[1]吴奇东,章怡祎.沉默信息调节因子2相关酶1抗氧化应激作用在抗动脉粥样硬化中的作用机制研究进展[J].新乡医学院学报,2023,40(9):887-891.[doi:10.7683/xxyxyxb.2023.09.017]
 WU Qidong,ZHANG Yiyi.Research progress on the mechanism of antioxidant stress induced by silent information regulation 2 homolog 1 in anti-atherosclerosis[J].Journal of Xinxiang Medical University,2023,40(9):887-891.[doi:10.7683/xxyxyxb.2023.09.017]
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沉默信息调节因子2相关酶1抗氧化应激作用在抗动脉粥样硬化中的作用机制研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
40卷
期数:
2023年9
页码:
887-891
栏目:
综述
出版日期:
2023-09-05

文章信息/Info

Title:
Research progress on the mechanism of antioxidant stress induced by silent information regulation 2 homolog 1 in anti-atherosclerosis
作者:
吴奇东章怡祎
(上海中医药大学附属龙华医院ICU,上海 200032)
Author(s):
WU QidongZHANG Yiyi
(Department of ICU,Longhua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)
关键词:
沉默信息调节因子2相关酶1动脉粥样硬化氧化应激去乙酰化
Keywords:
silent mating type information regulation 2 homolog 1atherosclerosisoxidative stressdeacetylation
分类号:
R543.5
DOI:
10.7683/xxyxyxb.2023.09.017
文献标志码:
A
摘要:
沉默信息调节因子2相关酶1(SIRT1)是一种烟酰胺腺嘌呤二核苷酸依赖性组蛋白去乙酰化酶,可将组蛋白及非组蛋白底物去乙酰化,进而调节细胞的多种生物过程,如基因转录、炎症反应、新陈代谢、细胞凋亡、氧化应激及自身免疫等。SIRT1可通过抗氧化应激,抑制炎症反应,有效改善血管内皮功能,从而发挥抗动脉粥样硬化的作用。本文就SIRT1的抗氧化应激作用在抗动脉粥样硬化中的作用机制研究进展进行综述。
Abstract:
Silent information regulator 2 homolog 1 (SIRT1) is a nicotinamide adenine dinucleotide dependent histone deacetylase,which can deacetylate histone and non-histone substrates,and then regulate a variety of biological processes of cells,such as gene transcription,inflammatory reaction,metabolism,apoptosis,oxidative stress and autoimmunity.SIRT1 can play an anti-atherosclerosis role by antioxidative stress,inhibiting inflammatory reaction,and effectively improving vascular endothelial function.This article reviews the research progress on the mechanism of SIRT1′s antioxidative stress in anti-atherosclerosis.

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更新日期/Last Update: 2023-09-05