[1]张婷婷,杨　君,王慧玲.血清维生素D和C-反应蛋白水平与多囊卵巢综合征发病的相关性分析[J].新乡医学院学报,2021,38(10):949-952.[doi:10.7683/xxyxyxb.2021.10.010]
　ZHANG Tingting,YANG Jun,WANG Huiling.Correlation analysis of serum vitamin D and C-reactive protein levels with polycystic ovary syndrome[J].Journal of Xinxiang Medical University,2021,38(10):949-952.[doi:10.7683/xxyxyxb.2021.10.010]
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血清维生素D和C-反应蛋白水平与多囊卵巢综合征发病的相关性分析
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
38
期数:
2021年10
页码:
949-952
栏目:
临床研究
出版日期:
2021-10-05

文章信息/Info

Title:
Correlation analysis of serum vitamin D and C-reactive protein levels with polycystic ovary syndrome
作者:
张婷婷; 杨　君; 王慧玲
（新乡医学院第一附属医院妇科二病区,河南　卫辉　453100）
Author(s):
ZHANG Tingting; YANG Jun; WANG Huiling
(Department of Gynecology,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,Henan Province,China)
关键词:
多囊卵巢综合征; 维生素D; C反应蛋白; 性激素6项
Keywords:
polycystic ovarian syndrome; vitamin D; C-reactive protein; sex hormone
分类号:
R711.75
DOI:
10.7683/xxyxyxb.2021.10.010
文献标志码:
A
摘要:
目的　探讨血清维生素D、C-反应蛋白（CRP）水平与多囊卵巢综合征（PCOS）发病的关系。方法　选择2018年10月至2019年10月新乡医学院第一附属医院收治的43例PCOS患者为研究对象,并选择同期体检健康女性40例为对照组,于月经来潮3~5 d采集2组受试者清晨空腹静脉血10 mL,分离血清,采用透射比浊法检测血清CRP水平,电化学发光免疫法测定血清雌二醇（E2）、卵泡生成素（FSH）、促黄体生成素（LH）、泌乳素（PRL）、黄体酮（PROG）、睾酮（TES）及25-羟维生素D［25-(OH)D］水平,比较2组受试者血清25-(OH)D、CRP、E2、FSH、LH、PRL、PROG、TES水平的差异,采用Pearson相关性分析25-(OH)D与CRP的关系及25-(OH)D、CRP与性激素6项的关系。结果　PCOS组患者血清25-(OH)D水平显著低于对照组(P<0.05),CRP、E2、FSH、TES水平显著高于对照组(P＜0.05)；PCOS组患者血清LH、PRL、PROG水平与对照组比较差异无统计学意义（P＞0.05）。Pearson相关性分析显示,PCOS组患者血清25-(OH)D水平与CRP、E2、FSH、LH及TES呈负相关（r=-0.608、-0.301、-0.288、-0.327、-0.479,P＜0.05）,与PRL、PROG无相关性（r=-0.167、0.051,P＞0.05）；PCOS组患者血清CRP水平与E2、FSH及TES呈正相关（r=0.267、0.466、0.543,P＜0.05）,与LH、PRL及PROG无相关性（r=0.203、0.068、0.130,P＞0.05）。结论　PCOS患者存在血清维生素D水平降低和CRP水平增高,维生素D在PCOS患者的疾病进展中发挥正向调节作用,CRP在PCOS患者的疾病进展中发挥负向调节作用,适当补充维生素D可能有助于控制PCOS患者的病情进展。
Abstract:
Objective　To investigate the relationship between serum vitamin D,C-reactive protein (CRP) levels and the onset of polycystic ovary syndrome (PCOS) .Methods　A total of 43 PCOS patients admitted to the First Affiliated Hospital of Xinxiang Medical University from October 2018 to October 2019 were selected as the research objects,40 healthy women who had physical examinations during the same period were selected as the control group.The 10 mL fasting venous blood in the early morning within 3 to 5 days of menstrual cramps of the subjects in the two groups were collected,the serum was separated,the serum CRP level was measured by turbidimetric method,and the estradiol (E2),follicle-forming hormone (FSH),luteinizing hormone (LH),prolactin (PRL),progesterone (PROG),testosterone(TES) and serum 25-hydroxyvitamin D ［25-(OH)D］ levels were determined by electrochemiluminescence immunoassay,the difference in the serum 25-( OH)D,CRP,E2,FSH,LH,PRL,PROG,TES level were compared between the two groups,Pearson correlation was used to analyze the relationship between 25-(OH)D and CRP and 25-(OH)D,CRP and sex hormones relation.Results　The serum 25-(OH)D level of patients in the PCOS group was significantly lower than that in the control group (P<0.05),and the levels of CRP,E2,FSH and TES were significantly higher than those in the control group (P<0.05).There was no significant difference in serum LH,PRL and PROG levels between the PCOS group and control group (P＞0.05).Pearson correlation analysis showed that serum 25-(OH)D levels were negatively correlated with CRP,E2,FSH,LH and TES in the PCOS group (r=-0.608,-0.301,-0.288,-0.327,-0.479;P<0.05),not correlated with PRL and PROG (r=-0.167,0.051;P>0.05);in PCOS group,the serum CRP levels were positively correlated with E2,FSH and TES (r=0.267,0.466,0.543;P<0.05),not correlated with LH,PRL and PROG (r=0.203,0.068,0.130;P>0.05).Conclusion　PCOS patients have decreased serum vitamin D levels and increased CRP levels.Vitamin D plays a positive regulatory role in the disease progression of PCOS patients,and CRP plays a negative regulatory role in the disease progression of PCOS patients.Appropriate vitamin D supplementation may help to control the progression of PCOS patients.

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更新日期/Last Update: 2021-10-05