[1]侯轶楠,郝建华,陈小红,等.盐酸羟考酮注射液对腹腔镜胆囊切除术患者术后内脏痛和切口痛的影响[J].新乡医学院学报,2016,33(10):916-918.[doi:10.7683/xxyxyxb.2016.10.022]
　HOU Yi-nan,HAO Jian-hua,CHEN Xiao-hong,et al.Effect of oxycodone on visceral pain and incision pain of patients underwent laparoscopic cholecystectomy[J].Journal of Xinxiang Medical University,2016,33(10):916-918.[doi:10.7683/xxyxyxb.2016.10.022]
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盐酸羟考酮注射液对腹腔镜胆囊切除术患者术后内脏痛和切口痛的影响
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年10
页码:
916-918
栏目:
临床研究
出版日期:
2016-10-05

文章信息/Info

Title:
Effect of oxycodone on visceral pain and incision pain of patients underwent laparoscopic cholecystectomy
作者:
侯轶楠1; 2; 郝建华2; 陈小红2; 米卫东1
（1.中国人民解放军医学院，北京　100853；2.中国人民解放军总医院第一附属医院麻醉科，北京　100048）
Author(s):
HOU Yi-nan1; 2; HAO Jian-hua2; CHEN Xiao-hong2; MI Wei-dong1
（1.Chinese PLA Medical College,Beijing 100853,China;2.Department of Anesthesiology,the First Affiliated Hospital of Chinese PLA General Hospital,Beijing 100048,China）
关键词:
羟考酮; 舒芬太尼; 腹腔镜胆囊切除术; 内脏痛
Keywords:
oxycodone; sufentanil; laparoscopic cholecystectomy; visceral pain
分类号:
R614R657.4
DOI:
10.7683/xxyxyxb.2016.10.022
文献标志码:
A
摘要:
目的　观察盐酸羟考酮注射液对腹腔镜胆囊切除术患者术后内脏痛和切口痛的影响。方法　选取解放军总医院第一附属医院择期行腹腔镜胆囊切除术患者60例，随机分为羟考酮组和舒芬太尼组，每组30例。在切皮前羟考酮组患者静脉给予羟考酮注射液0.1 mg·kg-1，舒芬太尼组患者静脉给予舒芬太尼注射液0.1 μg·kg-1。患者手术结束时均采用罗哌卡因20 mL局部浸润伤口。分别于术后2、4、24 h采用视觉模拟评分法（VAS）评价患者切口痛及内脏痛疼痛程度，记录补救镇痛次数及不良反应发生率。结果　2组患者术后各时间点切口痛VAS评分比较差异均无统计学意义（P>0.05）；羟考酮组患者术后2、4 h内脏痛VAS评分显著低于舒芬太尼组（P<0.05），术后24 h 2组患者内脏痛VAS评分比较差异无统计学意义（P>0.05）。羟考酮组和舒芬太尼组患者术后24 h内平均补救镇痛次数分别为3.1±0.7和 3.5±0.8，2组比较差异无统计学意义（P>0.05）。羟考酮组和舒芬太尼组患者术后不良反应发生率分别为40.0%（12/30）和33.3%（10/30），2组比较差异无统计学意义（P>0.05）。结论　盐酸羟考酮可减轻腹腔镜胆囊切除术患者术后内脏痛。
Abstract:
Objective　To observe the effect of oxycodone on visceral pain and incision pain of patients underwent laparoscopic cholecystectomy.Methods　A total of 60 patients who underwent laparoscopic cholecystectomy in the First Affiliated Hospital of Chinese PLA General Hospital were selected and randomly divided into oxycodone group and sufentanyl group,with 30 patients in each group.Before incision,the patients in oxycodone group and sufentanyl group received intravenous injection oxycodone (0.1 mg·kg-1) and sufentanil(0.1μg·kg-1) respectively;at the end of surgery，the wound of patients was infiltrated with 20 mL ropivacaine.Visual analogue scale (VAS) was used to evaluate the visceral pain and incision pain of patients at 2,4 and 24 h after operation;the extra analgesia frequency and incidence of adverse effects were recorded.Results　There were no significant differences of VAS scores of incision pain of patients between the two groups at each time point after operation (P>0.05).The VAS scores of visceral pain of patients in oxycodone group were significantly lower than those in sufentanyl group at 2,4 h after operation;there were no statistic difference of VAS scores of visceral pain of patients between the two groups at 24 h after operation(P>0.05).The average extra analgesia frequency of patients in oxycodone group and sufentanyl group was 3.1±0.7 and 3.5±0.8;the incidence of adverse effects of patients in oxycodone group and sufentanyl group was 40.0%（12/30） and 33.3%（10/30）;there was no statistic difference of average extra analgesia frequency and incidence of adverse effects of patients between the two groups (P>0.05).Conclusion　Oxycodone can lighten visceral pain in patients who undergoing laparoscopic cholecystectomy.

参考文献/References:

［1］　何双亮，甘建辉，于虹.盐酸羟考酮在腹腔镜胆囊切除术后镇痛效果研究［J］.河北联合大学学报（医学版），2015,17（4）：29-32.
［2］　曹薇薇.盐酸羟考酮注射液对腹腔镜胆囊切除术患者全麻苏醒期的影响［J］.贵州医药,2015,39(10):908-910.
［3］　吴周全，邹志清，陈勇.不同剂量羟考酮对腹部手术后急性疼痛的抑制作用［J］.临床麻醉学杂志,2015,31(2):161-163.
［4］　刘英华，范志毅，金云玉，等.盐酸羟考酮注射液用于全麻苏醒期的安全性后有效性［J］.中国新药杂志,2015,24(4):427-429,446.
［5］　SEGAWA H，MOIL K，KASAI K，et al.The role of the phrenic nerves in stress response in upper abdominal surgery［J］.Anesth Analg，1996，82(6):1215-1224.
［6］　徐建国.盐酸羟考酮的药理学和临床应用［J］.临床麻醉学杂志，2014,30（5）：511-513.
［7］　许幸，吴新民，薛张纲，等.盐酸羟考酮注射液用于全麻患者大手术后镇痛的有效性和安全性：前瞻性、随机、盲法、多中心、阳性对照、临床研究［J］.中华麻醉学杂志，2013,33（3）：269-274.
［8］　颜江柱.羟考酮/对乙酰氨基酚的药理机制与临床应用进展［J］.中国新药杂志,2014,23(14):1658-1664.
［9］　胡建，许建峰，刘耿，等.不同剂量羟考酮术前用药对腹腔镜胆囊切除术后疼痛及炎症细胞因子的影响［J］.临床麻醉学杂志，2015,31（10）：941-944.
［10］　SCHULIGOI R，JOSIC M，HEINEMANN A，et al.Gastric acid-evoked c-fos messenger RNA expression in rat brainstem is signaled by capsaicin-resistant vagal afferents［J］.Gastroenterology，1998，115(3):649-660.
［11］　梁鹏，钟进才.羟考酮替换盐酸吗啡减轻阿片类药物耐药的临床研究［J］.中国癌症防治杂志，2011,3（1）：69-72.
［12］　杨正波，贾佳.羟考酮与舒芬太尼超前镇痛用于瑞芬太尼腹腔镜胆囊切除术的比较［J］.医药论坛杂志,2015,36(11):25-27.
［13］　祖翠华.腹腔镜胆囊切除术前给予帕瑞昔布钠对患者苏醒期躁动、疼痛及血流动力学的影响［J］.新乡医学院学报，2015,32（9）：884-886.

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更新日期/Last Update: 2016-10-05