[1]张伟莉.超声表现联合Ki-67指数评估胃肠间质肿瘤恶性程度的价值[J].新乡医学院学报,2021,38(10):966-969.[doi:10.7683/xxyxyxb.2021.10.014]
　ZHANG Weili.Value of ultrasonography combined with Ki-67 index in evaluating the malignant degree of gastrointestinal stromal tumors[J].Journal of Xinxiang Medical University,2021,38(10):966-969.[doi:10.7683/xxyxyxb.2021.10.014]
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超声表现联合Ki-67指数评估胃肠间质肿瘤恶性程度的价值
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
38
期数:
2021年10
页码:
966-969
栏目:
临床研究
出版日期:
2021-10-05

文章信息/Info

Title:
Value of ultrasonography combined with Ki-67 index in evaluating the malignant degree of gastrointestinal stromal tumors
作者:
张伟莉
（亳州市人民医院超声科，安徽　亳州　236800）
Author(s):
ZHANG Weili
（Department of Ultrasound,Bozhou People′s Hospital,Bozhou 236800，Anhui Province,China）
关键词:
胃肠道间质瘤; 超声; Ki-67
Keywords:
gastrointestinal stromal tumor; ultrasound; Ki-67
分类号:
R735
DOI:
10.7683/xxyxyxb.2021.10.014
文献标志码:
A
摘要:
目的　探讨超声表现联合Ki-67指数评估胃肠道间质瘤(GIST)恶性程度的价值。方法　回顾性分析2018年1月至2020年12月于亳州市人民医院超声科经术后病理及免疫组织化学确诊的86例GIST患者的临床资料，分析GIST超声表现与Ki-67的表达是否能作为联合评估GIST恶性程度的标准，并验证Ki-67表达与GIST美国国立卫生研究院(NIH)危险度分级是否一致。结果　胃肠道内肿瘤与胃肠道外肿瘤患者的Ki-67表达分布的构成比比较差异有统计学意义（χ2=19.170,P=0.000）。Ki-67高表达患者的肿瘤长径（LD）显著高于极低表达、低表达、中表达患者 (P<0.05)；Ki-67极低表达、低表达、中表达患者的肿瘤LD比较差异无统计学意义(P>0.05)。Ki-67极低表达、低表达、中表达、高表达患者的肿瘤长径与短径（SD）的比值比较差异均无统计学意义（P>0.05）。GIST边缘不规则与边缘光滑患者Ki-67表达分布的构成比比较差异有统计学意义（P<0.05）。GIST内部回声不均匀与回声均匀患者Ki-67表达分布的构成比比较差异有统计学意义（P<0.05）。GIST内部回声低回声、中等回声及高回声患者Ki-67表达分布构成比比较差异无统计学意义（P>0.05）。超声表现联合Ki-67指数诊断GIST的曲线下面积大于单纯的超声检查或Ki-67指数（P<0.05）。GIST患者的Ki-67表达分级与NIH危险度分级具有一致性（Kappa=0.415，P<0.05）。结论　超声表现联合Ki-67指数评估GIST恶性程度的准确性较高。
Abstract:
Objective　To investigate the value of ultrasonography combined with Ki-67 index in evaluating the malignant degree of gastrointestinal stromal tumor (GIST).Methods　The clinical data of 86 patients with GIST diagnosed by postoperative pathology and immunohistochemistry in the Department of Ultrasound of Bozhou People′s Hospital from January 2018 to December 2020 were analyzed retrospectively，whether the combination of ultrasonic manifestations of GIST and the expression of Ki-67 could be used as the standard for evaluation the malignant degree of GIST was analyzed,and whether the Ki-67 expression was consistent with National Institutes of Health （NIH） risk grade was verified.Results　There was significant difference in the distribution of constituent ratio of Ki-67 expression between patients with gastrointestinal tumors and extragastrointestinal tumors (χ2=19.170,P=0.000).The tumor length diameter (LD) of patients with high expression of Ki-67 was significantly higher than that of patients with very low expression,low expression and medium expression of Ki-67 (P<0.05);there was no significant difference in tumor LD among patients with very low expression,low expression and medium expression of Ki-67 (P>0.05).There was no significant difference in the ratio of long diameter to short diameter (SD) among patients with very low expression,low expression,medium expression and high expression of Ki-67 (P>0.05).There was significant difference in the distribution of constituent ratio of Ki-67 expression between the patients with irregular margins and regular margins of GIST(P<0.05).There was significant difference in the distribution of constituent ratio of Ki-67 expression between the patients with uneven internal echo and uniform echo of GIST(P<0.05).There was no significant difference in the distribution of constituent ratio of Ki-67 expression among patients with lower echo,medium echo and high echo of GIST (P>0.05).The area under cure of GIST diagnosed by ultrasound combined with Ki-67 index was greater than that by ultrasonography alone or Ki-67 index (P<0.05).The area under curve of endoscopic ultrasonography guided fine needle aspiration combined with Ki-67 index in diagnosing GIST was higher than that of ultrasonography alone or Ki-67 index (P<0.05).The grade of Ki-67 expression was consistent with the risk grade of NIH in GIST patients (Kappa=0.415,P<0.05).Conclusion　Ultrasound combined with Ki-67 index is more accurate in evaluating the malignancy of GIST.

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更新日期/Last Update: 2021-10-05