[1] Papp J,Kovacs ME,Olah E.Germline MLH1 and MSH2 mutational〖JP2〗 spectrum including frequent large genomic aberrations in Hungarian 〖JP〗hereditary nonpolyposis colorectal cancer families:implications for genetic testing[J].World J Gastroenterol,2007,13(19):2727-2732.
[2] 郑 树.结直肠肿瘤基础与临床实践[M].北京:人民卫生出版社,2006:140-141.
[3] Wang J,Luo MH,Zhang ZX,et al.Clinical and molecular analysis of hereditary nonpolyposis colorectal cancer in Chinese colorectal cancer patients[J].World J Gastroenterol,2007,13(10):1612-1617.[4] 金黑鹰,崔 龙,孟荣贵,等.遗传性非息肉病性结直肠癌家族多原发癌的特点[J].中华胃肠外科杂志,2001,4(7):165-166.
[5] Colombino M,Cossu A,Manca A,et al.Prevalence and prognostic role of microsatellite instability in patients with rectal carcinoma[J].Ann Oncol,2002,13(9):1447-1453
[6] Chialina SG,Fornes C,Landi C,et al.Microsatellite instability analysis in hereditary nonpolyposis colorectal cancer using the bethesda consensus panel of microsatellite markers in the absence of proband normal tissue[J].BMC Med Genet,2006(7):5.
[7] Bian Y,Caldes T,Wijnen J,et al.TGFBR16A may contribute to hereditary colorectal cancer[J].J Clin Oncol,2005,23(13):3074-3078.
[8] 刘善润,王振军,赵 博,等.遗传性非息肉病性结直肠癌患者的临床特点及hMSH2与hMLH1种系突变的筛查[J].中华医学杂志,2004,84(11):714-717.
[9] 金黑鹰,崔 龙.中国人遗传性非息肉病性结直肠癌临床病理特征分析[J].中华胃肠外科杂志,2005,8(13):316-318.
[10] 袁 瑛,曹文明,蔡善荣,等.中国人遗传性非息肉病性结直肠癌家系的临床表型分析[J].中华肿瘤杂志,2006, 28(7):36-38
[11] 顾国利,周晓武,王石林.遗传性非息肉病性大肠癌的研究进展[J].世界华人消化杂志,2007,15(29):3115-3121
[12] 袁 瑛,张苏展,郑 树.中国人遗传性大肠癌筛检标准的实施方案[J].中华肿瘤杂志,2004,26(12):191-192
[13] Liu SR,Zhao B,Wang ZJ,et al.Clinical features and mismatch repair gene mutation screening in Chinese patients with hereditary nonpolyposis colorectal cancer[J].World J Gastroenterol,2004,10(18):2647-2651.
[14] Lynch HT.Hereditary nonpolyposis colorectal cancer[J].Semin Surg Oncol,2000,18(20):305-313.
[15] Kurzawskia G,Safranowb K,Suchya J,et al.Mutation analysis of 〖JP3〗MLH1 and MSH2 genes performed by denaturing highperformance liquid chromatography[J].J Biochem Biophys Methods,2002,51(1):89-100.
[16] Fidalgo P,Almeida MR,West S,et al. Detection of mutations in mismatch repair genes in Portuguese families with hereditary non polyposis colorectal cancer by a multimethod approach[J].Eur J Hum Genet,2000,8(1):49-53.
[17] HolinskiFeder E,MullerKoch Y,Friedl W,et al.DHPLC mutation analysis of the hereditary nonpolyposis colonrectal cancer genes hMLH1 and hMSH2[J].Biochem Biophys Methods,2001,47(12):21-22.
[18] Lynch HT,Boland CR,Gong G,et al.Phenotypic and genotypic heterogeneity in the Lynch syndrome: diagnostic,surveillance and management implications[J].Eur J Hum Genet,2006,14(4):390- 402.
[19] 张 宏,王 简,盛剑秋,等.遗传性非息肉病性结直肠癌家系临床特征及诊断标准分析[J].胃肠病学和肝病学杂志,2005,14(10):186-189
[20] Steinbach G,Lynch P,Phillips R,et al.The effect of celecoxib:a cyclooxygenase2 inhibitor in familial adenomatous polyposis[J].N Engl J Med,2000,342(26):1946-1952.
[21] 盛剑秋,李世荣,杨欣艳,等.遗传性非息肉病性大肠癌和家族性腺瘤性息肉病腺瘤的预防性干预治疗[J].中华医学杂志,2006,86(14):526-529.
[22] 房殿春.遗传性非息肉病性大肠癌的诊断与治疗[J].中华消化内镜杂志,2002,19(7):190-192.
[23] Nemoto T,Kubota S,Ishida H,et al.Ornithine decarboxylase,mitogenactivated protein kinase and matrix metalloproteinase2 expressions in human colon tumors[J].World J Gastroenterol,2005,11(20):3065-3069.
[24] 顾国利,王石林,李捷雷,等.基质金属蛋白酶-7和组织抑制因子-2表达与遗传性非息肉病性大肠癌患者肿瘤侵袭转移关系的研究[J].中华医学杂志,2006,86(18):3367-3370.
[25] Wagner A,Tops C,Wijnen JT,et al. Genetic testing in hereditary nonpolyposis colorectal cancer families with a MSH2,MLH1,orMSH6 mutation[J]. J Med Genet, 2002,39(11):833- 837.
[26] Shia J,Ellis NA,Paty PB,et al.Value of histopathology in predicting microsatellite instability in hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer[J].Am J Surg Pathol,2003,27(22):1407-1417
[27] Church J,Simmang C.Practice parameters for the treatment of patients with dominantly inherited colorectal cancer(Familiar adenomatous polyposis and hereditary nonpolyposis colorectal cancer) [J].Dis Colon Rectum,2003,46(14):1001-1012
[28] Geho DH,Petricoin EF,Liotta LA.Blasting into the microworld of tissue proteomics:a new window on cancer[J].Clin Cancer Res,2004,10(3):981-987.
[29] Fields S.Proteomics.Proteomics in genomeland[J].Science,2001,291(5507):1221-1224.
[30] 范乃军,盛新华,高春芳.表面增强激光解吸离子化飞行时间质谱及其在结直肠癌蛋白质组学研究中的应用[J].新乡医学院学报,2008,25(4):419-422.
[31] 陈主初.肿瘤蛋白质组学的研究进展[J].癌症,2004,23(2):113-117.