[1]陈玲灵.孕三烯酮与左炔诺孕酮宫内节育系统辅助宫腔镜子宫内膜息肉切除术治疗子宫内膜息肉疗效比较[J].新乡医学院学报,2017,34(11):1012-1014.[doi:10.7683/xxyxyxb.2017.11.015]
　CHEN Ling-ling.Comparison of the effect between gestrinone and levonorgestrel intrauterine system in the treatment of patients with endometrial polyps after transcervical resection of polyp[J].Journal of Xinxiang Medical University,2017,34(11):1012-1014.[doi:10.7683/xxyxyxb.2017.11.015]
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孕三烯酮与左炔诺孕酮宫内节育系统辅助宫腔镜子宫内膜息肉切除术治疗子宫内膜息肉疗效比较
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
34
期数:
2017年11
页码:
1012-1014
栏目:
临床研究
出版日期:
2017-11-05

文章信息/Info

Title:
Comparison of the effect between gestrinone and levonorgestrel intrauterine system in the treatment of patients with endometrial polyps after transcervical resection of polyp
作者:
陈玲灵
（郑州市中心医院妇产科，河南　郑州　450007）
Author(s):
CHEN Ling-ling
（Department of Gynaecology and Obstetrics，Zhengzhou Central Hospital，Zhengzhou 450007，Henan Province，China）
关键词:
宫腔镜子宫内膜息肉切除术; 子宫内膜息肉; 孕三烯酮; 左炔诺孕酮宫内节育系统
Keywords:
transcervical resection of polyp; endometrial polyp; gestrinone; levonorgestrel intrauterine system
分类号:
R711
DOI:
10.7683/xxyxyxb.2017.11.015
文献标志码:
A
摘要:
目的　比较孕三烯酮与左炔诺孕酮宫内节育系统辅助宫腔镜子宫内膜息肉切除术（TCRP）治疗子宫内膜息肉的临床效果。方法　选取2014年1月至2017年1月于郑州市中心医院行TCRP的子宫内膜息肉患者225例，根据术后治疗方式将患者分为A、B、C组，每组75例。A组患者于术后第5天开始给予孕三烯酮治疗，B组患者在术后第1次月经来潮3～5 d放置左炔诺孕酮宫内节育系统，C组患者术后不做任何处理。所有患者术后随访6个月，观察3组患者的子宫内膜厚度、子宫内膜息肉复发及异常子宫出血改善情况。结果　A、B、C组患者子宫内膜息肉复发率分别为16.00%（12/75）、1.33%（1/75）、38.67%（29/75），异常子宫出血改善率分别为92.00%（69/75）、86.67%（65/75）、88.00%（66/75）；A、B组患者子宫内膜息肉复发率显著低于C组（χ2=9.700、32.667，P<0.05），B组患者子宫内膜息肉复发率显著低于A组（χ2=10.191，P<0.05）；3组患者异常子宫出血改善率比较差异均无统计学意义（χ2=1.170，P>0.05）。术前及术后1个月3组患者子宫内膜厚度比较差异均无统计学意义（P>0.05）；术后3个月，A、B组患者子宫内膜厚度显著小于C组（P<0.05），但A、B组患者子宫内膜厚度比较差异无统计学意义（P>0.05）；术后6个月，B组患者子宫内膜厚度显著小于A、C组（P<0.05），但A、C组患者子宫内膜厚度比较差异无统计学意义（P>0.05）。结论　孕三烯酮和左炔诺孕酮宫内节育系统辅助TCRP治疗子宫内膜息肉均能有效降低子宫内膜息肉复发率，抑制子宫内膜增生，且左炔诺孕酮宫内节育系统效果优于孕三烯酮。
Abstract:
Objective　To compare the clinical effect between gestrinone and levonorgestrel intrauterine system in the treatment of patients with endometrial polyps after transcervical resection of polyp（TCRP）.Methods　A total of 225 endometrial polyps patients underwent TCRP were selected from January 2014 to January 2017 in Zhengzhou Central Hospital.The patients were divided into group A，B and C according to the postoperative treatment，75 cases in each group.The patients in group A were treated with gestrinone from the fifth day after operation.The patients in the group B were treated with levonorgestrel intrauterine system at the 3-5 days of the first menstruation after operation.The patients in group C were not given any treatment after operation.All patients were followed up for 6 months.The endometrial thickness，the recurrence of endometrial polyps and the improvement of abnormal uterine bleeding of patients in the three groups were observed.Results　The recurrence rate of endometrial polyps in group A，B and C was 16.00% （12/75），1.33% （1/75） and 38.67% （29/75） respectively；the improvement rate of abnormal uterine bleeding was 92.00% （69/75），86.67% （65/75） and 88.00% （66/75） respectively.The recurrence rate of endometrial polyps in group A and B was significantly lower than that in group C （χ2=9.700，32.667；P<0.05），and the recurrence rate of endometrial polyps in group B was significantly lower than that in group A （χ2=10.191，P<0.05）.There was no significant difference in the improvement rate of abnormal uterine bleeding among the three groups （χ2=1.170，P>0.05）.There was no significant difference in endometrial thickness among the three groups before and one month after operation （P>0.05）.Three months after operation，the endometrial thickness in group A and B was significantly less than that in group C （P<0.05），but there was no significant difference in endometrial thickness between group A and B （P>0.05）.Six months after operation，the endometrium thickness in group B was significantly less than that in group A and C （P<0.05），but there was no significant difference in endometrial thickness between group A and C （P>0.05）.Conclusion　Gestrinone and levonorgestrel intrauterine system assisted TCRP for endometrial polyps can significantly reduce the recurrence rate of endometrial polyps，inhibit endometrial hyperplasia，and the effect of levonorgestrel intrauterine system is better than that of gestrinone.

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更新日期/Last Update: 2017-11-05