[1]李曼丽,王阳洋,金白洁,等.表观遗传机制在神经系统疾病中的作用[J].新乡医学院学报,2016,33(9):822-826.[doi:10.7683/xxyxyxb.2016.09.024]
 LI Manli,WANG Yangyang,JIN Baijie,et al.Role of epigenetic mechanism in nervous system diseases[J].Journal of Xinxiang Medical University,2016,33(9):822-826.[doi:10.7683/xxyxyxb.2016.09.024]
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表观遗传机制在神经系统疾病中的作用
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年9
页码:
822-826
栏目:
综述
出版日期:
2016-08-23

文章信息/Info

Title:
Role of epigenetic mechanism in nervous system diseases
作者:
李曼丽1王阳洋2金白洁1郭美霞1孙 宁3
(1.新乡医学院三全学院生理学教研室,河南 新乡 453003;2.新乡医学院第一附属医院神经外科,河南 卫辉 453100;3.华中科技大学基础医学院神经生物学系,湖北 武汉 430030)
Author(s):
LI ManliWANG YangyangJIN BaijieGUO MeixiaSUN Ning
关键词:
表观遗传学DNA甲基化组蛋白修饰神经系统疾病
分类号:
R74
DOI:
10.7683/xxyxyxb.2016.09.024
文献标志码:
A
摘要:
表观遗传是指DNA序列不发生变化,而基因表达发生可遗传改变的现象,主要包括DNA甲基化、组蛋白修饰、染色质重塑、非编码RNA等4个主要调控机制。神经系统疾病是发生于中枢神经系统、周围神经系统、自主神经系统的以感觉、运动、意识、自主神经功能障碍为主要表现的疾病,病因复杂,是目前对人类危害最大的疾病之一。研究发现,神经系统疾病的发生、发展与表观遗传机制相关,这些研究为神经系统疾病的治疗提供了潜在靶点,具有积极意义。本文就有关表观遗传调控机制及其在神经系统疾病中作用的最新研究进展进行综述。

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更新日期/Last Update: 2016-09-05