[1]马新乐,徐杰,秦金霞.肿块型乳腺癌患者肿瘤组织中Ki-67表达与超声特征的相关性[J].新乡医学院学报,2024,(3):240-244.[doi:10.7683/xxyxyxb.2024.03.008]
　MA Xinle,XU Jie,QIN Jinxia.Correlation between Ki-67 expression in tumor tissue and ultrasound features of patients with mass breast cancer[J].Journal of Xinxiang Medical University,2024,(3):240-244.[doi:10.7683/xxyxyxb.2024.03.008]
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肿块型乳腺癌患者肿瘤组织中Ki-67表达与超声特征的相关性
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
期数:
2024年3
页码:
240-244
栏目:
临床研究
出版日期:
2024-03-05

文章信息/Info

Title:
Correlation between Ki-67 expression in tumor tissue and ultrasound features of patients with mass breast cancer
作者:
马新乐; 徐杰; 秦金霞
（新乡市中心医院超声科一/新乡医学院第四临床学院，河南　新乡　453000）
Author(s):
MA Xinle; XU Jie; QIN Jinxia
(The First Department of Ultrasound,Xinxiang Central Hospital/The Fourth Clinical College,Xinxiang Medical University,Xinxiang 453000,Henan Province,China)
关键词:
肿块型乳腺癌; Ki-67表达; 超声影像
Keywords:
mass breast cancer; Ki-67 expression; ultrasonic imaging
分类号:
R737.9
DOI:
10.7683/xxyxyxb.2024.03.008
文献标志码:
A
摘要:
目的　分析肿块型乳腺癌患者肿瘤组织中Ki-67表达与超声特征的相关性。
方法　选择2020年1月至2022年12月新乡市中心医院收治的肿块型乳腺癌患者90例（90个肿块）为研究对象，根据肿瘤组织中Ki-67表达情况将患者分为Ki-67高表达组（n=53）和Ki-67低表达组（n=37）。比较2组患者的超声造影（CEUS）定性、定量特征，剪切波弹性成像（SWE）定性、定量特征，以及彩色多普勒血流显像（CDFI）特征；并采用多因素logistic回归分析肿块型乳腺癌患者Ki-67表达与超声特征的相关性。
结果　Ki-67高表达组CEUS灌注缺损患者占比显著高于Ki-67低表达组（P<0.05）；2组患者的CEUS边界、均匀性、增强水平、增强后病灶范围、方向比较差异无统计学意义（P>0.05）。Ki-67高表达组患者的峰值强度、上升时间、半降时间显著高于Ki-67低表达组（P<0.05）；2组患者的到达时间、达峰时间、平均通过时间比较差异无统计学意义（P>0.05）。Ki-67高表达组具有SWE硬环征患者占比显著高于Ki-67低表达组（P<0.05）；2组具有SWE黑洞征患者占比比较差异无统计学意义（P>0.05）。Ki-67高表达组患者病灶与周围组织弹性模量比值水平显著高于Ki-67低表达组（P<0.05）；2组患者的最大弹性模量值、平均弹性模量值、最小弹性模量值比较差异无统计学意义（P>0.05）。Ki-67高表达组CDFI下病灶大小为2~5 cm、边缘有毛刺患者占比显著高于Ki-67低表达组（P<0.05）；2组患者CDFI下病灶形状、方位、钙化情况比较差异无统计学意义（P>0.05）。灌注缺损、硬环征、边缘有毛刺与肿块型乳腺癌患者Ki-67高表达有关（P<0.05）。
结论　肿块型乳腺癌的超声特征对Ki-67表达有预测作用，其中灌注缺损、硬环征、边缘有毛刺与Ki-67阳性表达具有相关性。
Abstract:
Objective　To analyze the correlation between Ki-67 expression in tumor tissue and ultrasound features of patients with mass breast cancer.
Methods　A total of 90 patients (90 masses) with mass breast cancer admitted to Xinxiang Central Hospital from January 2020 to December 2022 were selected and divided into the Ki-67 high expression group (n=53) and Ki-67 low expression group (n=37) according to the expression of Ki-67 in tumor tissue.The qualitative and quantitative characteristics of contrast-enhanced ultrasound (CEUS),shear wave elastography (SWE) and color doppler flow imaging (CDFI) were compared between the two groups,and their correlation with Ki-67 expression in patients with mass breast cancer was analyzed by multivariate logistic regression.
Results　The proportion of CEUS perfusion defects patients in the Ki-67 high expression group was significantly higher than that in the Ki-67 low expression group (P<0.05).There was no significant difference in CEUS margin,homogeneity,enhancement level,post-enhancement lesion range and direction between the two groups (P>0.05).The maximum intensity,rise time,and half time in the Ki-67 high expression group were significantly higher than those in the Ki-67 low expression group (P<0.05).There was no significant difference in arrival time,time to peak,and mean transit time between the two groups (P>0.05).The proportion of hard ring signs in SWE of patients in the Ki-67 high expression group was significantly higher than that in the Ki-67 low expression group (P<0.05),while there was no significant difference in the proportion of SWE black hole signs between the two groups (P>0.05).The elastic modulus ratio between lesions to surrounding parenchyma of patients in Ki-67 high expression group was higher than that in the Ki-67 low expression group (P<0.05).There was no significant difference in the maximum,average,and minimum elastic modulus between the two groups (P>0.05).In the Ki-67 high expression group,the proportion of patient where tumor size under CDFI was 2-5 cm,and the proportion of patients with burrs on the lesion edge were higher than those in the Ki-67 low expression group (P<0.05).There was no significant difference in the shape,location and calcification of the lesions under CDFI between the two groups (P>0.05).Perfusion defect,hard ring sign and edge burr were associated with high Ki-67 expression in patients with mass breast cancer (P<0.05).
Conclusion　Ultrasonographic features of mass breast cancer can predict Ki-67 expression.Perfusion defect,hard ring sign,and edge burr are related to Ki-67 positive expression.

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更新日期/Last Update: 2024-03-05