[1]成瑞博,邱亚峰,王　娟.奥氮平与阿立哌唑对首发精神分裂症患者神经认知功能损害的治疗效果比较[J].新乡医学院学报,2016,33(2):116-119.[doi:10.7683/xxyxyxb.2016.02.009]
　CHENG Rui-bo,QIU Ya-feng,WANG Juan.Clinical efficacy of aripiprazole and olanzapine on the neurocognitive function in patients with first-episode schizophrenia[J].Journal of Xinxiang Medical University,2016,33(2):116-119.[doi:10.7683/xxyxyxb.2016.02.009]
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奥氮平与阿立哌唑对首发精神分裂症患者神经认知功能损害的治疗效果比较
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年2
页码:
116-119
栏目:
临床研究
出版日期:
2016-02-05

文章信息/Info

Title:
Clinical efficacy of aripiprazole and olanzapine on the neurocognitive function in patients with first-episode schizophrenia
作者:
成瑞博1; 邱亚峰2; 王　娟3
（1.新乡医学院，河南　新乡　453003;2.新乡医学院研究生培养基地南阳市精神病医院，河南　南阳　473000；3.新乡医学院第二附属医院，河南　新乡　453000）
Author(s):
CHENG Rui-bo1; QIU Ya-feng2; WANG Juan3
（1.Xinxiang Medical University,Xinxiang 453003,Henan Province,China;2.Nanyang Psychiatric Hospital，Graduate Training Base of Xinxiang Medical University，Nanyang 473000，Henan Province，China；3.The Second Affiliated Hospital of Xinxiang Medical University，Xinxiang 453000，Henan Province，China）
关键词:
阿立哌唑; 奥氮平; 神经认知功能
Keywords:
aripiprazole; olanzapine; neurocognitive function
分类号:
R749.3
DOI:
10.7683/xxyxyxb.2016.02.009
文献标志码:
A
摘要:
目的　比较阿立哌唑、奥氮平对首发精神分裂症神经认知功能损害的治疗效果。方法　80例首发精神分裂症患者随机分为阿立哌唑组和奥氮平组，分别在治疗前和治疗6个月后，采用成套认知功能霍普金斯词汇学习测验-修订版（HVLT-R）、简易视觉空间记忆测试-修订版（BVMT-R）、空间广度测验（SSS）、词语流畅性测验（VF）、Stroop单词测验（SWT）、Stroop颜色测验（SCT）、Stroop色-词测验（SCWT）及WAIS数字符号测验（DST）评定患者的神经认知功能；并与正常对照组30例健康人的神经认知测验结果进行比较。结果　奥氮平组、阿立哌唑组分别有36例、35例完成试验；治疗前2组患者PANSS量表阳性症状分、阴性症状分、一般病理症状分及总分比较差异均无统计学意义（P>0.05）；治疗6个月后，2组患者PANSS量表阳性症状分、阴性症状分、一般病理症状分及总分均较治疗前显著降低（P<0.01），但2组患者PANSS量表阳性症状分、阴性症状分、一般病理症状分及总分比较差异均无统计学意义（P>0.05）。治疗前，阿立哌唑组和奥氮平组患者各项认知功能评分比较差异均无统计学意义（P>0.05）；阿立哌唑组患者各项认知功能评分均低于正常对照组（P<0.01）；奥氮平组患者SSS顺行评分与正常对照组比较差异无统计学意义（P>0.05），其余认知功能评分均低于正常对照组（P<0.01）。与治疗前比较，阿立哌唑组患者治疗6个月后HVLT-R评分、BVMT-R评分、SSS顺行和逆行评分、SWT评分、SCWT评分均增高（P<0.01），但VF评分、DST评分、SCT评分差异无统计学意义（P>0.05）；奥氮平组患者治疗6个月后BVMT-R评分、DST评分、SCT评分、SWCT评分均增高（P<0.01），但HVLT-R评分、SSS顺行和逆行评分、VF评分、SWT评分差异无统计学意义（P>0.05）。治疗6个月后，阿立哌唑组和奥氮平组患者BVMT-R、SSS认知评分与正常对照组比较差异均无统计学意义（P>0.05），HVMT-R、VF、DST、SWT、SCT、SWCT评分均低于对照组（P<0.01）；阿立哌唑组患者HVMT-R、SSS顺行、SSS逆行评分较奥氮平组增高（P<0.01），BVMT-R、VF、DST、SWT、SCT、SWCT评分与奥氮平组比较差异均无统计学意义（P>0.05）。结论　奥氮平和阿立哌唑对首发精神分裂症患者有相似的临床治疗效果，对神经认知功能的改善有各自的特点。
Abstract:
Objective　To compare the efficacy of olanzapine and aripiprazole on the neurocognitive function in patients with first-episode schizophrenia.Methods　Eighty first-episode schizophrenia patients without any medicine were randomly divided into olanzapine group and aripiprazole group.The neurocognitive function was examined by Hopkins verbal learning test-revised（HVLT-R），brief visuospatial memory test-revised（BVMT-R），spatial span subtest（SSS），verbal fluency test（VF），Stroop word test（SWT），Stroop color test（SCT），Stroop color-word test（SCWT） and digit-symbol test（DST）before treatment and at six months after treatment.Then the results was compared with the neurocognitive scores of normal control group in which included 30 healthy persons.Results　Thirty-six cases in olanzapine group and thirty-five cases in aripiprazole group completed six months trial.There was no statistical significance before treatment in the score of positive symptoms，negative symptoms，pathological symptoms and the total score of positive and negative syndrome scale（PANSS）（P>0.05）.After six months treatment，the scores of positive symptoms，negative symptoms，pathological symptoms and the total score of PANSS in the two groups were significantly lower than that before treatment（P<0.01）.But there was no statistically significant difference in the score of positive symptoms，negative symptoms，pathological symptoms and the total score of PANSS between the two groups（P>0.05）.Before treatment，there was no statistical significance in cognitive function score betweenolanzapine group and aripiprazole group（P>0.05）.The cognitive function score of patients in aripiprazole group was lower than that of normal control group（P<0.01）.But there was no statistically significant difference between olanzapine group and normal control group in SSS anterograde score（P>0.05），and the rest of the cognitive function scores in olanzapine group were lower than that of normal control group（P<0.01）.Compared with those before treatment，the HVLT，BVMT-R，SSS anterograde and retrograde scores and SWT，SCWT score after six months treatment in aripiprazole group were higher（P<0.01），while there was no statistical significant difference in VF，DST，SCT score after six months treatment in aripiprazole group（P>0.05）.The BVMT-R，DST，SCT，SWCT scores after six months treatment in olanzapine group were higher compared with those before treatment（P<0.01），while there was no statistical significant difference in HVLT，SSS anterograde and retrograde score and VF，SWT score（P>0.05）.After six months treatment，the cognitive score of BVMT-R，SSS in aripiprazole group and olanzapine group had no statistical significance difference compared with that in control group（P>0.05）；while HVMT-R，VF，DST，SWT，SCT，SWCT scores were lower than those in normal control group（P<0.01）.The HVMT-R score，SSS anterograde and retrograde score in aripiprazole group were higher than those in olanzapine group（P<0.01），but there was no significant difference in BVMT-R，VF，DST，SWT，SCT，SWCT score between aripiprazole group and olanzapine group（P>0.05）.Conclusion　Aripiprazole and olanzapine have similar efficacy on patients with first-episode schizophrenia，and each of them has special characteristic and advantage on the improvement of neurocognitive function.

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更新日期/Last Update: 2016-02-05