[1]司艳凤,张媛媛,毕凌云.激活蛋白-1在骨代谢相关信号通路中的作用研究进展[J].新乡医学院学报,2023,40(1):097-100.[doi:10.7683/xxyxyxb.2023.01.018]
　SI Yanfeng,ZHANG Yuanyuan,BI Lingyun.Research progress of effect of activator protein-1 in bone metabolism related signaling pathway[J].Journal of Xinxiang Medical University,2023,40(1):097-100.[doi:10.7683/xxyxyxb.2023.01.018]
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激活蛋白-1在骨代谢相关信号通路中的作用研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
40卷
期数:
2023年1期
页码:
097-100
栏目:
综述
出版日期:
2023-01-05

文章信息/Info

Title:
Research progress of effect of activator protein-1 in bone metabolism related signaling pathway
作者:
司艳凤; 张媛媛; 毕凌云
（新乡医学院第一附属医院儿科，河南　卫辉　453100)
Author(s):
SI Yanfeng; ZHANG Yuanyuan; BI Lingyun
(Department of Pediatrics,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,Henan Province,China)
关键词:
激活蛋白-1; 骨代谢; 核因子-κB受体活化因子; 信号通路
Keywords:
activator protein-1; bone metabolism; receptor-activator of nuclear factor kappa beta; signal pathway
分类号:
R692.3+4
DOI:
10.7683/xxyxyxb.2023.01.018
文献标志码:
A
摘要:
激活蛋白-1（AP-1）是调节细胞增殖、分化和凋亡的关键转录因子。AP-1可通过调控成骨细胞和破骨细胞的增殖、分化和凋亡，参与骨骼生长的生理及病理过程。近年来研究发现，AP-1作为核因子-κB受体活化因子配体/核因子-κB受体活化因子信号通路的重要转录因子，主要通过核因子-κB和Jun氨基末端激酶、细胞外信号调节激酶和p38信号通路调节破骨细胞形成，参与骨代谢过程，其与骨质疏松、骨肿瘤等代谢性骨疾病的发生发展相关，这为代谢性骨疾病提供了新的治疗靶点。本文就AP-1在骨代谢相关信号通路的作用研究进展作一综述。
Abstract:
Activator protein-1 (AP-1) is a key transcription factor that regulates cell proliferation,differentiation and apoptosis.AP-1 can participate in the physiological and pathological process of bone growth by regulating the proliferation,differentiation and apoptosis of osteoblasts and osteoclasts.Recent studies have found that AP-1 as an important transcription factor in nuclear factor kappa beta ligand/receptor-activator of nuclear factor kappa beta signaling pathway,regulates osteoclast formation and participates in bone metabolism mainly through nuclear factor kappa beta and Jun N-terminal kinase,extracellular regulated protein kinases and p38 signaling pathways,and which is related to the occurrence and development of metabolic bone diseases such as osteoporosis and bone tumors,this provides a new therapeutic target for metabolic bone diseases.This article reviews the research progress of AP-1 in bone metabolism related signal pathways.

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更新日期/Last Update: 2023-01-05