参考文献/References:
［1］ SUNG H,FERLAY J,SIEGEL R L,et al.Global cancer statistics 2020:globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries［J］.CA Cancer J Clin,2021,71(3):209-249.
［2］ 曹毛毛,李贺,孙殿钦,等.2000—2019年中国胃癌流行病学趋势分析［J］.中华消化外科杂志,2021,20(1):102-109.
CAO M M,LI H,SUN D Q,et al.Epidemiological trend analysis of gastric cancer in China from 2000 to 2019［J］.Chin J Dig Surg,2021,20(1):102-109.
［3］ WANG F H,ZHANG X T,LI Y F,et al.The Chinese society of clinical oncology (CSCO):clinical guidelines for the diagnosis and treatment of gastric cancer,2021［J］.Cancer Commun (Lond),2021,41(8):747-795.
［4］ ZENG H,CHEN W,ZHENG R,et al.Changing cancer survival in China during 2003-15:a pooled analysis of 17 population-based cancer registries［J］.Lancet Glob Health,2018,6(5):e555-e567.
［5］ OERUM S,MEYNIER V,CATALA M,et al.A comprehensive review of m6A/m6Am RNA methyltransferase structures［J］.Nucleic Acids Res,2021,49(13):7239-7255.
［6］ TIAN S,LAI J,YU T,et al.Regulation of gene expression associated with the N6-methyladenosine(m6A) enzyme system and its significance in cancer［J］.Front Oncol,2020,10:623634.
［7］ FU J,CUI X,ZHANG X,et al.The role of m6A ribonucleic acid modification in the occurrence of atherosclerosis［J］.Front Genet,2021,12:733871.
［8］ LI Y,GU J,XU F,et al.Molecular characterization,biological function,tumor microenvironment association and clinical significance of m6A regulators in lung adenocarcinoma［J］.Brief Bioinform,2021,22(4):bbaa225.
［9］ ZHANG T,ZHANG S W,ZHANG S Y,et al.m6A-express:uncovering complex and condition-specific m6A regulation of gene expression［J］.Nucleic Acids Res,2021,49(20):e116.
［10］ ZHANG H,SHI X,HUANG T,et al.Dynamic landscape and evolution of m6A methylation in human［J］.Nucleic Acids Res,2020,48(11):6251-6264.
［11］ AN S,HUANG W,HUANG X,et al.Integrative network analysis identifies cell-specific trans regulators of m6A［J］.Nucleic Acids Res,2020,48(4):1715-1729.
［12］ ZHANG B,WU Q,LI B,et al.m(6)A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer［J］.Mol Cancer,2020,19(1):53.
［13］ NIU Y,LIN Z,WAN A,et al.RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3［J］.Mol Cancer,2019,18(1):46.
［14］ YIN H,ZHANG X,YANG P,et al.RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming［J］.Nat Commun,2021,12(1):1394.
［15］ CHEN X,XU M,XU X,et al.METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer［J］.Mol Cancer,2020,19(1):106.
［16］ ZHOU S,BAI Z L,XIA D,et al.FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β-catenin through mRNA demethylation［J］.Mol Carcinog,2018,57(5):590-597.
［17］ YUE Y,LIU J,CUI X,et al.VIRMA mediates preferential m(6)A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation［J］.Cell Discov,2018,4:10.
［18］ WANG T,KONG S,TAO M,et al.The potential role of RNA N6-methyladenosine in cancer progression［J］.Mol Cancer,2020,19(1):88.
［19］ WANG Q,CHEN C,DING Q,et al.METTL3-mediated m(6)A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance［J］.Gut,2020,69(7):1193-1205.
［20］ YUE B,SONG C,YANG L,et al.METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer［J］.Mol Cancer,2019,18(1):142.
［21］ LIN S,LIU J,JIANG W,et al.METTL3 promotes the proliferation and mobility of gastric cancer cells［J］.Open Med (Wars),2019,14:25-31.
［22］ LIU T,YANG S,SUI J,et al.Dysregulated N6-methyladenosine methylation writer METTL3 contributes to the proliferation and migration of gastric cancer［J］.J Cell Physiol,2020,235(1):548-562.
［23］ ZHOU W,XIAN Q,WANG Q,et al.m6A methyltransferase 3 promotes the proliferation and migration of gastric cancer cells through the m6A modification of YAP1［J］.J Oncol,2021,2021:8875424.
［24］ HUO F C,ZHU Z M,ZHU W T,et al.METTL3-mediated m(6)A methylation of SPHK2 promotes gastric cancer progression by targeting KLF2［J］.Oncogene,2021,40(16):2968-2981.
［25］ WANG G,ZHANG Z,XIA C.Long non-coding RNA LINC00240 promotes gastric cancer progression via modulating miR-338-5p/METTL3 axis［J］.Bioengineered,2021,12(2):9678-9691.
［26］ HU H,KONG Q,HUANG X X,et al.Longnon-coding RNA BLACAT2 promotes gastric cancer progression via the miR-193b-5p/METTL3 pathway［J］.J Cancer,2021,12(11):3209-3221.
［27］ KANG J,HUANG X,DONG W,et al.MicroRNA-1269b inhibits gastric cancer development through regulating methyltransferase-like 3 (METTL3)［J］.Bioengineered,2021,12(1):1150-1160.
［28］ LIU X,XIAO M,ZHANG L,et al.The m6A methyltransferase METTL14 inhibits the proliferation,migration,and invasion of gastric cancer by regulating the PI3K/AKT/mTOR signaling pathway［J］. J Clin Lab Anal,2021,35(3):e23655.
［29］ HU N,JI H.N6-methyladenosine (m6A)-mediated up-regulation of long noncoding RNA LINC01320 promotes the proliferation,migration,and invasion of gastric cancer via miR495-5p/RAB19 axis［J］.Bioengineered,2021,12(1):4081-4091.
［30］ LIU J,YUE Y,HAN D,et al.A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation［J］.Nat Chem Biol,2014,10(2):93-95.
［31］ RUSZKOWAKA A.METTL16,methyltransferase-like protein 16:current insights into structure and function［J］.Int J Mol Sci,2021,22(4):2176.
［32］ WANG X K,ZHANG Y W,WANG C M,et al.METTL16 promotes cell proliferation by up-regulating cyclin D1 expression in gastric cancer［J］.J Cell Mol Med,2021,25(14):6602-6617.
［33］ WANG D,QU X,LU W,et al.N6-methyladenosine RNA demethylase FTO promotes gastric cancer metastasis by down-regulating the m6A methylation of ITGB1［J］.Front Oncol,2021,11:681280.
［34］ WANG J,WANG J,GU Q,et al.The biological function of m6A demethylase ALKBH5 and its role in human disease［J］.Cancer Cell Int,2020,20:347.
［35］ ZHANG J,GUO S,PIAO H Y,et al.ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1［J］.J Physiol Biochem,2019,75(3):379-389.
［36］ LIU S,LI G,LI Q,et al.The roles and mechanisms of YTH domain-containing proteins in cancer development and progression［J］.Am J Cancer Res,2020,10(4):1068-1084.
［37］ LIAO J,WEI Y,LIANG J,et al.Insight into the structure,physiological function,and role in cancer of m6A readers-YTH domain-containing proteins［J］.Cell Death Discov,2022,8(1):137.
［38］ CHEN X Y,LIANG R,YI Y C,et al.The m6A reader YTHDF1 facilitates the tumorigenesis and metastasis of gastric cancer via USP14 Translation in an m6A-dependent manner［J］. Front Cell Dev Biol,2021,9:647702.
［39］ SHEN X,ZHAO K,XU L,et al.YTHDF2 inhibits gastric cancer cell growth by regulating FOXC2 signaling pathway［J］.Front Genet,2020,11:592042.
［40］ 张杰,皮静楠,刘越,等.敲低MGC-803胃癌细胞YTHDF2抑制其增殖并促进其凋亡［J］.细胞与分子免疫学杂志,2017,33(12):1628-1634.
ZHANG J,PI J N,LIU Y,et al.Knockdown of YTH N6-methyladenosine ＲNA binding protein 2 ( YTHDF2 ) inhibits proliferation and promotes apoptosis in MGC-803 gastric cancer cells［J］.Chin J Cell Mol Immunol,2017,33(12):1628-1634.
［41］ YUT,RAN L,ZHAO H,et al.Circular RNA circ-TNPO3 suppre-sses metastasis of GC by acting as a protein decoy for IGF2BP3 to regulate the expression of MYC and SNAIL［J］. Mol Ther Nucleic Acids,2021,26:649-664.
［42］ CHEN Y,LIU J,WANG W,et al.High expression of hnRNPA1 promotes cell invasion by inducing EMT in gastric cancer［J］.Oncol Rep,2018,39(4):1693-1701.
［43］ PENG W Z,ZHAO J,LIU X,et al.hnRNPA2B1 regulates the alternative splicing of BIRC5 to.promote gastric cancer progression［J］.Cancer Cell Int,2021,21(1):281.