[1]田林涛,王奇才,杜红宾.垫枕复位联合经皮穿刺椎体成形术和壮腰健骨汤治疗骨质疏松性腰椎压缩骨折疗效观察[J].新乡医学院学报,2022,39(9):816-820.[doi:10.7683/xxyxyxb.2022.09.004]
　TIAN Lintao,WANG Qicai,DU Hongbin.Efficacy of pillow reduction combined with percutaneous vertebroplasty and Zhuangyaojiangu decoction in the treatment of osteoporotic lumbar vertebral compression fracture[J].Journal of Xinxiang Medical University,2022,39(9):816-820.[doi:10.7683/xxyxyxb.2022.09.004]
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垫枕复位联合经皮穿刺椎体成形术和壮腰健骨汤治疗骨质疏松性腰椎压缩骨折疗效观察
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
39
期数:
2022年9
页码:
816-820
栏目:
临床研究
出版日期:
2022-09-05

文章信息/Info

Title:
Efficacy of pillow reduction combined with percutaneous vertebroplasty and Zhuangyaojiangu decoction in the treatment of osteoporotic lumbar vertebral compression fracture
作者:
田林涛; 王奇才; 杜红宾
（新里程安钢总医院骨二科，河南　安阳　455000）
Author(s):
TIAN Lintao; WANG Qicai; DU Hongbin
（The Second Department of Orthopedics,Angang General Hospital,Anyang 455000,Henan Province,China）
关键词:
骨质疏松性腰椎压缩骨折; 垫枕复位; 经皮穿刺椎体成形术; 壮腰健骨汤
Keywords:
osteoporotic lumbar vertebral compression fracture; pillow reduction; percutaneous vertebroplasty; Zhuang-yaojiangu decoction
分类号:
R683.2
DOI:
10.7683/xxyxyxb.2022.09.004
文献标志码:
A
摘要:
目的　探讨垫枕复位联合经皮穿刺椎体成形术（PVP）和壮腰健骨汤治疗骨质疏松性腰椎压缩骨折的效果。方法　选择2016年1月至2021年5月新里程安钢总医院骨科收治的80例骨质疏松性腰椎压缩骨折患者为研究对象，根据治疗方式将患者分为对照组（n=33）和观察组（n=47）。对照组患者采用垫枕复位联合PVP治疗，观察组患者采用垫枕复位联合PVP和壮腰健骨汤治疗。比较2组患者术前及术后10个月伤椎的Cobb角、前缘高度、中段高度、后缘高度以及血清Ⅰ型前胶原羧基端肽（PICP）、骨碱性磷酸酶（BALP）、骨钙素（OCN）水平和伤椎骨密度，记录并比较2组患者不良反应发生情况。结果　术前，2组患者伤椎的Cobb角、前缘高度、中段高度及后缘高度比较差异均无统计学意义（P>0.05）；术后10个月，2组患者伤椎的Cobb角显著小于术前，伤椎前缘高度、中段高度及后缘高度显著大于术前（P<0.05）；术后10个月，观察组患者伤椎Cobb角显著小于对照组，伤椎前缘高度、中段高度及后缘高度显著大于对照组（P<0.05）。术前，2组患者血清PICP、BALP、OCN水平及第2~4腰椎、右股骨颈骨密度比较差异均无统计学意义（P>0.05）；术后10个月，对照组患者血清PICP、BALP、OCN水平及第2~4腰椎、右股骨颈骨密度与术前比较差异无统计学意义（P>0.05），观察组患者血清PICP、BALP、OCN水平及第2~4腰椎、右股骨颈骨密度显著高于术前和对照组（P<0.05）。对照组与观察组患者不良反应发生率分别为12.12%（4/33）、8.51%（4/47）；对照组与观察组患者的不良反应发生率比较差异无统计学意义（χ2=0.023，P>0.05）。观察组患者服药期间均未发生明显药物不良反应。结论　垫枕复位联合PVP和壮腰健骨汤治疗骨质疏松性腰椎压缩骨折可有效增强成骨细胞活性，增加伤椎骨密度，更为有效地促进骨折椎体恢复，且安全性较高。
Abstract:
Objective　To investigate the efficacy of pillow reduction combined with percutaneous vertebroplasty (PVP) and Zhuangyaojiangu decoction in the treatment of osteoporotic lumbar vertebral compression fracture.Methods　A total of 80 patients with osteoporotic lumbar vertebral compression fracture admitted to Department of Orthopedics of Angang General Hospital from January 2016 to May 2021 were selected as the research subjects,and they were divided into the control group (n=33) and the observation group (n=47) according to treatment methods.The patients in the control group were treated with pillow reduction combined with PVP,and the patients in the observation group were treated with pillow reduction combined with PVP and Zhuangyaojiangu decoction.The Cobb angle,anterior edge height,middle segment height,posterior edge height of the injured vertebrae,the serum procollagen type Ⅰ carboxy terminal peptide (PICP),bone alkaline phosphatase (BALP),osteocalcin (OCN) levels and bone mineral density of the injured vertebrae of patients between the two groups were compared before and 10 months after operation.The adverse reactions of patients between the two groups were recorded and compared.Results　There was no significant difference in the Cobb angle,anterior edge height,middle segment height and posterior edge height of the injured vertebra of patients between the two groups before operation (P>0.05).At 10 months after operation,the Cobb angle of the injured vertebra of patients was significantly lower than that before operation,the anterior edge height,middle segment height and posterior edge height of the injured vertebra of patients were significantly higher than those before operation in the two groups (P<0.05);at 10 months after operation,the Cobb angle of the injured vertebra of patients in the observation group was significantly lower than that in the control group,and the anterior edge height,middle segment height and posterior edge height of the injured vertebra of patients were significantly higher than those in the control group (P<0.05).There was no significant difference in the serum PICP,BALP,OCN levels and bone mineral density of lumbar spine L2-L4 and right femoral neck of patients between the two groups before operation (P>0.05);there was no significant difference in serum PICP,BALP,OCN levels and bone mineral density of lumbar spine L2-L4 and right femoral neck of patients before operation compared with those at 10 months after operation in the control group (P>0.05);at 10 months after operation,the serum PICP,BALP,OCN levels and bone mineral density of lumbar spine L2-L4 and right femoral neck of patients in the observation group were significantly higher than those in preoperation and the control group (P<0.05).The incidence of adverse reactions of patients in the control group and the observation group were 12.12% (4/33) and 8.51% (4/47),respectively;there was no significant difference in the incidence of adverse reactions of patients between the two groups (χ2=0.023，P>0.05).The patients in the observation group had no obvious adverse drug reactions during administration period.Conclusion　Pillow reduction combined with PVP and Zhuangyaojiangu decoction in the treatment of osteoporotic lumbar vertebral compression fractures can effectively enhance the activity of osteoblasts,increase the bone mineral density of the injured vertebra,significantly promote the recovery of the fractured vertebral body,and it′s safe and effective.

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更新日期/Last Update: 2022-09-05