[1]闫晓辉,赵娟茹,梁衍.血小板内皮聚集受体-1基因多态性与间歇性血液透析患者血管通路感染的相关性[J].新乡医学院学报,2023,40(12):1151-1155.[doi:10.7683/xxyxyxb.2023.12.010]
　YAN Xiaohui,ZHAO Juanru,LIANG Yan.Correlation between platelet endothelial aggregation receptor-1 gene polymorphisms and vascular access infections in intermittent hemodialysis patients[J].Journal of Xinxiang Medical University,2023,40(12):1151-1155.[doi:10.7683/xxyxyxb.2023.12.010]
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血小板内皮聚集受体-1基因多态性与间歇性血液透析患者血管通路感染的相关性
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
40卷
期数:
2023年12
页码:
1151-1155
栏目:
临床研究
出版日期:
2023-12-05

文章信息/Info

Title:
Correlation between platelet endothelial aggregation receptor-1 gene polymorphisms and vascular access infections in intermittent hemodialysis patients
作者:
闫晓辉1; 赵娟茹2; 梁衍1
（1.陕西省人民医院肾内科，陕西　西安　710065；2.陕西省人民医院老年病科，陕西　西安　710065）
Author(s):
YAN Xiaohui1; ZHAO Juanru2; LIANG Yan1
(1.Department of Nephrology,Shaanxi Provincial People′s Hospital,Xi′an 710065,Shaanxi Province,China;2.Department of Geriatrics,Shaanxi Provincial People′s Hospital,Xi′an 710065,Shaanxi Province,China)
关键词:
血小板内皮聚集受体-1; 基因多态性; 间歇性血液透析; 血管通路感染
Keywords:
platelet endo thelial aggregation receptor 1; genetic polymorphism; intermittent hemodialysis; vascular access infection
分类号:
R446
DOI:
10.7683/xxyxyxb.2023.12.010
文献标志码:
A
摘要:
目的　探讨血小板内皮聚集受体-1（PEAR1）基因多态性与间歇性血液透析（IHD）患者血管通路感染的相关性。
方法　选择2019年1月至2022年1月于陕西省人民医院收治的105例接受IHD治疗的患者为观察组，另选取同期入院体检的健康者50例为对照组，采用荧光定量聚合酶链式反应法检测2组受试者PEAR1基因多态性。另外，观察组患者进行影像学、血清学、病原学等检查，根据是否发生血管通路感染将患者分为感染组和未感染组，比较2组患者的临床资料，采用单因素分析和多因素logsitic回归分析PEAR1基因多态性与IHD患者血管通路感染的相关性。
结果　观察组和对照组受试者PEAR1基因位点均有G和A 2个等位基因，检出3种基因型，包括野生型（GG）、突变杂合型（GA）、突变纯合型（AA）。观察组患者的GG基因型频率、G等位基因型频率均高于对照组（P<0.05）；观察组和对照组受试者基因位点等位基因频率均符合哈迪-温伯格平衡（P>0.05）；单因素分析显示，感染组和未感染组患者性别比例、体温、体质量指数、血压、三酰甘油、总胆固醇、低密度脂蛋白、高密度脂蛋白、GA和AA基因型频率及高血脂史、抽烟史、饮酒史占比比较差异无统计学意义（P>0.05）；未感染组患者年龄、透析时间≥3 a占比、透析频率1周≥3次占比、PEAR1 GG基因型频率、PEAR1 G等位基因频率、肌钙蛋白T水平、白细胞水平、血小板计数、血细胞比容、降钙素原水平、中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值、高血压史占比、糖尿病史占比均低于感染组，PEAR1 A等位基因频率均高于感染组（P<0.05）。Logistic回归分析显示，透析时间长、年龄大及高透析频率、高中性粒细胞/淋巴细胞比值、高血小板/淋巴细胞比值和PEAR1 G等位基因是影响IHD患者发生血管通路感染的危险因素（P<0.05）。
结论　IHD患者存在PEAR1基因型表达异常，其中PEAR1基因型为GG的患者发生血管通路感染的风险更高，可将其作为早期预测血液透析患者血管通路感染的有效因子。
Abstract:
Objective　To explore the correlation between platelet endothelial aggregation receptor-1 (PEAR1) gene polymorphisms and vascular access infections in intermittent hemodialysis (IHD) patients.
Methods　Totally 105 patients who received IHD treatment in Shaanxi Provincial People′s Hospital from January 2019 to January 2022 were selected as the observation group,and 50 healthy people who were admitted to the hospital for physical examination at the same period were selected as the control group,and PEAR1 gene polymorphisms of the subjects in the two groups were tested by polymerase chain reaction.In addition,the patients in the observation group underwent imaging,serology,and pathogenesis,and they were divided into infected group and uninfected group according to whether vascular access infections occurred,and the clinical data of patients between the two groups were compared,and the correlation between PEAR1 gene polymorphisms and vascular access infections in IHD patients was analyzed by using univariate and multifactorial logsitic regression.
Results　There were two alleles G and A at the PEAR1 gene locus of patients in the observation group and control group;and three genotypes were detected,including wild-type (GG),mutant heterozygous (GA),and mutant pure (AA).The frequency of the GG genotype and the frequency of the G allele genotype of the patients in the observation group were higher than those in the control group (P<0.05);the allele frequencies of the gene loci of the subjects in the observation group and the control group were in accordance with the Hardy-Weinberg equilibrium (P>0.05).Univariate analysis showed that there was no statistically significant difference in the sex ratio,body temperature,body mass index,blood pressure,triglyceride,total cholesterol,low-density lipoprotein,high-density lipoprotein,frequency of the GA and AA genotypes,percentage of history of hyperlipidemia,percentage of history of cigarette smoking,and percentage of history of alcohol consumption of patients between the infected group and uninfected group (P>0.05).The age the percentage of dialysis duration >3 years,the percentage of dialysis frequency ≥3 times in 1 week,the frequency of PEAR1 GG genotype,the frequency of PEAR1 G allele,the troponin T level,leukocyte level,platelet count level,hematocrit level,procalcitonin level,neutrophil/lymphocyte ratio,platelet/lymphocyte ratio,hypertension history and diabetes history of patients in the uninfected group were all lower than those in the infected group,while the frequency of PEAR1 A allele was higher than that in the infected group (P<0.05).Logistic regression analysis showed that long dialysis duration,older age and high dialysis frequency,high neutrophil/lymphocyte ratio,high platelet/lymphocyte ratio,and PEAR1 G allele were risk factors for developing vascular access infections in patients with IHD (P<0.05).
Conclusion　IHD patients have PEAR1 genotype expression abnormality,in which the risk of vascular access infection in patients with PEAR1 genotype GG is higher,which can be used as an effective factor for the early prediction of vascular access infection in hemodialysis patients.

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更新日期/Last Update: 2023-12-05