[1]张萍心,柴立民,冯桂宇,等.炎症因子对再生障碍性贫血免疫机制的影响研究进展[J].新乡医学院学报,2024,(3):298-300.[doi:10.7683/xxyxyxb.2024.03.018]
　ZHANG Pingxin,CHAI Limin,FENG Guiyu,et al.Advances in the effect of inflammatory factors on immune mechanism of aplastic anemia[J].Journal of Xinxiang Medical University,2024,(3):298-300.[doi:10.7683/xxyxyxb.2024.03.018]
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炎症因子对再生障碍性贫血免疫机制的影响研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
期数:
2024年3
页码:
298-300
栏目:
综述
出版日期:
2024-03-05

文章信息/Info

Title:
Advances in the effect of inflammatory factors on immune mechanism of aplastic anemia
作者:
张萍心; 柴立民; 冯桂宇; 李东阳; 孙嵩; 刘蔚; 张英凯
（北京中医药大学东直门医院重点实验室，北京　100700）
Author(s):
ZHANG Pingxin; CHAI Limin; FENG Guiyu; LI Dongyang; SUN Song; LIU Wei; ZHANG Yingkai
(Key Laboratory of Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)
关键词:
再生障碍性贫血; 调节性T细胞; 凋亡相关因子/凋亡相关因子配体信号通路; 微RNAs
Keywords:
aplastic anemia; regulatory T cell; factor-related apoptosis/factor-related apoptosis ligand signaling pathway; microRNAs
分类号:
R556.5
DOI:
10.7683/xxyxyxb.2024.03.018
文献标志码:
A
摘要:
再生障碍性贫血（AA）的发病机制复杂，与造血干细胞缺陷、骨髓微环境异常、免疫功能障碍、体细胞突变等有关，而免疫机制在其中起着重要作用。本文从调节性T细胞减少、凋亡相关因子/凋亡相关因子配体信号通路导致造血干细胞减少及炎症因子刺激微RNAs诱导靶基因表达异常与调节性T细胞功能缺失等方面综述AA的发病机制，以期为临床治疗提供思路与方法。
Abstract:
The pathogenesis of aplastic anemia (AA) is complex and associated with hematopoietic stem cell defect,abnormal bone marrow microenvironment,immune dysfunction,and somatic mutation,in which the immune mechanism plays an important role.This article reviews the pathogenesis of AA from the following aspects:regulatory T cell reduction,hematopoietic stem cell reduction caused by factor-related apoptosis/factor-related apoptosis ligand signaling pathway,aberrant target gene expression induced by inflammatory factor-stimulated microRNAs,and regulatory T cell dysfunction,so as to provide ideas and methods for clinical practice.

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更新日期/Last Update: 2024-03-05