[1]魏玉磊,杨建丽,董赓.先天性肾上腺皮质增生症新生儿血清睾酮与肝肾功能的相关性[J].新乡医学院学报,2024,(4):369-371.[doi:10.7683/xxyxyxb.2024.04.013]
　WEI Yulei,YANG JianLi,DONG Geng.Correlation between serum testosterone and liver and kidney function in neonatal children with congenital adrenal hyperplasia[J].Journal of Xinxiang Medical University,2024,(4):369-371.[doi:10.7683/xxyxyxb.2024.04.013]
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先天性肾上腺皮质增生症新生儿血清睾酮与肝肾功能的相关性
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
期数:
2024年4
页码:
369-371
栏目:
临床研究
出版日期:
2024-04-05

文章信息/Info

Title:
Correlation between serum testosterone and liver and kidney function in neonatal children with congenital adrenal hyperplasia
作者:
魏玉磊; 杨建丽; 董赓
（郑州大学附属儿童医院/河南省儿童医院 郑州儿童医院检验科/郑州市儿童感染与免疫重点实验室,河南　郑州450000）
Author(s):
WEI Yulei; YANG JianLi; DONG Geng
(Children′s Hospital Affiliated to Zhengzhou University,Henan Children′s Hospital,Laboratory Department of Zhengzhou Children′s Hospital,Zhengzhou Key Laboratory of Children′s Infection and Immunity,Zhengzhou 450000,Henan Province,China)
关键词:
新生儿; 先天性肾上腺皮质增生症; 肝肾功能; 睾酮
Keywords:
newborn; congenital adrenal hyperplasia; liver and kidney function; testosterone
分类号:
R722.1
DOI:
10.7683/xxyxyxb.2024.04.013
文献标志码:
A
摘要:
目的　探讨先天性肾上腺皮质增生症（CAH）新生儿血清睾酮与肝肾功能的相关性。
方法　选择2019年1月至2022年6月郑州大学附属儿童医院收治的38例CAH新生儿作为观察组；另选择同期本院体检健康新生儿38例作为对照组。比较2组新生儿肝肾功能指标血清丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、碱性磷酸酶（ALP）、总蛋白 (TP)、白蛋白 (ALB)、球蛋白（GLB）、γ-谷氨酰转肽酶 (GGT)、肌酐（Scr）、尿酸（UA）、血尿素氮（BUN）水平，并分析各指标与睾酮的相关性。
结果　观察组与对照组新生儿的性别、年龄、出生体质量、体温、脉搏、血压和血清ALT、AST、ALP水平比较差异均无统计学意义（P>0.05）；观察组与对照组新生儿血清睾酮、TP、ALB、GLB、GGT、Scr、UA、BUN水平比较差异均有统计学意义（P<0.05）。相关性分析结果显示，TP、ALB、GLB、Scr、UA、BUN水平与睾酮呈正相关（r=0.604、0.519、0.456、0.523、0.434、0.510，P<0.05）。
结论　CAH新生儿TP、ALB、GLB、Scr、UA、BUN与睾酮水平呈正相关，随着血清睾酮水平增加，肝分泌功能增强，肾功能损伤程度加重。
Abstract:
Objective　To explore the correlation between liver and kidney function and serum testosterone in neonatal children with congenital adrenal hyperplasia (CAH).
Methods　A total of 38 CAH neonates admitted to the Children′s Hospital Affiliated to Zhengzhou University from January 2019 to June 2022 were selected as the observation group.Another 38 healthy newborns in this hospital during the same period were selected as the control group.Liver and kidney function indexes of neonates in the two groups were compared,including serum alanine aminotransferase (ALT),aspartate aminotransferase (AST),alkaline phosphatase (ALP),total protein (TP),albumin (ALB),globulin (GLB) and γ-glutamyltranspeptidase (GGT),serum creatinine (Scr),uric acid (UA),blood urea nitrogen (BUN) levels,and the correlation between each index and testosterone were analyzed.
Results　There was no statistically significant differences in gender,age,birth weight,body temperature,pulse,blood pressure and serum ALT,AST and ALP levels of neonates between the observation group and control group (P>0.05),while there were statistically significant differences in serum testosterone,TP,ALB,GLB,GGT,Scr,UA and BUN of neonates between the observation group and control group (P<0.05).Correlation analysis showed that the levels of TP,ALB,GLB,Scr,UA and BUN were positively correlated with testosterone (r=0.604,0.519,0.465,0.523,0.434,0.510;P<0.05).
Conclusion　TP,ALB,GLB,Scr,UA and BUN are positively correlated with testosterone levels in CAH neonates.With the increase in serum testosterone levels,liver secretion function is enhanced,and the degree of renal impairment is aggravated.

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更新日期/Last Update: 2024-04-05