[1]宋若愚,齐新文.动物负重长骨牵张成骨模型建立与评估研究进展[J].新乡医学院学报,2022,39(3):289-295.[doi:10.7683/xxyxyxb.2022.03.018]
 SONG Ruoyu,QI Xinwen.Research progress in establishment and evaluation of animal weight-bearing long bone distraction osteogenesis model[J].Journal of Xinxiang Medical University,2022,39(3):289-295.[doi:10.7683/xxyxyxb.2022.03.018]
点击复制

动物负重长骨牵张成骨模型建立与评估研究进展
分享到:

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
39
期数:
2022年3
页码:
289-295
栏目:
综述
出版日期:
2022-03-05

文章信息/Info

Title:
Research progress in establishment and evaluation of animal weight-bearing long bone distraction osteogenesis model
作者:
宋若愚齐新文
(遵义医科大学第五附属珠海医院骨二科,广东 珠海 519100)
Author(s):
SONG RuoyuQI Xinwen
(The Second Department of Orthopaedics,the Fifth Affiliated Hospital of Zunyi Medical University,Zhuhai 519100,Guangdong Province,China)
关键词:
牵张成骨负重长骨动物模型
Keywords:
distraction osteogenesisweight-bearing long bonesanimal model
分类号:
R681
DOI:
10.7683/xxyxyxb.2022.03.018
文献标志码:
A
摘要:
牵张成骨技术临床应用广泛,建立动物模型是研究牵张成骨作用机制和促进骨及软组织再生方案的有效途径。目前,动物负重长骨牵张成骨模型建立尚无统一标准,这限制了对牵张成骨作用机制的深入研究。本文就动物负重长骨牵张成骨模型的建立与评估方案进行综述,为进一步研究牵张成骨提供参考。
Abstract:
The distraction osteogenesis is widely used in clinic,the establishment of animal model is an effective way to study the mechanism of distraction osteogenesis and to promote bone and soft tissue regeneration.At present,there is no unified standard for the establishment of animal weight-bearing long bone distraction osteogenesis model,which limits the in-depth understanding of the mechanism of distraction osteogenesis.Therefore,this paper reviews the establishment and evaluation of animal weight-bearing long bone distraction osteogenesis model,in order to provide reference for further study of distraction osteogenesis.

参考文献/References:

[1] MORILLO C M R,SLONIAK M C,GONALVES F,et al.Efficacy of stem cells on bone consolidation of distraction osteogenesis in animal models:a systematic review [J].Braz Oral Res,2018,32:e83.
[2] 沈洁,叶晓健.“手风琴”技术在牵张成骨区新生骨矿化中的作用[J].中国修复重建外科杂志,2018,32(5):558-567.
SHEN J,YE X J.Effect of "accordion" technique on bone consolidation during distraction osteogenesis[J].Chin J Reparat Reconstr Surg,2018,32(5):558-567.
[3] DHALIWAL K,KUNCHUR R,FARHADIEH R.Review of the cellular and biological principles of distraction osteogenesis:an in vivo bioreactor tissue engineering model[J].J Plast Reconstr Aesthet Surg,2016,69(2):e19-e26.
[4] SUN Y X,ZHANG J F,XU J,et al.MicroRNA-144-3p inhibits bone formation in distraction osteogenesis through targeting Connexin 43[J].Oncotarget,2017,8(52):89913-89922.
[5] FUJIO M,OSAWA Y,MATSUSHITA M,et al.A mouse distraction osteogenesis model[J].J Vis Exp,2018,141:e57925.
[6] PITHIOUX M,ROSEREN F,JALAIN C,et al.An efficient and reproducible protocol for distraction osteogenesis in a rat model leading to a functional regenerated femur[J].J Vis Exp,2017,128:e56433.
[7] POBLOTH A M,SCHELL H,PETERSEN A,et al.Tubular open-porous β-tricalcium phosphate polycaprolactone scaffolds as guiding structure for segmental bone defect regeneration in a novel sheep model[J].J Tissue Eng Regen Med,2018,12(4):897-911.
[8] NIEMEYER F,CLAES L,IGNATIUS A,et al.Simulating lateral distraction osteogenesis[J].PLoS One,2018,13(3):e0194500.
[9] SCHUELKE J,MEYERS N,REITMAIER S,et al.Intramembranous bone formation after callus distraction is augmented by increasing axial compressive strain[J].PLoS One,2018,13(4):e0195466.
[10] HERNANDEZ-FERNANDEZ A,VELEZ R,SOLDADO F,et al.Effect of administration of platelet-rich plasma in early phases of distraction osteogenesis:an experimental study in an ovine femur model[J].Injury,2013,44(7):901-907.
[11] FLOERKEMEIER T,THOREY F,WELLMANN M,et al.αBSM failed as a carrier of rhBMP-2 to enhance bone consolidation in a sheep model of distraction osteogenesis[J].Acta Bioeng Biomech,2017,19(4):55-62.
[12] MORA-MACAS J,GIRLDEZ-SNCHEZ M ,LPEZ M,et al.Comparison of methods for assigning the material properties of the distraction callus in computational models[J].Int J Numer Method Biomed Eng,2019,35(9):e3227.
[13] LI W,ZHU S,HU J.Bone regeneration is promoted by orally administered bovine lactoferrin in a rabbit tibial distraction osteogenesis model[J].Clin Orthop Relat Res,2015,473(7):2383-2393.
[14] 汤丽国,任志勇,刘增运,等.自体富血小板血浆促进兔胫骨牵张成骨新骨形成的实验研究[J].实用手外科杂志,2020,34(3):335-337.
TANG L G,REN Z Y,LIU Z Y,et al,Experimental study of promoting osteogenesis of rabbit tibia in distraction osteogenesis by autologous platelet-rich plasma[J].J Pract Hand Surg,2020,34(3):335-337.
[15] MONTES-MEDINA L,HERNNDEZ-FERNNDEZ A,GUTIRREZ-RIVERA A,et al.Effect of bone marrow stromal cells in combination with biomaterials in early phases of distraction osteogenesis:an experimental study in a rabbit femur model[J].Injury,2018,49(11):1979-1986.
[16] OHATA T,MARUNO H,ICHIMURA S.Changes over time in callus formation caused by intermittently administering PTH in rabbit distraction osteogenesis models[J].J Orthop Surg Res,2015,10:88-96.
[17] MCDONALD M M,MORSE A,BIRKE O,et al.Sclerostin antibody enhances bone formation in a rat model of distraction osteogenesis[J].J Orthop Res,2018,36(4):1106-1113.
[18] WENG Z J,WANG C Y,ZHANG C,et al.All-trans retinoic acid promotes osteogenic differentiation and bone consolidation in a rat distraction osteogenesis model[J].Calcif Tissue Int,2019,104(3):320-330.
[19] YANG Y H,PAN Q,ZOU K J,et al.Administration of allogeneic mesenchymal stem cells in lengthening phase accelerates early bone consolidation in rat distraction osteogenesis model[J].Stem Cell Res Ther,2020,11(1):129-140.
[20] HAMUSHAN M,CAI W J,ZHANG Y B,et al.High-purity magnesium pin enhances bone consolidation in distraction osteogenesis model through activation of the VHL/HIF-1α/VEGF signaling[J].J Biomater Appl,2020,35(2):224-236.
[21] SHEN Z,LIN H X,CHEN G Q,et al.Comparison between the induced membrane technique and distraction osteogenesis in treating segmental bone defects:an experimental study in a rat model[J].PLoS One,2019,14(12):e0226839.
[22] FLURKEY K M,CURRER J,HARRISON D E.The mouse in biomedical research [M].2nd ed.Burlington:Academic Press,2007:637-672.
[23] AHO O M,LEHENKARI P,RISTINIEMI J,et al.The mechanism of action of induced membranes in bone repair[J].J Bone Joint Surg Am,2013,95(7):597-604.
[24] WEN G,XU J,WU T Y,et al.Functionalized polycaprolactone/hydroxyapatite composite microspheres for promoting bone consolidation in a rat distraction osteogenesis model[J].J Orthop Res,2020,38(5):961-971.
[25] HUSSEINI A,ST-ARNAUD R.CYP24A1-deficiency does not affect bone regeneration in distraction osteogenesis[J].J Steroid Biochem Mol Biol,2017,173:168-172.
[26] OSAWA Y,MATSUSHITA M,HASEGAWA S,et al.Activated FGFR3 promotes bone formation via accelerating endochondral ossification in mouse model of distraction osteogenesis[J].Bone,2017,105:42-49.
[27] WAHL E C,ARONSON J,LIU L,et al.Metabolic endotoxemia and inhibition of direct bone regeneration:a pilot study[J].Br J Med & Med Res,2012,2(4):510-519.
[28] LYBRAND K,BRAGDON B,GERSTENFELD L.Mouse models of bone healing:fracture,marrow ablation,and distraction osteogenesis[J].Curr Protoc Mouse Biol,2015,5(1):35-49.
[29] 孙丙银,朱洁英,熊建尉,等.牵张成骨模型兔的建立与评估[J].中国组织工程研究,2017,(16):2576-2581.
SUN B Y,ZHU J Y,XIONG J W,et al.Establishment and evaluation of a rabbit model of distraction osteogenesis[J].Chin J Tissue Eng Res,2017,(16):2576-2581.
[30] TSUCHIYA H,SAKURAKICHI K,YAMASHIRO T,et al.Bone transport with frozen devitalized bone:an experimental study using rabbits and a clinical application[J].J Orthop Sci,2004,9(6):619-624.
[31] DEHGHAN M M,ESLAMINEJAD M B,MOTALLEBIZADEH N,et al.Transplantation of autologous bone marrow mesenchymal stem cells with platelet-rich plasma accelerate distraction osteogenesis in a canine model [J].Cell J,2015,17(2):243-252.
[32] MILLER D L,GOSWAMI T.A review of locking compression plate biomechanics and their advantages as internal fixators in fracture healing[J].Clin Biomech,2007,22(10):1049-1062.
[33] XU J,SUN Y X,WU T Y,et al.Enhancement of bone regeneration with the accordion technique via HIF-1α/VEGF activation in a rat distraction osteogenesis model[J].J Tissue Eng Regen Med,2018,12(2):e1268-e1276.
[34] SAILHAN F,CHOTEL F,CHUSTA A,et al.Effects of RH-BMP-7 on bone healing in a rabbit model of distraction-induced osteogenesis[J].Proc Soc Exp Biol Med,2008,126(1):161-166.
[35] KIM J B,LEE D Y,SEO S G,et al.Demineralized bone matrix injection in consolidation phase enhances bone regeneration in distraction osteogenesis via endochondral bone formation[J].Clin Orthop Surg,2015,7(3):383-391.
[36] ZDEL A,SARISZEN B,YALCINKAYA U,et al.The effect of HIF stabilizer on distraction osteogenesis[J].Acta Orthop Traumatol Turc,2015,49(1):80-84.
[37] 曾景奇,黄枫,姜自伟,等.一种牵张成骨大鼠实验模型的建立[J].中国实验动物学报,2016,24(1):43-46.
ZENG J Q,HUANG F,JIANG Z W,et al.Establishment of a novel rat model of distraction osteogenesis[J].Acta Lab Anim Sci Sin,2016,24(1):43-46.
[38] FLOERKEMEIER T,THOREY F,WELLMANN M,et al.rhBMP-2 in an injectable gelfoam carrier enhances consolidation of the distracted callus in a sheep model[J].Technol Health Care,2017,25(6):1163-1172.
[39] BRAGDON B,LYBRAND K,GERSTENFELD L.Overview of biological mechanisms and applications of three murine models of bone repair:closed fracture with intramedullary fixation,distraction osteogenesis,and marrow ablation by reaming[J].Curr Protoc Mouse Biol,2015,5(1):21-34.
[40] WEISS S,BAUMGART R,JOCHUM M,et al.Systemic regulation of distraction osteogenesis:a cascade of biochemical factors[J].J Bone Miner Res,2002,17(7),1280-1289.
[41] KITOH H,KITAKOJI T,TSUCHIYA H,et al.Transplantation of marrow-derived mesenchymal stem cells and platelet-rich plasma during distraction osteogenesis-a preliminary result of three cases[J].Bone,2004,35(4):892-898.
[42] LI G,VIRDI A S,ASHHURST D E,et al.Tissues formed during distraction osteogenesis in the rabbit are determined by the distraction rate:localization of the cells that express the mRNAs and the distribution of typesⅠandⅡcollagens[J].Cell Biol Int,2000,24(1):25-33.
[43] CURRAN A R,KUO K N,LUBICKY J P.Simultaneous ipsilateral femoral and tibial lengthening with the Ilizarov method[J].J Pediatr Orthop,1999,19(3):386-390.
[44] GDALEVITCH M,KASAAI B,ALAM N,et al.The effect of heparan sulfate application on bone formation during distraction osteogenesis[J].PLoS One,2013,8(2):e56790.
[45] FLOERKEMEIER T,HURSCHLER C,WITTE F,et al.Callus tissue torsional,bending and compressive stiffness are interrelated and predict the bone load bearing capacity in a model of distraction osteogenesis[J].Orthop Proc,2006,90 (2):348.
[46] MEYERS N,IGNATIUS A,CLAES L,et al.Novel systems for the application of isolated tensile,compressive,and shearing stimulation of distraction callus tissue[J].PLoS One,2017,12(12):e0189432.
[47] MISHIMA K,KITOH H,OHKAWARA B,et al.Lansoprazole upregulates polyubiquitination of the TNF receptor-associated factor 6 and facilitates Runx2-mediated osteoblastogenesis[J].EBioMedicine,2015,2(12):2046-2061.

更新日期/Last Update: 2022-03-05