[1]马圆真,刘亚静,徐光华,等.基质金属蛋白酶基因启动区3个单核苷酸多态性与河南汉族群体慢性心力衰竭遗传易感性关联研究[J].新乡医学院学报,2016,33(7):568-571.[doi:10.7683/xxyxyxb.2016.07.005]
　MA Yuan-zhen,LIU Ya-jing,XU Guang-hua,et al.Correlation of matrix metalloproteinases promoter region three single nucleotide polymorphisms with genetic susceptibility of chronic heart failure in Henan Han population[J].Journal of Xinxiang Medical University,2016,33(7):568-571.[doi:10.7683/xxyxyxb.2016.07.005]
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基质金属蛋白酶基因启动区3个单核苷酸多态性与河南汉族群体慢性心力衰竭遗传易感性关联研究
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年7
页码:
568-571
栏目:
基础研究
出版日期:
2016-07-05

文章信息/Info

Title:
Correlation of matrix metalloproteinases promoter region three single nucleotide polymorphisms with genetic susceptibility of chronic heart failure in Henan Han population
作者:
马圆真1; 刘亚静1; 徐光华1; 张　倩1; 王　宇1; 郭利伟2; 黄艳梅2
（1.新乡医学院，河南　新乡　453003；2.新乡医学院法医学系法医物证学教研室，河南　新乡　453003）
Author(s):
MA Yuan-zhen1; LIU Ya-jing1; XU Guang-hua1; ZHANG Qian1; WANG Yu1; GUO Li-wei2; HUANG Yan-mei2
(1.Xinxiang Medical University,Xinxiang 453003,Henan Province,China;2.Department of Forensic Genetics，Xinxiang Medical University，Xinxiang 453003，Henan Province，China)
关键词:
基质金属蛋白酶; 慢性心力衰竭; 单核苷酸多态性; 限制性扩增片段长度多态性
Keywords:
matrix metalloproteinases; chronic heart failure; single nucleotide polymorphism; polymerase chain reaction restriction fragment length polymorphism
分类号:
R541.6
DOI:
10.7683/xxyxyxb.2016.07.005
文献标志码:
A
摘要:
目的　探讨基质金属蛋白酶（MMPs）基因启动区rs1799750、rs3025058及rs227610单核苷酸多态性（SNP）与河南汉族群体慢性心力衰竭(CHF)发病风险的相关性。方法　采用限制性扩增片段长度多态性（PCR-RFLP）方法检测124例CHF患者（CHF组）和144名健康者（对照组）的3个SNP，运用SHEsis软件分析数据。结果　CHF组rs1799750的1G等位基因频率较对照组显著降低（P<0.01），1G1G基因型频率也较对照组显著降低（P<0.01）。CHF组1G6A单体型的频率显著低于对照组（P<0.01）。结论　河南汉族群体中rs1799750 位点1G等位基因和单体型1G6A可能会降低个体CHF的患病风险。
Abstract:
Objective　To investigate the relationship between single nucleotide polymorphism (SNP) of rs1799750，rs3025058 and rs227610 at the promoter region of matrix metalloproteinases（MMPs） genes and onset risk of chronic heart failure (CHF) in Henan Han population.Methods　Three SNP sites of 124 CHF patients(CHF group) and 144 normal people(control group) were detected by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).And the data was analyzed by SHEsis soft.Results　The frequency of 1G allele and 1G1G genotype of rs1799750 of patients in the CHF group was significantly lower than that in the control group（P<0.01）.The frequency of 1G6A haplotype of patients in CHF group was significantly lower than that in the control group （P<0.01）.Conclusion　1G allele of rs1799750 and haplotype 1G6A may decrease the onset risk of CHF.

参考文献/References:

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更新日期/Last Update: 2016-07-05