[1]卢　娜,李　晓,刘冬玲,等.线粒体DNA氧化损伤在动脉粥样硬化发生、发展中的作用研究进展[J].新乡医学院学报,2021,38(3):201-206.[doi:10.7683/xxyxyxb.2021.03.001]
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线粒体DNA氧化损伤在动脉粥样硬化发生、发展中的作用研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
38
期数:
2021年3
页码:
201-206
栏目:
专题报告
出版日期:
2021-03-05

文章信息/Info

作者:
卢　娜; 李　晓; 刘冬玲; 王现伟
(新乡医学院基础医学院，河南省医用组织再生重点实验室，河南　新乡　453003)
关键词:
氧化损伤; 线粒体DNA; 动脉粥样硬化
分类号:
R364.3
DOI:
10.7683/xxyxyxb.2021.03.001
文献标志码:
A
摘要:
细胞受损可使线粒体（MT）产生过量活性氧（ROS），引起氧化应激水平升高，而ROS又可反作用于MT，造成线粒体DNA（mtDNA）损伤。动脉粥样硬化（AS）是一种以脂质累积、血管平滑肌细胞增生、细胞凋亡和局部炎症反应为特征的慢性炎症性疾病，氧化损伤是其发病机制之一。mtDNA氧化损伤可通过炎症反应、细胞凋亡和改变脂质代谢等途径促进AS的发生和发展。本文就mtDNA氧化损伤与AS的关系进行阐述，以期为AS的防治提供新的策略和靶点。

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更新日期/Last Update: 2021-03-05