while the serum albumin (ALB) level in the ESRD group was significantly lower than that in the control group (P<0.05).There was no significant difference in the levels of serum apolipoprotein α,low-density lipoprotein cholesterol (LDL-C),high-density lipoprotein cholesferol (HDL-C) and magnesium (Mg) between the control group and the ESRD group (P>0.05).Among the 66 patients with ESRD,64 (96.97%) cases had VC,and 43 (67.19%) cases had moderate or severe VC.The patients with ESRD were divided into SOST<3.00 μg·L-1 group and SOST≥3.00 μg·L-1 group according to the median of serum SOST level (3.00 μg·L-1).There was no significant difference in the gender,body mass index and the levels of serum LDL-C,HDL-C,Ca×P and apolipoprotein α between the two groups (P>0.05).The age,dialysis age,cardiac valvular calcification rate,VC score and the levels of serum ALB,iPTH,Ca,P and Mg in the patients with SOST≥3.00 μg·L-1 were higher than those in the patients with SOST < 3.00 μg·L-1 (P<0.05).Spearman rank correlation analysis showed that serum SOST level was positively correlated with the VC score and cardiac valvular calcification rate (r=0.291,0.519;P<0.05).Conclusion　The level of serum SOST level increased in the ESRD patients,and the serum SOST level is positively correlated with the rate of cardiac valvular calcification and the VC score.The serum SOST is expected to be a new indicator of bone turnover and VC level in ESRD patients.

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更新日期/Last Update: 2020-08-05