[1]郭源辉,段佳佳,刘传鑫,等.核因子E2相关因子2介导的铁死亡在糖尿病心肌病中的发病机制及其靶向治疗研究进展[J].新乡医学院学报,2023,40(12):1178-1183.[doi:10.7683/xxyxyxb.2023.12.015]
　GUO Yuanhui,DUAN Jiajia,LIU Chuanxin,et al.Research progress on pathogenesis and targeted therapy of ferroptosis mediated by nuclear factor E2-related factor 2 in diabetic cardiomyopathy[J].Journal of Xinxiang Medical University,2023,40(12):1178-1183.[doi:10.7683/xxyxyxb.2023.12.015]
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核因子E2相关因子2介导的铁死亡在糖尿病心肌病中的发病机制及其靶向治疗研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
40卷
期数:
2023年12
页码:
1178-1183
栏目:
综述
出版日期:
2023-12-05

文章信息/Info

Title:
Research progress on pathogenesis and targeted therapy of ferroptosis mediated by nuclear factor E2-related factor 2 in diabetic cardiomyopathy
作者:
郭源辉1; 2; 3; 段佳佳1; 4; 刘传鑫1; 2; 3; 姜宏卫1; 2; 3
(1.河南科技大学临床医学院,河南　洛阳　471003；2.河南科技大学第一附属医院内分泌代谢中心,河南　洛阳　471003；3.河南省罕见病实验室，河南　洛阳　471003；4.河南科技大学第一附属医院检验科,河南　洛阳　471003)
Author(s):
GUO Yuanhui1; 2; 3; DUAN Jiajia1; 4; LIU Chuanxin1; 2; 3; JIANG Hongwei1; 2; 3
(1.Clinical Medical College，Henan University of Science and Technology,Luoyang 471003,Henan Province,China;2.Endocrinology and Metabolism Center，the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,Henan Province,China;3.Rare Disease Laboratory of Henan Province,Luoyang 471003,Henan Province,China;4.Department of Clinical Laboratory,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,Henan Province,China)
关键词:
铁死亡; 糖尿病心肌病; 核因子E2相关因子2; 靶向治疗; 氧化应激
Keywords:
ferroptosis; diabetic cardiomyopathy; nuclear factor E2-related factor 2; targeted therapy; oxidative stress
分类号:
R587.1
DOI:
10.7683/xxyxyxb.2023.12.015
文献标志码:
A
摘要:
糖尿病心肌病为糖尿病患者心力衰竭和死亡的主要原因之一。糖尿病心肌病的发生发展过程中存在铁死亡的典型证据，说明铁死亡与糖尿病心肌病相关。活性氧大量生成与抗氧化能力丧失所导致的氧化应激被认为是导致糖尿病心肌病的主要机制。作为氧化应激反应关键调控因子之一，核因子E2相关因子2（NRF2）及其靶基因在预防与治疗糖尿病心肌病中发挥重要作用。本文对铁死亡机制和糖尿病心肌病发病机制进行概述，阐述二者之间的关系，并重点就NRF2在糖尿病心肌病发生发展过程中分子机制及其靶向治疗效果进行综述。
Abstract:
Diabetic cardiomyopathy is one of the leading causes of heart failure and death in diabetic patients.There is classic evidence of ferroptosis in the development of diabetic cardiomyopathy,which proves that ferroptosis is correlated with the diabetic cardiomyopathy.Oxidative stress caused by excessive production of reactive oxygen species and loss of antioxidant capacity is considered to be the main mechanism leading to diabetic cardiomyopathy.As one of the key regulatory factors of oxidative stress,nuclear factor E2-related factor 2 (NRF2) and its target gene play an important role in the prevention and treatment of diabetic cardiomyopathy.This article summarizes the mechanism of ferroptosis and the pathogenesis of diabetes cardiomyopathy,and expounds the relationship between them,and focuses on the molecular mechanism of NRF2 in the development of diabetic cardiomyopathy and its targeted treatment effect.

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更新日期/Last Update: 2023-12-05