[1]刘万年,张国富,刘迟利,等.河南省新乡县农村成年居民非酒精性脂肪肝的患病现况及影响因素分析[J].新乡医学院学报,2022,39(11):1025-1030.[doi:10.7683/xxyxyxb.2022.11.005]
　LIU Wannian,ZHANG Guofu,LIU Chili,et al.Analysis of the prevalence and influencing factors of non-alcoholic fatty liver disease of adult rural residents in Xinxiang County,Henan Province[J].Journal of Xinxiang Medical University,2022,39(11):1025-1030.[doi:10.7683/xxyxyxb.2022.11.005]
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河南省新乡县农村成年居民非酒精性脂肪肝的患病现况及影响因素分析
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
39
期数:
2022年11
页码:
1025-1030
栏目:
临床研究
出版日期:
2022-11-05

文章信息/Info

Title:
Analysis of the prevalence and influencing factors of non-alcoholic fatty liver disease of adult rural residents in Xinxiang County,Henan Province
作者:
刘万年; 张国富; 刘迟利; 姜静; 王永斌; 李文龙; 杨中智; 吴卫东
（新乡医学院公共卫生学院环境卫生与工程中心，河南　新乡　453003）
Author(s):
LIU Wannian; ZHANG Guofu; LIU Chili; JIANG Jing; WANG Yongbin; LI Wenlong; YANG Zhongzhi; WU Weidong
(Environmental Health and Engineering Center,School of Public Health,Xinxiang Medical University,Xinxiang 453003,Henan Province,China)
关键词:
非酒精性脂肪肝; 横断面研究; 影响因素; 患病率
Keywords:
non-alcoholic fatty liver disease; cross-sectional study; influencing factor; prevalence rate
分类号:
R575.5
DOI:
10.7683/xxyxyxb.2022.11.005
文献标志码:
A
摘要:
目的　调查河南省新乡县农村成年居民非酒精性脂肪肝（NAFLD）的患病现况并分析其影响因素。方法　本研究基于2017年河南省农村常见慢性非传染性疾病前瞻性队列研究中新乡县横断面调查的数据，于2017年4~7月采用随机整群抽样的方法在河南省新乡县随机抽取七里营镇的6个村作为样本地区，对所有在该地区居住满6个月的18岁及以上居民进行问卷调查、体格检查和实验室指标检测。本研究共纳入4 457人作为研究对象，排除232人过量饮酒后，根据是否患有NAFLD分为NAFLD组和对照组。采用多因素二元logistic回归分析NAFLD的影响因素。结果　4 457名研究对象中，2 157例被诊断为NAFLD，NAFLD患病率为48.40%，年龄标准化患病率为43.37%；男性和女性患病率分别为50.75%和46.71%，年龄标准化患病率分别为50.60%和38.49%。4 457名研究对象中，18~29岁、30~39岁、40~49岁、50~59岁研究对象的NAFLD总体患病率随年龄的增加呈升高趋势（χ2=124.235，P<0.05），50~59岁、60~69岁、≥70岁研究对象的NAFLD总体患病率随年龄的增加呈降低趋势（χ2=9.809，P<0.05）；18~29岁、30~39岁、40~49岁男性的NAFLD患病率随年龄的增加呈升高趋势（χ2=14.821，P<0.05），40~49岁、50~59岁、60~69岁、≥70岁男性的NAFLD患病率随年龄的增加呈降低趋势（χ2=20.981，P<0.05）；18~29岁、30~39岁、40~49岁、50~59岁女性的NAFLD患病率随年龄的增加呈升高趋势（χ2=178.267，P<0.05）,50~59岁、60~69岁、≥70岁女性的NAFLD患病率比较差异无统计学意义（χ2=2.113，P>0.05）；18~29岁、30~39岁、40~49岁男性的NAFLD患病率显著高于同年龄段女性，50~59岁、60~69岁、≥70岁女性的NAFLD患病率显著高于同年龄段男性（P<0.05）。不同口味人群的NAFLD患病率比较差异无统计学意义（P>0.05），不同年龄、性别、体质量指数（BMI）、文化程度、职业、牛奶摄入频率人群NAFLD患病率比较差异均有统计学意义（P<0.05）。NAFLD组与对照组研究对象的BMI、腰围、臀围、腰臀比、收缩压、舒张压以及空腹血糖、糖化血红蛋白（HbA1c）、三酰甘油（TG）、总胆固醇、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、碱性磷酸酶、直接胆红素、血清尿酸、血尿素、血清肌酐水平比较差异均有统计学意义（P<0.001）。多因素二元logistic回归分析显示，BMI、腰围、HbA1c、TG、LDL-C、血清尿酸为NAFLD患病的危险因素（P<0.05）；年龄、HDL-C、血清肌酐为NAFLD患病的保护因素（P<0.05）。结论　河南省新乡县农村成年居民NAFLD患病率较高，年龄、BMI、腰围、HbA1c、TG、HDL-C、LDL-C、血清尿酸和血清肌酐是NAFLD患病的影响因素。
Abstract:
Objective　To investigate the prevalence of non-alcoholic fatty liver disease (NAFLD) in adult rural residents in Xinxiang County,Henan Province and analyze its influencing factors.Methods　Based on the data from the cross-sectional survey of Xinxiang County in the prospective cohort study on common chronic non-communicable diseases in rural areas of Henan Province in 2017,this study randomly selected Qiliying town from Xinxiang County,Henan Province by random cluster sampling from April to July 2017.Six villages in the town were taken as sample areas,and all residents aged 18 and above who had lived in the area for 6 months were subjected to questionnaire survey,physical examination and laboratory index testing.A total of 4 457 people were included in this study as the research subjects.After excluding 232 people due to excessive drinking,the subjects were divided into the NAFLD group and the control group according to whether they had NAFLD.The influencing factors of NAFLD were analyzed by multivariate binary logistic regression.Results　Among the 4 457 subjects,2 157 subjects were diagnosed with NAFLD,the NAFLD prevalence rate was 48.40%,and the age-standardized prevalence rate was 43.37%;the male and female prevalence rates were 50.75% and 46.71%,respectively,and the age-standardized prevalence rates were 50.60% and 38.49%,respectively.Among the 4 457 subjects,the overall prevalence rates of NAFLD in subjects aged 18-29,30-39,40-49 and 50-59 years old increased with age (χ2=124.235，P<0.05),the overall prevalence rates of NAFLD in subjects aged 50-59,60-69 and ≥70 years old decreased with age (χ2=9.809，P<0.05);the prevalence rates of NAFLD in men aged 18-29,30-39 and 40-49 years old increased with age (χ2=14.821，P<0.05),and the prevalence rates of NAFLD in men aged 40-49,50~59,60-69 and ≥70 years old decreased with age (χ2=20.981，P<0.05);the prevalence rates of NAFLD in women aged 18-29,30-39,40-49 and 50-59 years old increased with age (χ2=178.267，P<0.05);there was no significant difference in the prevalence rate of NAFLD among women aged 50-59,60-69 and ≥70 years old (χ2=2.113,P>0.05).The prevalence rates of NAFLD in men aged 18-29,30-39 and 40-49 years old were significantly higher than those in women in the same age group (P<0.05),and the prevalence rates of NAFLD in women aged 50-59,60-69 and ≥70 years old were significantly higher than those of men in the same age group (P<0.05).There was no significant difference in the prevalence rate of NAFLD among the subjects with different tastes (P>0.05),but there were significant differences in the prevalence rates of NAFLD among the subjects with different ages,genders,BMI,educational level,occupation and milk intake frequency (P<0.05).There were significant differences in the BMI,waist circumference,hip circumference,waist-to-hip ratio,systolic blood pressure,diastolic blood pressure,and the levels of fasting blood glucose,glycated-hemoglobin (HbA1c),triglyceride (TG),total cholesterol,high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C),alanine aminotransferase,aspartate aminotransferase,aspartate aminotransferase,alkaline phosphatase,direct bilirubin,serum uric acid,blood urea,serum creatinine between the NAFLD group and the control group (P<0.001).Multivariate binary logistic regression analysis showed that BMI,waist circumference,HbA1c,TG,LDL-C and serum uric acid were risk factors for NAFLD (P<0.05);age,HDL-C and serum creatinine were protective factors for NAFLD (P<0.05).Conclusion　The prevalence rate of NAFLD among adult rural residents in Xinxiang County,Henan Province is relatively high.The age,BMI,waist circumference,HbA1c,TG,HDL-C,LDL-C,serum uric acid and serum creatinine are influencing factors for NAFLD.

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[1]田莉娜.2型糖尿病伴非酒精性脂肪肝相关因素分析[J].新乡医学院学报,2010,27(04):394.

更新日期/Last Update: 2022-11-05