[1]王燕茹,卢德露,陈永林.同源盒基因转录反义RNA在卵巢上皮性恶性肿瘤中的作用研究进展[J].新乡医学院学报,2021,38(4):396-400.[doi:10.7683/xxyxyxb.2021.04.022]
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同源盒基因转录反义RNA在卵巢上皮性恶性肿瘤中的作用研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
38
期数:
2021年4
页码:
396-400
栏目:
综述
出版日期:
2021-04-05

文章信息/Info

作者:
王燕茹1卢德露1陈永林2
(1.兰州大学第一临床医学院,甘肃 兰州 370000;2.兰州大学第一医院病理科,甘肃 兰州 370000)
关键词:
长链非编码RNA同源基因转录反义RNA卵巢上皮性恶性肿瘤
分类号:
R737.31
DOI:
10.7683/xxyxyxb.2021.04.022
文献标志码:
A
摘要:
卵巢上皮性恶性肿瘤是女性生殖系统常见的恶性肿瘤之一,其病死率居妇科恶性肿瘤之首。约10%的卵巢癌与遗传基因的突变有关,其中以BRCA1/2基因突变研究最为深入,但卵巢癌的发生是一个多因素、多基因、多阶段的复杂的生物学过程,其病因及发生机制尚未明确。同源基因转录反义RNA(HOTAIR)是第1个被发现具有反式调节作用的长链非编码RNA,在维持肿瘤细胞的生长和增殖,提高肿瘤细胞的侵袭转移能力,诱导血管生成同时抑制肿瘤细胞的凋亡等方面具有重要意义;在卵巢癌的发病、转移、复发及肿瘤耐药中起到重要作用。本文对HOTAIR异常表达在卵巢上皮性恶性肿瘤发生、发展中的作用机制及其应用于临床的研究价值进行综述。

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更新日期/Last Update: 2021-04-05