[1]吕文豪,董 媛,魏子白.二甲双胍在结直肠癌治疗中的作用研究进展[J].新乡医学院学报,2021,38(7):692-695.[doi:10.7683/xxyxyxb.2021.07.020]
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二甲双胍在结直肠癌治疗中的作用研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
38
期数:
2021年7
页码:
692-695
栏目:
综述
出版日期:
2021-07-05

文章信息/Info

作者:
吕文豪董 媛魏子白
(长治医学院附属和平医院消化科,山西 长治 046000)
关键词:
二甲双胍结直肠癌2型糖尿病作用机制
分类号:
R735.3
DOI:
10.7683/xxyxyxb.2021.07.020
文献标志码:
A
摘要:
结直肠癌在2型糖尿病患者中的发病率较高。胰岛素、磺酰脲类、二肽基肽酶Ⅳ抑制剂和胰高血糖素样肽-1类似物等抗糖尿病药物,增加了糖尿病患者罹患癌症的风险。二甲双胍作为抗糖尿病药物,在糖尿病患者癌症防治方面显示出有益的效果。二甲双胍具有多种药理作用,主要是由于其可调控细胞凋亡、自噬、细胞周期、氧化应激、炎症反应、代谢稳态和表观遗传。本文就二甲双胍在抗结直肠癌临床研究中的进展及其潜在的作用机制进行综述。

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更新日期/Last Update: 2021-07-05