[1]冯思娜,舒星星,李笑雨,等.小胶质细胞介导慢性偏头痛的发病机制研究进展[J].新乡医学院学报,2022,39(3):296-300.[doi:10.7683/xxyxyxb.2022.03.019]
 FENG Sina,SHU Xingxing,LI Xiaoyu,et al.Research progress of microglia-mediated pathogenesis of chronic migraine[J].Journal of Xinxiang Medical University,2022,39(3):296-300.[doi:10.7683/xxyxyxb.2022.03.019]
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小胶质细胞介导慢性偏头痛的发病机制研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
39
期数:
2022年3
页码:
296-300
栏目:
综述
出版日期:
2022-03-05

文章信息/Info

Title:
Research progress of microglia-mediated pathogenesis of chronic migraine
作者:
冯思娜1舒星星1李笑雨1张 慧2
(1.陕西中医药大学,陕西 咸阳 712046;2.陕西中医药大学附属医院脑病医院一病区,陕西 咸阳 712000)
Author(s):
FENG Sina1SHU Xingxing1LI Xiaoyu1ZHANG Hui2
(1.Shaanxi University of Chinese Medicine,Xianyang 712046,Shaanxi Province,China;2.The First Ward of the Encephalopathy Hospital,Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,Shaanxi Province,China)
关键词:
慢性偏头痛小胶质细胞中枢敏化血小板二磷酸腺苷受体亚基12受体Ras同源基因家族成员A/Rho相关卷曲螺旋蛋白激酶通路
Keywords:
chronic migrainemicrogliacentral sensitizationplatelet adenosine diphosphate receptor subunit 12 receptorRas homolog gene familymember A/Rho-associated coiled-coil containing protein kinase
分类号:
R74
DOI:
10.7683/xxyxyxb.2022.03.019
文献标志码:
A
摘要:
小胶质细胞是中枢神经系统的免疫细胞,其活化后发生形态改变,释放多种促炎因子,参与中枢敏化并介导疼痛的发生。研究表明,血小板二磷酸腺苷受体亚基12受体-Ras同源基因家族成员A/Rho相关卷曲螺旋蛋白激酶信号通路与小胶质细胞活化及形态改变显著相关,并在慢性偏头痛的发生过程中发挥着至关重要的作用。本文就小胶质细胞在慢性偏头痛发生、发展过程中的作用机制进行综述。
Abstract:
Microglia are immune cells of the central nervous system,which undergo morphological changes after activation,release a variety of pro-inflammatory factors,participate in central sensitization and mediate the occurrence of pain.Studies have shown that platelet adenosine diphosphate receptor subunit 12 receptor-Ras homolog gene familymember A/Rho-associated coiled-coil containing protein kinase signaling pathway is significantly associated with microglial activation and morphological changes,and play a crucial role in the development of chronic migraine.This article reviews the mechanism of microglia in the occurrence and development of chronic migraine.

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更新日期/Last Update: 2022-03-05