[1]王淑贤,宋振峰,武林威,等.肌腱再生工程中肌腱细胞增殖分化研究进展[J].新乡医学院学报,2021,38(2):197-200.[doi:10.7683/xxyxyxb.2021.02.022]
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肌腱再生工程中肌腱细胞增殖分化研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
38
期数:
2021年2
页码:
197-200
栏目:
综述
出版日期:
2021-02-05

文章信息/Info

作者:
王淑贤1; 2; 宋振峰1; 武林威1; 任天宁1; 孙永琨1; 3
(1.新乡医学院基础医学院，河南　新乡　453003；2.新乡医学院三全学院，河南　新乡　453003；3.河南省医用组织再生重点实验室，河南　新乡　453003)
关键词:
肌腱再生; 组织工程; 增殖分化
分类号:
R686
DOI:
10.7683/xxyxyxb.2021.02.022
文献标志码:
A
摘要:
肌腱病变通常伴随着肌腱细胞的随意增生及变性，并出现胶原纤维断裂和非胶原基质产生过多的现象，其本质是一种不正常的愈合反应，但肌腱组织生长发育和损伤修复涉及的机制尚不清楚。随着我国民众运动意识的提高和老龄化进程的加剧，损伤性和退行性肌腱病的发病率也随之升高，临床常用的治疗方案如手术缝合、肌腱移植、保守治疗等无法保证肌腱功能完全恢复，亦有发生肌腱二次损伤的风险。近年来，用组织工程方法构建再生肌腱来修复损伤肌腱的研究日渐受到关注，而肌腱再生的关键是探明肌腱细胞生长相关的生物力学因素及分子机制，肌腱再生工程中如何选取理想的种子细胞、怎样进行有效的细胞培养尚存在争议。为了使损伤性肌腱的结构和功能得到最大化恢复，本文就肌腱再生中种子细胞的选取及肌腱细胞增殖所需要的最适微环境进行综述，以期为肌腱修复治疗提供新的研究思路。

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相似文献/References:

[1]余　丽,刘旭倩.类人胶原蛋白在骨组织再生修复中的应用进展[J].新乡医学院学报,2019,36(3):291.[doi:10.7683/xxyxyxb.2019.03.022]

更新日期/Last Update: 2021-02-05