[1]平玉坤,张锋,宋景贵.富氢水对脑卒中的治疗作用及其机制研究进展[J].新乡医学院学报,2023,40(12):1191-1194.[doi:10.7683/xxyxyxb.2023.12.017]
　PING Yukun,ZHANG Feng,SONG Jinggui.Research progress on therapeutic effect and mechanism of hydrogen rich water on stroke[J].Journal of Xinxiang Medical University,2023,40(12):1191-1194.[doi:10.7683/xxyxyxb.2023.12.017]
点击复制

富氢水对脑卒中的治疗作用及其机制研究进展
分享到：

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
40卷
期数:
2023年12
页码:
1191-1194
栏目:
综述
出版日期:
2023-12-05

文章信息/Info

Title:
Research progress on therapeutic effect and mechanism of hydrogen rich water on stroke
作者:
平玉坤; 张锋; 宋景贵
（新乡医学院第二附属医院河南省生物精神病学重点实验室，河南　新乡　453003）
Author(s):
PING Yukun; ZHANG Feng; SONG Jinggui
(Henan Key Laboratory of Biological Psychiatry,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453003,Henan Province,China)
关键词:
富氢水; 脑卒中; 氧化应激; 作用机制
Keywords:
hydrogen rich water; stroke; oxidative stress; mechanism
分类号:
R743
DOI:
10.7683/xxyxyxb.2023.12.017
文献标志码:
A
摘要:
脑卒中是一种常见的神经系统疾病，具有发病率、病死率、致残率高的特点。富氢水是一种含有高浓度氢气的饮用水，可用于治疗脑卒中，主要通过减轻炎症反应、细胞凋亡、氧化应激等发挥作用。本文就富氢水对脑卒中的治疗作用及其机制的研究进展进行综述，以期为脑卒中的治疗方案提供更多思路。
Abstract:
Stroke is a common nervous system disease with high incidence rate,mortality rate and disability rate.Hydrogen rich water is a type of drinking water containing high concentrations of hydrogen gas,which can be used to treat stroke.Hydrogen rich water mainly plays a role by reducing inflammatory reactions,cell apoptosis,oxidative stress reactions,etc.This article reviews the research progress on the therapeutic effect and mechanism of hydrogen rich water on stroke,in order to provide insights for the treatment plan of stroke.

参考文献/References:

［1］　KATAN M,LUFT A.Global burden of stroke［J］.Semin Neurol,2018,38(2):208-211.
［2］　KHOSHNAM S E,WINLOW W,FARZANEH M,et al.Pathogenic mechanisms following ischemic stroke［J］.Neurol Sci,2017,38(7):1167-1186.
［3］　薛洋洋,宋景贵.氢气的生物学作用机制及其在临床疾病中的应用研究进展［J］.新乡医学院学报,2023,40(5):483-489.
XUE Y Y,SONG J G.Research progress on biological mechanism of hydrogen and its application in clinical diseases［J］.J Xinxiang Med Univ,2023,40(5):483-489.
［4］　LEE D,CHOI J I.Hydrogen-rich water improves cognitive ability and induces antioxidative,antiapoptotic,and anti-inflammatory effects in an acute ischemia-reperfusion injury mouse model［J］.Biomed Res Int,2021,2021：9956938.
［5］　IIDA A,NOSAKA N,YUMOTO T,et al.The clinical application of hydrogen as a medical treatment［J］.Acta Med Okayama,2016,70(5):331-337.
［6］　ROCHETTE L,ZELLER M,COTTIN Y,et al.Antitumor activity of protons and molecular hydrogen：underlying mechanisms［J］.Can-cers,2021,13(4)：893.
［7］　HANCOCK J T,RUSSELL G.Downstream signalling from molecular hydrogen［J］.Plants (Basel),2021,10(2)：367.
［8］　COLE A R,RAZA A,AHMED H,et al.Safety of inhaled hydrogen gas in healthy mice［J］.Med Gas Res,2019,9(3):133-138.
［9］　KUROKAWA R,HIRANO S I,ICHIKAWA Y,et al.Preventing explosions of hydrogen gas inhalers［J］.Med Gas Res,2019,9(3):160-162.
［10］　GE L,YANG M,YANG N N,et al.Molecular hydrogen：a preventive and therapeutic medical gas for various diseases［J］.Oncotarget,2017,8(60)：102653-102673.
［11］　LIU B Y,QIN S C.Different types of molecular hydrogen donors and their pharmacokinetics in vivo［J］.Acta physiol Sin,2019,71(2)：371-377.
［12］　NAGATANI K,NAWASHIRO H,TAKEUCHI S,et al.Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia：initial clinical studies［J］.Med Gas Res,2013,3：13.
［13］　HOU Z,LUO W,SUN X,et al.Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury［J］.Brain Res Bull,2012,88(6):560-565.
［14］　KUBOTA M,SHIMMURA S,KUBOTA S,et al.Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model［J］.Invest Ophthalmol Vis Sci,2011,52(1):427-433.
［15］　YOKOTA T,KAMIMURA N,IGARASHI T,et al.Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina［J］.Clin Exp Ophthalmol,2015,43(6):568-577.
［16］　TIAN Y,ZHANG Y,WANG Y,et al.Hydrogen,a novel therapeutic molecule,regulates oxidative stress,inflammation,and apoptosis［J］.Front Physiol,2021,12:789507.
［17］　KATO S,MATSUOKA D,MIWA N.Antioxidant activities of nano-bubble hydrogen-dissolved water assessed by ESR and 2,2′-bipyridyl methods［J］.Mater Sci Eng C Mater Biol Appl,2015,53:7-10.
［18］　BOTEK M,KREJ Cˇ J,MCKUNE A J,et al.Hydrogen rich water improved ventilatory,perceptual and lactate responses to exercise［J］.Int J Sports Med,2019,40(14)：879-885.
［19］　DONG G,FU J,BAO D,et al.Short-term consumption of hydrogen-rich water enhances power performance and heart rate recovery in dragon boat athletes：evidence from a pilot study［J］.Int J Environ Res Public Health,2022,19(9)：5413.
［20］　TIMN R,OLCINA G,GONZLEZ-CUSTODIO A,et al.Effects of 7-day intake of hydrogen-rich water on physical performance of trained and untrained subjects［J］.Biol Sport,2021,38(2):269-275.
［21］　KOROVLJEV D,STAJER V,OSTOJIC J,et al.Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease：a randomized controlled pilot trial［J］.Clin Res Hepatol Gastroenterol,2019,43(6)：688-693.
［22］　HAN A L,PARK S H,PARK M S.Hydrogen treatment protects against cell death and senescence induced by oxidative damage［J］.J Microbiol Biotechnol,2017,27(2)：365-371.
［23］　ITO M,HIRAYAMA M,YAMAI K,et al.Drinking hydrogen water and intermittent hydrogen gas exposure,but not lactulose or continuous hydrogen gas exposure,prevent 6-hydorxydopamine-induced Parkinson′s disease in rats［J］.Med Gas Res,2012,2(1)：15.
［24］　MAIDA C D,NORRITO R L,DAIDONE M,et al.Neuroinfla-mmatory mechanisms in ischemic stroke：focus on cardioembolic stroke,background,and therapeutic approaches［J］.Int J Mol Sci,2020,21(18)：6454.
［25］　刘颖.富氢水对大鼠创伤性脑损伤半暗带区新生血管生成的影响及相关机制的研究［D］.苏州：苏州大学,2017.
LIU Y.Effect and the mechanism of hydrogen-rich water on the angiogenesis in penumbra brain tissue with traumatic brain injury rats［D］.Suzhou：Soochow University,2017.
［26］　RODRIGO R,FERNNDEZ-GAJARDO R,GUTIRREZ R,et al.Oxidative stress and pathophysiology of ischemic stroke：novel therapeutic opportunities［J］.CNS Neurol Disord Drug Targets,2013,12(5):698-714.
［27］　LI L,LIU T,LIU L,et al.Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury［J］.J Bioenerg Biomembr,2019,51(6)：393-402.
［28］　TAMAKI N,ORIHUELA-CAMPOS R C,FUKUI M,et al.Hydrogen-rich water intake accelerates oral palatal wound healing via activation of the Nrf2/antioxidant defense pathways in a rat model［J］.Oxid Med Cell Longev,2016,2016：5679040.
［29］　SHI Q,CHEN C,DENG W H,et al.Hydrogen-rich saline attenuates acute hepatic injury in acute necrotizing pancreatitis by inhibiting inflammation and apoptosis,involving JNK and p38 mitogen-activated protein kinase-dependent reactive oxygen species［J］.Pancreas,2016,45(10):1424-1431.
［30］　LI X,LI L,LIU X,et al.Attenuation of cardiac ischaemia-reperfusion injury by treatment with hydrogen-rich water［J］.Curr Mol Med,2019,19(4)：294-302.
［31］　SIM M,KIM C S,SHON W J,et al.Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults：a randomized,double-blind,controlled trial［J］.Sci Rep,2020,10(1)：12130.
［32］　袁佳,王迪芬,刘颖,等.富氢水对创伤性脑损伤大鼠Nrf2表达及氧化应激损伤的影响［J］.中华危重病急救医学,2015,27(11)：911-915.
YUAN J,WANG D F,LIU Y,et al.Effects of hydrogen rich water on the expression of Nrf 2 and the oxidative stress in rats with traumatic brain injury［J］.Chin Crit Care Med,2015,27(11)：911-915.
［33］　LU R,LIU Y,WANG D.Protective effect of hydrogen-rich water on oxidative stress cell model and the impact of the phosphatidylinositol 3 kinase/protein kinase B pathway［J］.Chin Crit Care Med,2019,31(6)：762-767.
［34］　LIU M,YUAN H,YIN J,et al.Effect of hydrogen-rich water on radiation-induced cognitive dysfunction in rats［J］.Radiat Res,2020,193(1)：16-23.
［35］　FESKE S K.Ischemic stroke［J］.Am J Med,2021,134(12)：1457-1464.
［36］　CUI Y,ZHANG H,JI M,et al.Hydrogen-rich saline attenuates neuronal ischemia—reperfusion injury by protecting mitochondrial function in rats［J］.J Surg Res,2014,192(2):564-572.
［37］　HAN L,TIAN R,YAN H,et al.Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins［J］.Brain Res,2015,1615：129-138.
［38］　CHU X,CAO L,YU Z,et al.Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation［J］.J Neuroinflammation,2019,16(1)：104.
［39］　LI D,AI Y.Hydrogen saline suppresses neuronal cell apoptosis and inhibits the p38 mitogen-activated protein kinase-caspase-3 signaling pathway following cerebral ischemia-reperfusion injury［J］.Mol Med Rep,2017,16(4)：5321-5325.
［40］　FANG Y,GAO S,WANG X,et al.Programmed cell deaths and potential crosstalk with blood-brain barrier dysfunction after hemo-rrhagic stroke［J］.Front Cell Neurosci,2020,14：68.
［41］　SHAO A,WU H,HONG Y,et al.Hydrogen-rich saline attenuated subarachnoid hemorrhage-induced early brain injury in rats by suppressing inflammatory response：possible involvement of NF-κB pathway and NLRP3 inflammasome［J］.Mol Neurobiol,2016,53(5)：3462-3476.
［42］　HONG Y,SHAO A,WANG J,et al.Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage：possible role of the Akt/GSK3β signaling pathway［J］.PLoS One,2014,9(4)：e96212.
［43］　JIANG B,LI Y,DAI W,et al.Hydrogen-rich saline alleviates early brain injury through regulating of ER stress and autophagy after experimental subarachnoid hemorrhage［J］.Acta Cir Bras,2021,36(8)：e360804.
［44］　HONG Y,GUO S,CHEN S,et al.Beneficial effect of hydrogen-rich saline on cerebral vasospasm after experimental subarachnoid hemorrhage in rats［J］.J Neurosci Res,2012,90(8)：1670-1680.

相似文献/References:

[1]孟凡超,许予明,李枢,等.脑卒中患者入院时间及其部分影响因素的调查[J].新乡医学院学报,1997,14(04):396.
[2]粱爱华.脑卒中吞咽障碍62例康复护理[J].新乡医学院学报,2003,20(03):224.
[3]梁爱华.脑卒中吞咽障碍62例康复护理[J].新乡医学院学报,2003,20(03):224.
[4]曹红军,张　静,尤海峰,等.盐酸舍曲林在脑卒中抑郁症恢复中的作用[J].新乡医学院学报,2003,20(01):053.
[5]曹红军,张静,尤海峰,等.盐酸舍曲林在脑卒中抑郁症恢复中的作用[J].新乡医学院学报,2003,20(01):053.
[6]袁彬,袁宇.脱水治疗脑卒中患者合并心功能不全34例 [J].新乡医学院学报,2005,22(04):000.
[7]侯学荣,李素芳.脑卒中失语患者的早期语言康复指导[J].新乡医学院学报,2005,22(04):386.
[8]张朝辉,赵建民,李 静,等.卒中后抑郁患者社会心理因素的研究 [J].新乡医学院学报,2012,29(10):774.
[9]崔长富,谷　娟,李转会,等. 综合康复治疗对急性脑卒中后吞咽障碍及卒中相关性肺炎的影响[J].新乡医学院学报,2015,32(08):782.
[10]张钦聪,史福平,李会敏,等.脑卒中后抑郁相关免疫因素研究进展[J].新乡医学院学报,2016,33(9):819.[doi:10.7683/xxyxyxb.2016.09.023]
　ZHANG Qincong,SHI Fuping,LI Huimin,et al.Research progress on immune factors related to post-stroke depression[J].Journal of Xinxiang Medical University,2016,33(12):819.[doi:10.7683/xxyxyxb.2016.09.023]

更新日期/Last Update: 2023-12-05