[1]孟军勤,董　男.舒肝解郁胶囊联合文拉法辛治疗绝经期抑郁症疗效观察[J].新乡医学院学报,2022,39(7):653-658.[doi:10.7683/xxyxyxb.2022.07.011]
　MENG Junqin,DONG Nan.Effect of venlafaxine combined with Shuganjieyu capsule in the treatment of menopausal depression[J].Journal of Xinxiang Medical University,2022,39(7):653-658.[doi:10.7683/xxyxyxb.2022.07.011]
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舒肝解郁胶囊联合文拉法辛治疗绝经期抑郁症疗效观察
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
39
期数:
2022年7
页码:
653-658
栏目:
临床研究
出版日期:
2022-07-05

文章信息/Info

Title:
Effect of venlafaxine combined with Shuganjieyu capsule in the treatment of menopausal depression
作者:
孟军勤; 董　男
（郑州市第八人民医院精神心理科，河南　郑州　450000）
Author(s):
MENG Junqin; DONG Nan
（Department of Psychiatric，the Eighth People′s Hospital of Zhengzhou，Zhengzhou 450000，Henan Province，China）
关键词:
绝经期; 抑郁症; 文拉法辛; 舒肝解郁胶囊; 生活质量; 神经递质; 不良反应
Keywords:
menopause; depression; venlafaxine; Shuganjieyu capsule; quality of life; neurotransmitter; adverse reaction
分类号:
R969
DOI:
10.7683/xxyxyxb.2022.07.011
文献标志码:
A
摘要:
目的　探讨舒肝解郁胶囊联合文拉法辛治疗绝经期抑郁症患者的疗效。方法　选择2019年6月至2020年10月郑州市第八人民医院收治的绝经期抑郁症患者130例为研究对象，根据治疗方法将患者分为对照组和观察组，每组65例。对照组患者给予盐酸文拉法辛缓释片口服，起始剂量为75 mg·d"-1，每日1次，结合患者实际情况盐酸文拉法辛缓释片剂量于2周内逐渐增加至150~225 mg·d-1，连续治疗8周。观察组患者在对照组基础上给予舒肝解郁胶囊口服，每次0.72 g，每日2次，连续治疗8周。分别于治疗前、后，采用汉密尔顿抑郁量表（HAMD）和贝克抑郁自评量表（BDI）评估2组患者的抑郁症状严重程度，采用生活质量量表（SF-36）评估2组患者的生活质量，使用脑涨落图仪检测2组患者脑内去甲肾上腺素（NE）、乙酰胆碱（Ach）、多巴胺（DA）、5-羟色胺（5-HT）、γ-氨基丁酸（GABA）实测功率（神经递质功能），采用全自动化学发光免疫分析法检测2组患者外周血中促黄体生成素（LH）、雌二醇（E2）、卵泡刺激素（FSH）、睾酮（T）水平。记录2组患者治疗期间嗜睡、口干、便秘、恶心等不良反应发生情况。结果　治疗前，2组患者的HAMD、BDI评分比较差异无统计学意义（P>0.05）；2组患者治疗后的HAMD、BDI评分均显著低于治疗前（P<0.05）；治疗后，观察组患者的HAMD、BDI评分均显著低于对照组（P<0.05）。治疗前，2组患者SF-36中8个维度评分比较差异无统计学意义（P>0.05）；2组患者治疗后SF-36中心理功能、总体健康、活力、社会功能、情感职能、精神健康维度评分均显著高于治疗前（P<0.05）；治疗后，观察组患者SF-36中心理功能、总体健康、活力、社会功能、情感职能、精神健康维度评分均显著高于对照组（P<0.05）。治疗前，2组患者的NE、Ach、DA、5-HT、GABA实测功率比较差异无统计学意义（P>0.05）；2组患者治疗后的NE、Ach、DA、5-HT、GABA实测功率均显著高于治疗前（P<0.05）；治疗后，观察组患者NE、Ach、DA、5-HT、GABA实测功率显著高于对照组（P<0.05）。治疗前，2组患者外周血中LH、E2、FSH、T水平比较差异无统计学意义（P>0.05）；对照组患者治疗后外周血中LH、E2、FSH、T水平与治疗前比较差异无统计学意义（P>0.05）；观察组患者治疗后外周血中T、FSH、LH水平显著低于治疗前，E2水平显著高于治疗前（P<0.05）；治疗后，观察组患者外周血中T、FSH、LH水平显著低于对照组，E2水平显著高于对照组（P<0.05）。治疗期间，对照组和观察组患者不良反应发生率分别为3.08%（2/65）和7.69%（6/65）；2组患者的不良反应发生率比较差异无统计学意义（χ2=2.131，P>0.05）。结论　舒肝解郁胶囊联合文拉法辛治疗能够减轻绝经期抑郁症患者抑郁症状，改善生活质量，调节神经递质功能与外周血激素水平，且安全性较高。
Abstract:
Objective　To investigate the effect of venlafaxine combined with Shuganjieyu capsule in the treatment of menopausal depression.Methods　A total of 130 patients with menopausal depression admitted to the Eighth People′s Hospital of Zhengzhou from June 2019 to October 2020 were selected as the research objects.According to the treatment methods,the patients were divided into the control group and the observation group,with 65 cases in each group.The patients in the control group were given venlafaxine hydrochloride sustained-release tablets,orally,with an initial dose of 75 mg·d-1,once a day,and the dose of venlafaxine hydrochloride sustained-release tablet gradually increased to 150-225 mg·d-1 within 2 weeks according to the actual conditions of the patients,the treatment was continuoused for 8 weeks.On the basis of the control group the patients in the observation group were given Shuganjieyu capsules orally,0.72 g each time,twice a day,the treatment was continuoused for 8 weeks.Before and after treatment,the severity of depressive symptoms of patients in the two groups was evaluated by the Hamilton depression scale (HAMD) and the Beck depression inventory (BDI);the quality of life of the patients in the two groups was evaluated by the short form 36 questionnaire (SF-36);the measured power (neurotransmitter function) of norepinephrine (NE),acetylcholine (Ach),dopamine (DA),5-hydroxytryptamine (5-HT),γ-aminobutyric acid (GABA) in brain of the patients in the two groups was detected by the encephalofluctuograph;the levels of luteinizing hormone (LH),estradiol (E2),follicle stimulating hormone (FSH),testosterone (T) in peripheral blood of patients in the two groups were detected by the fully automatic chemiluminescence immunoassay.The occurrence of adverse reactions such as drowsiness,dry mouth,constipation and nausea of patients in the two groups were recorded during treatment.Results　Before treatment,there was no significant difference in the HAMD and BDI scores of patients between the two groups (P>0.05);the HAMD and BDI scores of patients after treatment were significantly lower than those before treatment in the two groups (P<0.05);after treatment the HAMD and BDI scores of the patients in the observation group were significantly lower than those in the control group (P<0.05).Before treatment,there was no significant difference in the SF-36 scores of eight dimensions between the two groups (P>0.05);the SF-36 scores of psychological function,overall health,vitality,social function,emotional function and mental health dimensions of patients after treatment were significantly higher than those before treatment in the two groups (P<0.05);after treatment,the SF-36 scores of psychological function,overall health,vitality,social function,emotional function and mental health dimensions of patients in the observation group were significantly higher than those in the control group (P<0.05).Before treatment,there was no significant difference in the measured power of NE,Ach,DA,5-HT and GABA of patients between the two groups (P>0.05);the measured powers of NE,Ach,DA,5-HT,GABA of patients after treatment were significantly higher than those before treatment in the two groups (P<0.05);after treatment,the measured powers of NE,Ach,DA,5-HT and GABA of patients in the observation group were significantly higher than those in the control group (P<0.05).Before treatment,there was no significant difference in the levels of LH,E2,FSH and T in peripheral blood of patients between the two groups (P>0.05);there was no significant difference in the levels of LH,E2,FSH,T in peripheral blood of patients in the control group between before and after treatment(P>0.05);the levels of T,FSH and LH in peripheral blood of patients in the observation group after treatment were significantly lower than those before treatment,and the E2 level was significantly higher than that before treatment (P<0.05);after treatment,the levels of T,FSH and LH in peripheral blood of patients in the observation group were significantly lower than those in the control group,and the level of E2 was significantly higher than that in the control group (P<0.05).During the treatment,the incidence of adverse reactions in the control group and the observation group was 3.08% (2/65) and 7.69% (6/65),respectively;there was no significant difference in the incidence of adverse reactions of patients between the two groups (χ2=2.131,P>0.05).Conclusion　Shuganjieyu capsule combined with venlafaxine can relieve the symptoms of depression,improve the quality of life,regulate the function of neurotransmitters and the level peripheral blood hormones of menopausal depression patients,and has high safety.

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更新日期/Last Update: 2022-07-05