[1]杨　翠,韩圣瑾.环状RNA在分化型甲状腺癌中的作用研究进展[J].新乡医学院学报,2022,39(7):680-682.[doi:10.7683/xxyxyxb.2022.07.016]
　YANG Cui,HAN Shengjin.Research progress on the role of circular RNA in differentiated thyroid carcinoma[J].Journal of Xinxiang Medical University,2022,39(7):680-682.[doi:10.7683/xxyxyxb.2022.07.016]
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环状RNA在分化型甲状腺癌中的作用研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
39
期数:
2022年7
页码:
680-682
栏目:
综述
出版日期:
2022-07-05

文章信息/Info

Title:
Research progress on the role of circular RNA in differentiated thyroid carcinoma
作者:
杨　翠1; 韩圣瑾2
（1.皖西卫生职业学院临床医学系病理学教研室，安徽　六安　237005；2.安徽医科大学附属六安医院急诊外科，安徽　六安　237005）
Author(s):
YANG Cui1; HAN Shengjin2
(1.Department of Pathology Teaching and Research Section,Clinical Medicine,West Anhui Health Vocational College,Lu′ an 237005, Anhui Province,China;2.Department of Emergency Surgery,Lu ′an Hospital of Anhui Medical University,Lu′ an237005, Anhui Province,China)
关键词:
分化型甲状腺癌; 环状RNA; 生物学特性
Keywords:
differentiated thyroid carcinoma; circular RNA; biological characteristic
分类号:
R736.1
DOI:
10.7683/xxyxyxb.2022.07.016
文献标志码:
A
摘要:
环状RNA （circRNA）属于一种内源性非编码RNA，可在血清、尿液、唾液等多种体液中被检测到。circRNA 具有促进肿瘤细胞增殖、分化、凋亡、迁移等多种生物学行为的作用。circRNA作为微RNA的“分子海绵”在甲状腺癌组织中表达异常，circRNA能够通过调节下游靶基因的表达影响甲状腺癌的发生与发展。本文就circRNA的生物学特点及其在分化型甲状腺癌中的作用研究进展进行综述。
Abstract:
Circular RNA (circRNA) is an endogenous non-coding RNA,which can be detected in serum,urine,saliva and other body fluids.CircRNA can promote the proliferation,differentiation,apoptosis and migration of tumor cells.CircRNA as a "molecular sponge" of microRNA has abnormal expression in thyroid cancer.CircRNA can affect the occurrence and development of thyroid cancer by regulating the expression of downstream target genes.This article reviews the biological characteristics of circRNA and its role in differentiated thyroid carcinoma.

参考文献/References:

［1］　陈松,高庆军,赵代伟.环状RNA与甲状腺癌关系的研究进展［J］.中国普通外科杂志,2020,29(11):1370-1375.
CHEN S,GAO Q J,ZHAO D W.Research progress of the relationship between circular RNAs and thyroid cancer［J］.Chin J General Surg,2020,29(11):1370-1375.
［2］　杨增娣,杨艳婷,吕永燕,等.不同甲状腺结节大小超声引导下细针穿刺细胞学诊断敏感性和准确性比较［J］.河北医学,2022,28(1):81-85.
YANG Z D,YANG Y T,LYU Y Y,et al.Comparison of the sensitivity and accuracy of ultrasound-guided fine needle aspiration cytology for different thyroid nodule ［J］.Hebei Med,2022,28(1):81-85.
［3］　骆鹏飞,穆夏黎,焦大海,等.甲状腺结节细针穿刺细胞学检查标本充分性的影响因素［J］.中华医学杂志,2020,100(24):1913-1916.
LUO P F,MU X L,JIAO D H,et al.Factors influencing the adequacy of specimens for fine needle aspiration cytology examination of thyroid nodules ［J］.Natl Med J China,2020,100(24):1913-1916.
［4］　WANG H,YAN X,ZHANG H,et al.CircRNA circ_0067934 overexpression correlates with poor prognosis and promotes thyroid carcinoma progression［J］.Med Sci Monit,2019,25:1342-1349.
［5］　谢晓亮,李玉梅,董丽琴,等.环状RNA在甲状腺癌中的研究进展［J］.实用肿瘤杂志,2021,36(2):184-188.
XIE X L,LI Y M,DONG L Q,et al.Research progress of circular RNA in thyroid cancer ［J］.J Pract Oncol,2021,36(2):184-188.
［6］　ZHU G,CHANG X,KANG Y,et al.CircRNA:a novel potential strategy to treat thyroid cancer (review)［J］.Int J Mol Med,2021,48(5):201.
［7］　YANG W,BAI C,ZHANG L,et al.Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis［J］.Medicine (Baltimore),2020,99(47):e23255.
［8］　杜红飞,庞雪利,阳燕,等.老年性白内障患者外周血环状RNA差异表达谱研究［J］.眼科新进展,2020,40(9):849-852.
DU H F,PANG X L,YANG Y,et al.Peripheral blood circRNAs expression profile in patients with senile cataract［J］.Rec Adv Ophthalmol,2020,40 (9):849-852.
［9］　GUO D,LI F,ZHAO X,et al.Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma［J］.Oncol Rep,2020,44(2):519-532.
［10］　TAO L,YANG L,TIAN P,et al.Knockdown of circPVT1 inhibits progression of papillary thyroid carcinoma by sponging miR-126［J］.RSC Adv,2019,9(23):13316-13324.
［11］　LOU W,DING B,WANG J,et al.The involvement of the hsa_circ_0088494-miR-876-3p-CTNNB1/CCND1 axis in carcinogenesis and progression of papillary thyroid carcinoma［J］.Front Cell Dev Biol,2020,8:605940.
［12］　GONG J,KONG X,QI J,et al.CircRNA_104565 promoted cell proliferation in papillary thyroid carcinoma by sponging miR-134［J］.Int J Gen Med,2021,14:179-185.
［13］　NIE C,HAN J,BI W,et al.Circular RNA circ_0000644 promotes papillary thyroid cancer progression via sponging miR-1205 and regulating E2F3 expression［J］.Cell Cycle,2022,21(2):126-139.
［14］　YE M,HOU H,SHEN M,et al.Circular RNA circFOXM1 plays a role in papillary thyroid carcinoma by sponging miR-1179 and regulating HMGB1 expression［J］.Mol Ther Nucleic Acids,2020,19:741-750.
［15］　XIA F,CHEN Y,JIANG B,et al.Hsa_circ_0011385 accelerates the progression of thyroid cancer by targeting miR-361-3p ［J］.Cancer Cell Int,2020,20:49.
［16］　QI Y,HE J,ZHANG Y,et al.Circular RNA hsa_circ_0001666 sponges miR3305p,miR193a5p and miR326,and promotes papillary thyroid carcinoma progression via upregulation of ETV4［J］.Oncol Rep,2021,45(4):50.
［17］　YU F,YU C,LI F,et al.Wnt/β-catenin signaling in cancers and targeted therapies［J］.Signal Transduct Target Ther,2021,6(1):307.
［18］　ZENG L,YUAN S,ZHOU P,et al.Circular RNA PVT1 oncogene (circPVT1) promotes the progression of papillary thyroid carcinoma by activating the Wnt/β-catenin signaling pathway and modulating the ratio of microRNA-195 (miR-195) to vascular endothelial growth factor A (VEGFA) expression［J］.Bioengineered,2021,12(2):11795-11810.
［19］　BI W,HUANG J,NIE C,et al.CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of β-catenin pathway［J］.J Exp Clin Cancer Res,2018,37(1):275-283.
［20］　LONG M Y,CHEN J W,ZHU Y,et al.Comprehensive circular RNA profiling reveals the regulatory role of circRNA_0007694 in papillary thyroid carcinoma［J］.Am J Transl Res,2020,12(4):1362-1378.
［21］　LI C,ZHU L,FU L,et al.CircRNA NRIP1 promotes papillary thyroid carcinoma progression by sponging miR-195-5p and modulating the P38 MAPK and JAK/STAT pathways［J］.Diagn Pathol,2021,16(1):93.
［22］　杜公博,殷德涛.环状RNA在甲状腺乳头状癌中的研究进展［J］.中国普外基础与临床杂志,2020,27(7):890-894.
DU G B,YIN D T.Research progress of circRNAs in thyroid papillary carcinoma［J］.Chin J Bas Clin General Surg,2020,27(7):890-894.
［23］　WU G,ZHOU W,LIN X,et al.CircRASSF2 acts as ceRNA and promotes papillary thyroid carcinoma progression through miR-1178/TLR4 signaling pathway［J］.Mol Ther Nucleic Acids,2020,26:1199.
［24］　XU X,JING J.Advances on circRNAs contribute to carcinogenesis and progression in papillary thyroid carcinoma［J］.Front Endocrinol (Lausanne),2021,11:555243.
［25］　REN H,LIU Z,LIU S,et al.Profile and clinical implication of circular RNAs in human papillary thyroid carcinoma［J］.Peer J,2018,6(1):e5363.
［26］　SUN D,CHEN L,LV H,et al.Circ_0058124 upregulates MAPK1 expression to promote proliferation,metastasis and metabolic abilities in thyroid cancer through sponging miR- 940 ［J］.Oncol Targets Ther,2020,13:1569-1581.
［27］　CHEN F,FENG Z,ZHU J,et al.Emerging roles of circRNA_NEK6 targeting miR-370-3p in the proliferation and invasion of thyroid cancer via Wnt signaling pathway［J］.Cancer Biol Ther,2018,19(12):1139-1152.
［28］　白超,杨雯雯,张丽.血清circRNA在PTMC及中央区颈部淋巴结转移的表达研究［J］.重庆医学,2020,49(21):3587-3591.
BAI C,YANG W W,ZHANG L.Expression of serum circRNA in papillary thyroid microcarcinom and central region cervical lymph node metastasis ［J］.Chongqing Med,2020,49(21):3587-3591.
［29］　JIN X,WANG Z,PANG W,et al.Upregulated hsa_circ_0004458 contributes to progression of papillary thyroid carcinoma by inhibition of miR-885-5p and activation of RAC1 ［J］.Med Sci Monit,2018,24:5488.
［30］　CAI X,ZHAO Z,DONG J,et al.Circular RNA circBACH2 plays a role in papillary thyroid carcinoma by sponging miR-139-5p and regulating LMO4 expression［J］.Cell Death Dis,2019,10(3):184.
［31］　李红光,赵利红,卢昂,等.环状RNA_0023990/微小RNA8735p/ANXA2对甲状腺癌放射敏感性的影响及机制研究［J］.中华医学杂志,2021,101(40):3329-3337.
LI H G,ZHAO L H,LU A,et al.The mechanism of circ_0023990/miR8735p/ANXA2 axis regulating radio sensitivity and development of thyroid carcinoma［J］.Natl Med J China,2021,101(40):3329-3337.
［32］　YANG C,HAN S J.The circular RNA circ0005654 interacts with specificity protein 1 via microRNA-363 sequestration to promote gastric cancer progression［J］.Bioengineered,2021,12(1):6305-6317.
［33］　DING" W,ZHAO S,SHI Y,et al.Positive feedback loop SP1/SNHG1/miR-199a-5p promotes the malignant properties of thyroid cancer［J］.Biochem Biophys Res Commun,2020,522(3):724-730.

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更新日期/Last Update: 2022-07-05