[1]王开,钟佩玲,王昌铭.缺血性脑卒中相关生物标志物多组学研究进展[J].新乡医学院学报,2023,40(6):587-591.[doi:10.7683/xxyxyxb.2023.06.016]
　WANG Kai,ZHONG Peiling,WANG Changming.Research advances in multi-omics of biomarkers related to ischemic stroke[J].Journal of Xinxiang Medical University,2023,40(6):587-591.[doi:10.7683/xxyxyxb.2023.06.016]
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缺血性脑卒中相关生物标志物多组学研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
40卷
期数:
2023年6
页码:
587-591
栏目:
综述
出版日期:
2023-06-05

文章信息/Info

Title:
Research advances in multi-omics of biomarkers related to ischemic stroke
文章编号:
20230616
作者:
王开1; 钟佩玲2; 王昌铭3
（1.中国人民解放军联勤保障部队第九四五医院麻醉科，四川　雅安　625000；2.中国人民解放军联勤保障部队第九四五医院骨科，四川　雅安　625000；3．中国人民解放军联勤保障部队第九八九医院神经内科，河南　洛阳　471000）
Author(s):
WANG Kai1; ZHONG Peiling2; WANG Changming3
(1．Department of Anesthesiology，the 945th Hospital of the Joint Logistics Support Force of the People′s Liberation Army of China，Ya′an 625000;2．Department of Osteology，the 945th Hospital of the Joint Logistics Support Force of the People′s Liberation Army of China，Ya′an 625000;3．Department of Neurology，the 989th Hospital of the Joint Logistics Support Force of the People′s Liberation Army of China，Luoyang 471000)
关键词:
缺血性脑卒中; 生物标志物; 多组学; 基因组学; 转录组学; 蛋白组学; 代谢组学
Keywords:
ischemia stroke; biomarkers; multi-omics; genomics; transcriptomics; proteomics; metabolomics
分类号:
R743.3
DOI:
10.7683/xxyxyxb.2023.06.016
文献标志码:
A
摘要:
生物标志物对缺血性脑卒中的早期诊断及预后评估具有一定的指导意义，已成为当前研究热点。相较于单一类别生物标志物，多组学通过整合基因组学、转录组学、蛋白质组学及代谢组学，可系统反映缺血性脑卒中患者复杂的病理生理过程，在缺血性脑卒中早期诊断方面具备一定的潜力。本文基于缺血性脑卒中相关生物标志物多组学研究现状，对缺血性脑卒中基因组学、转录组学、蛋白质组学、代谢组学相关生物标志物研究进展进行综述，以期为缺血性脑卒中的早期诊断提供参考，并为进一步研究提供更多思路。
Abstract:
The biomarkers have certain guiding significance for the early diagnosis and prognosis evaluation of ischemic stroke，and have become a research hotspot．Compared with a single category of biomarkers，multi-omics can systematically reflect the complex pathophysiological processes of patients with ischemic stroke by integrating genomics，transcriptomics，proteomics and metabolomics，which has certain potential in the early diagnosis of ischemic stroke．Based on the current status of multi-omics researches on biomarkers related to ischemic stroke，this article reviews the research progress of biomarkers related to genomics，transcriptomics，proteomics and metabolomics of ischemic stroke，in order to provide references for the early diagnosis of ischemic stroke and provide more ideas for further research.

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更新日期/Last Update: 2023-06-13