[1]齐玉敏.新生儿嗜酸性粒细胞增多症危险因素分析[J].新乡医学院学报,2022,39(1):081-84.[doi:10.7683/xxyxyxb.2022.01.017]
 QI Yumin.Analysis of the risk factors for neonatal eosinophilia[J].Journal of Xinxiang Medical University,2022,39(1):081-84.[doi:10.7683/xxyxyxb.2022.01.017]
点击复制

新生儿嗜酸性粒细胞增多症危险因素分析
分享到:

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
39
期数:
2022年1
页码:
081-84
栏目:
临床研究
出版日期:
2022-01-05

文章信息/Info

Title:
Analysis of the risk factors for neonatal eosinophilia
作者:
齐玉敏
(南阳市中心医院新生儿科,河南 南阳 473000)
Author(s):
QI Yumin
(Department of Neonatology,Nanyang Central Hospital,Nanyang 473000,Henan Province,China)
关键词:
新生儿嗜酸性粒细胞增多症危险因素
Keywords:
newborneosinophiliarisk factor
分类号:
R722
DOI:
10.7683/xxyxyxb.2022.01.017
文献标志码:
A
摘要:
目的 探讨新生儿嗜酸性粒细胞增多症的危险因素,为防治新生儿嗜酸性粒细胞增多症提供依据。方法 选择2019年2月至2020年8月于南阳市中心医院出生的600名新生儿及其母亲为研究对象。通过临床病历资料和一般资料调查表采集新生儿及其母亲的临床资料,新生儿资料包括性别、出生胎龄、出生体质量、宫内窒息、宫内感染等,母亲资料包括年龄、分娩方式、妊娠期糖尿病、妊娠期高血压、胎膜早破、羊水污染、前置胎盘、促红细胞生成素使用、解脲脲原体感染等。应用全自动血细胞分析仪于新生儿出生第4、6周检测嗜酸性粒细胞水平以判断有无嗜酸性粒细胞增多症;采用单因素、多因素logistic回归分析嗜酸性粒细胞增多症的危险因素,对新生儿嗜酸性粒细胞增多症与危险因素的相关性进行Spearman相关性分析。结果 600名新生儿中,发生嗜酸性粒细胞增多症76例(嗜酸性粒细胞增多症组),未发生嗜酸性粒细胞增多症524例(正常组),嗜酸性粒细胞增多症发生率为12.67%(76/600)。单因素分析结果显示,新生儿嗜酸性粒细胞增多症与出生胎龄、出生体质量、母亲解脲脲原体感染、母亲使用促红细胞生成素有关(P<0.05),与新生儿性别、母亲年龄、分娩方式、妊娠期糖尿病、宫内感染、胎膜早破、羊水污染、前置胎盘、宫内窒息、妊娠期高血压无关(P>0.05)。多因素logistic回归分析结果显示,出生胎龄、出生体质量、母亲解脲脲原体感染、母亲使用促红细胞生成素是新生儿发生嗜酸性粒细胞增多症的独立危险因素(P<0.05)。Spearman相关性分析结果显示,新生儿嗜酸性粒细胞增多症与出生胎龄、出生体质量呈显著负相关(r=-0.734、-0.691,P<0.05),与促红细胞生成素使用、解脲脲原体感染呈显著正相关(r=0.826、0.858,P<0.05)。结论 新生儿嗜酸性粒细胞增多症的发生率较高,出生胎龄、出生体质量、母亲使用促红细胞生成素、母亲解脲脲原体感染是新生儿发生嗜酸性粒细胞增多症的独立危险因素。
Abstract:
Objective To investigate the risk factors for neonatal eosinophilia,so as to provide basis for the prevention and treatment of neonatal eosinophilia.Methods A total of 600 newborns born in Nanyang Central Hospital from February 2019 to August 2020 and their mothers were selected as the research subjects.The clinical data of newborns and their mothers were collected through clinical medical records and general data questionnaire.The data of newborn included gender,birth age,birth mass,intrauterine asphyxia,intrauterine infection and so on.The data of the mothers included age,delivery mode,gestational diabetes mellitus,gestational hypertension,premature rupture of membranes,amniotic fluid contamination,placenta previa,using erythropoietin and Ureaplasma urealyticum infection.The level of eosinophils was detected by automatic blood cell analyzer at the 4th and 6th weeks of birth to judge whether there was eosinophilia.The risk factors for eosinophilia were analyzed by univariate and multivariate logistic regression.The correlation between neonatal eosinophilia and risk factors was analyzed by Spearman correlation analysis.Results Among the 600 newborns,76 cases had eosinophilia (eosinophilia group) and 524 cases had no eosinophilia (normal group),the incidence of eosinophilia was 12.67% (76/600).The univariate analysis showed that the neonatal eosinophilia was related to the gestational age,birth mass,Ureaplasma urealyticum infection and using erythropoietin of mothers (P<0.05),but it was not related to the gender,age,delivery mode,gestational diabetes mellitus,intrauterine infection,premature rupture of membranes,amniotic fluid contamination,placenta previa,intrauterine asphyxia and gestational hypertension (P>0.05).The multivariate logistic regression analysis showed that the gestational age,birth mass,Ureaplasma urealyticum infection and using erythropoietin of mothers were the independent risk factors for neonatal eosinophilia (P<0.05).The Spearman correlation analysis showed that the neonatal eosinophilia was negatively correlated with the birth age and birth weight (r=-0.734,-0.691P<0.05),but it was positively correlated with the using erythropoietin and Ureaplasma urealyticum infection of mothers(r=0.826,0.858P<0.05).Conclusion The incidence of neonatal eosinophilia is high.The gestational age,birth mass,maternal using erythropoietin and Ureaplasma urealyticum infection are the independent risk factors for neonatal eosinophilia.

参考文献/References:

[1] KLION A D,ACKERMAN S J,BOCHNER B S.Contributions of eosinophils to human health and disease[J].Annu Rev Pathol,2020,24(15):179-209.
[2] 张萨丽,徐传辉,穆荣.2012年版嗜酸性粒细胞增多症及相关综合征分类标准的共识[J].中华风湿病学杂志,2013,17(1):58-59.
ZHANG S L,XU C H,MU R.Consensus on classification criteria of eosinophilia and related syndromes(2012 edition)[J].Chin J Rheumatol,2013,17(1):58-59.
[3] RIMSZA L,CRAIG F E,REICHARD K K,et al.Addressing the challenges of eosinophilia and mastocytosis[J].Am J Clin Pathol,2021,155(2):156-159.
[4] SCHUSTER B,ZINK A,EYERICH K.Medical algorithm:diagnosis and treatment of hypereosinophilic syndrome[J].Allergy,2020,75(11):3003-3006.
[5] SULLIVAN S E,CALHOUN D A.Eosinophilia in the neonatal intensive care unit[J].Clin Perinatol,2000,27(3):603-622.
[6] YEN J M,LIN C H,YANG M M,et al.Eosinophilia in very low birth weight infants[J].Pediatr Neonatol,2010,51(2):116-123.
[7] LPEZ-HURTADO M,ARTEAGA-TRONCOSO G,SOSA-GONZLEZ I E,et al.Eosinophilia in preterm born infants infected with chlamydia trachomatis[J].Fetal Pediatr Pathol,2016,35(3):149-158.
[8] LUTFI S A,MAHMAH M A,ALBURAKI W,et al.The value of blood eosinophils count in infants with feeding intolerance in the neonatal intensive care setting[J].J Perinat Med,2012,5(1):17-23.
[9] LEE W T,HUNG C H,CHEN H L,et al.Eosinophilia in hospitalized newborn infants[J].Clin Neonatol,2008,15(1):16-19.
[10] YEN J M,LIN C H,YANG M M,et al.Eosinophilia in very low birth weight infants[J].Pediatr Neonatol,2010,51(2):116-123.
[11] 郑淮武,万胜明,邱素清.解脲支原体与新生儿疾病关系的研究进展[J].中国新生儿科杂志,2019,34(3):234-238.
ZHENG H W,WAN S M,QIU S Q.Research progress on the relationship between Ureaplasma urealyticum and neonatal diseases[J].Chin J Neonatol,2019,34(03):234-238.
[12] 明丹花.早产儿早期嗜酸性粒细胞增多的临床研究[D].广州:南方医科大学,2020.
MING D H.The clinical study of eosinophilia in premature infants during the early postnatal period[J].Guangzhou:Southern Medical University,2020.
[13] 罗蓓,童笑梅.围生期解脲脲原体感染的研究进展[J].中国儿童保健杂志,2019,27(6):620-623.
LUO B,TONG X M.Research progress on perinatal Ureaplasma urealyticum infection[J].Chin J Child Health Care,2019,27(6):620-623.
[14] SPRONG K E,MABENGE M,WRIGHT C A,et al.Ureaplasma species and preterm birth:current perspectives[J].Crit Rev Microbiol,2020,46(2):169-181.
[15] 张洁,吴敏,陈旭日.解脲支原体感染与胎膜早破及其不良妊娠结局的关系研究[J].中国医学创新,2020,17(1):54-57.
ZHANG J,WU M,CHEN S R.Relationship between Ureaplasma urealyticum infection and premature rupture of membranes and adverse pregnancy outcomes[J].Med Innovat Chin,2020,17(1):54-57.
[16] VITTORI D C,CHAMORRO M E,HERNNDEZ Y V,et al.Erythropoietin and derivatives:potential beneficial effects on the brain[J].J Neurochem,2021,158(5):1032-1057.
[17] MITTAL A,SINGH V,CHOWDHARY S,et al.The effect of recombinant human erythropoietin on bacterial growth:a dual-edged sword[J].Kidney Dis,2019,5(2):81-90.
[18] EHARA A,TAKEDA Y,KIDA T,et al.Time-course changes of eosinophil counts in premature infants:no effects of medical manipulation,except erythropoietin treatment,on eosinophilia[J].Pediatr Int,2000,42(1):58-60.

相似文献/References:

[1]刘素琴,徐晓群,徐苏东,等.妊娠期肝内胆汁淤积症对新生儿相关疾病发生情况的影响[J].新乡医学院学报,,():000.
[2]高锦荣,田玉慧,李万里,等.4659例新生儿出生体重的调查分析[J].新乡医学院学报,1986,3(03):017.
[3]冀玉英,冯淑英,王光松,等.新生儿败血症78例临床分析[J].新乡医学院学报,1987,4(03):052.
[4]于贵珍,杨平.新生儿溺入粪缸30分钟抢救成活一例[J].新乡医学院学报,1988,5(02):084.
[5]钱惠茵,李俊英,朱风华,等.347例新生儿死亡原因分析[J].新乡医学院学报,1989,6(02):109.
[6]陈莹,支凌翔,刘根生,等.新生儿胃肠道穿孔[J].新乡医学院学报,1994,11(03):294.
[7]杨立俭,田玉慧,高锦荣,等.分娩孕妇全血头发及新生儿脐血羊水中锌铜铁硒含量的研究[J].新乡医学院学报,1995,12(01):009.
[8]路永新,申素芳,赵润清,等.新生儿窒息的ABCDE复苏方案与预后[J].新乡医学院学报,1997,14(03):290.
[9]段金云,王柏霞.高危新生儿早期监测治疗[J].新乡医学院学报,1997,14(03):299.
[10]杨广平,州玉荣,王振西,等.5166例新生儿出生情况分析[J].新乡医学院学报,2001,18(06):439.

更新日期/Last Update: 2022-01-05